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Protein

Coiled-coil domain-containing protein 154

Gene

CCDC154

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 154
Gene namesi
Name:CCDC154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:34454. CCDC154.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiCCDC154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Coiled-coil domain-containing protein 154PRO_0000332270Add
BLAST

Proteomic databases

PaxDbiA6NI56.
PRIDEiA6NI56.

Expressioni

Gene expression databases

BgeeiA6NI56.
CleanExiHS_CCDC154.
ExpressionAtlasiA6NI56. baseline and differential.

Organism-specific databases

HPAiHPA043535.
HPA048237.

Structurei

3D structure databases

ProteinModelPortaliA6NI56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili76 – 182107Sequence analysisAdd
BLAST
Coiled coili215 – 30288Sequence analysisAdd
BLAST
Coiled coili393 – 41927Sequence analysisAdd
BLAST
Coiled coili466 – 53065Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE6K. Eukaryota.
ENOG41121FM. LUCA.
GeneTreeiENSGT00390000002278.
HOGENOMiHOG000082432.
HOVERGENiHBG107604.
InParanoidiA6NI56.
OMAiNQMQALD.
OrthoDBiEOG7M3HZT.
PhylomeDBiA6NI56.
TreeFamiTF351158.

Family and domain databases

InterProiIPR029512. CCDC154.
[Graphical view]
PfamiPF15450. DUF4631. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NI56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELADSGPS GASAPSQLRA VTLEDLGLLL AGGLASPEPL SLEELSERYE
60 70 80 90 100
SSHPTSTASV PEQDTAKHWN QLEQWVVELQ AEVACLREHK QRCERATRSL
110 120 130 140 150
LRELLQVRAR VQLQGSELRQ LQQEARPAAQ APEKEAPEFS GLQNQMQALD
160 170 180 190 200
KRLVEVREAL TRLRRRQVQQ EAERRGAEQE AGLRLAKLTD LLQQEEQGRE
210 220 230 240 250
VACGALQKNQ EDSSRRVDLE VARMQAQVTK LGEEVSLRFL KREAKLCGFL
260 270 280 290 300
QKSFLALEKR MKASESSRLK LEGSLRGELE SRWEKLRGLM EERLRALQGQ
310 320 330 340 350
HEVGPGGRRA EESHLLEQCQ GLDAAVAQLT KFVQQNQASL NRVLLAEEKA
360 370 380 390 400
WDAKGRLEES RAGELAAYVQ ENLEAAQLAG ELARQEMHGE LVLLREKSRA
410 420 430 440 450
LEASVAQLAG QLKELSGHLP ALSSRLDLQE QMLGLRLSEA KTEWEGAERK
460 470 480 490 500
SLEDLARWRK EVTEHLRGVR EKVDGLPQQI ESVSDKCLLH KSDSDLRISA
510 520 530 540 550
EGKAREFKVG ALRQELATLL SSVQLLKEDN PGRKIAEMQG KLATNQIMKL
560 570 580 590 600
ENCVQANKTI QNLRFNTEAR LRTQEMATLW ESVLRLWSEE GPRTPLGSWK
610 620 630 640 650
ALPSLVRPRV FIKDMAPGKV VPMNCWGVYQ AVRWLRWKAS LIKLRALRRP
660 670
GGVLEKPHSQ EQVQQLTPSL FIQK
Length:674
Mass (Da):76,013
Last modified:July 22, 2008 - v4
Checksum:i90B3F8A43B63A16F
GO
Isoform 2 (identifier: A6NI56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-310: Missing.
     544-544: T → TFQ

Show »
Length:667
Mass (Da):75,408
Checksum:i0D022F9B7049C8FD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei302 – 3109Missing in isoform 2. 1 PublicationVSP_047467
Alternative sequencei544 – 5441T → TFQ in isoform 2. 1 PublicationVSP_047468

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN935901 mRNA. Translation: AEW67365.1.
AL031600 Genomic DNA. No translation available.
AL032819 Genomic DNA. No translation available.
AL137252 Genomic DNA. No translation available.
RefSeqiNP_001137452.1. NM_001143980.1. [A6NI56-2]
UniGeneiHs.355232.

Genome annotation databases

EnsembliENST00000389176; ENSP00000373828; ENSG00000197599. [A6NI56-1]
GeneIDi645811.
KEGGihsa:645811.
UCSCiuc059oxj.1. human. [A6NI56-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN935901 mRNA. Translation: AEW67365.1.
AL031600 Genomic DNA. No translation available.
AL032819 Genomic DNA. No translation available.
AL137252 Genomic DNA. No translation available.
RefSeqiNP_001137452.1. NM_001143980.1. [A6NI56-2]
UniGeneiHs.355232.

3D structure databases

ProteinModelPortaliA6NI56.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiCCDC154.

Proteomic databases

PaxDbiA6NI56.
PRIDEiA6NI56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389176; ENSP00000373828; ENSG00000197599. [A6NI56-1]
GeneIDi645811.
KEGGihsa:645811.
UCSCiuc059oxj.1. human. [A6NI56-1]

Organism-specific databases

CTDi645811.
GeneCardsiCCDC154.
HGNCiHGNC:34454. CCDC154.
HPAiHPA043535.
HPA048237.
neXtProtiNX_A6NI56.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6K. Eukaryota.
ENOG41121FM. LUCA.
GeneTreeiENSGT00390000002278.
HOGENOMiHOG000082432.
HOVERGENiHBG107604.
InParanoidiA6NI56.
OMAiNQMQALD.
OrthoDBiEOG7M3HZT.
PhylomeDBiA6NI56.
TreeFamiTF351158.

Miscellaneous databases

GenomeRNAii645811.
PROiA6NI56.

Gene expression databases

BgeeiA6NI56.
CleanExiHS_CCDC154.
ExpressionAtlasiA6NI56. baseline and differential.

Family and domain databases

InterProiIPR029512. CCDC154.
[Graphical view]
PfamiPF15450. DUF4631. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest."
    Liao W., Zhao R., Lu L., Zhang R., Zou J., Xu T., Wu C., Tang J., Deng Y., Lu X.
    Cell Cycle 11:3270-3279(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCC154_HUMAN
AccessioniPrimary (citable) accession number: A6NI56
Secondary accession number(s): G9JV18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 22, 2008
Last modified: June 8, 2016
This is version 58 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpression suppresses cell proliferation by inducing G2/M arrest.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.