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Protein

Coiled-coil domain-containing protein 154

Gene

CCDC154

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

Overexpression suppresses cell proliferation by inducing G2/M arrest.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 154Curated
Gene namesi
Name:CCDC154Imported
Synonyms:C16orf29Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000197599.12.
HGNCiHGNC:34454. CCDC154.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi645811.
OpenTargetsiENSG00000197599.

Polymorphism and mutation databases

BioMutaiCCDC154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322701 – 674Coiled-coil domain-containing protein 154Add BLAST674

Proteomic databases

PaxDbiA6NI56.
PRIDEiA6NI56.

PTM databases

iPTMnetiA6NI56.
PhosphoSitePlusiA6NI56.

Expressioni

Gene expression databases

BgeeiENSG00000197599.
CleanExiHS_CCDC154.
ExpressionAtlasiA6NI56. baseline and differential.

Organism-specific databases

HPAiHPA041158.
HPA043535.
HPA048237.

Interactioni

Protein-protein interaction databases

BioGridi570763. 3 interactors.
IntActiA6NI56. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA6NI56.
SMRiA6NI56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 182Sequence analysisAdd BLAST107
Coiled coili215 – 302Sequence analysisAdd BLAST88
Coiled coili393 – 419Sequence analysisAdd BLAST27
Coiled coili466 – 530Sequence analysisAdd BLAST65

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE6K. Eukaryota.
ENOG41121FM. LUCA.
GeneTreeiENSGT00390000002278.
HOGENOMiHOG000082432.
HOVERGENiHBG107604.
InParanoidiA6NI56.
OMAiTKFVQQN.
OrthoDBiEOG091G07UU.
PhylomeDBiA6NI56.
TreeFamiTF351158.

Family and domain databases

InterProiView protein in InterPro
IPR029512. CCDC154.
PANTHERiPTHR35153. PTHR35153. 1 hit.
PfamiView protein in Pfam
PF15450. CCDC154. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NI56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELADSGPS GASAPSQLRA VTLEDLGLLL AGGLASPEPL SLEELSERYE
60 70 80 90 100
SSHPTSTASV PEQDTAKHWN QLEQWVVELQ AEVACLREHK QRCERATRSL
110 120 130 140 150
LRELLQVRAR VQLQGSELRQ LQQEARPAAQ APEKEAPEFS GLQNQMQALD
160 170 180 190 200
KRLVEVREAL TRLRRRQVQQ EAERRGAEQE AGLRLAKLTD LLQQEEQGRE
210 220 230 240 250
VACGALQKNQ EDSSRRVDLE VARMQAQVTK LGEEVSLRFL KREAKLCGFL
260 270 280 290 300
QKSFLALEKR MKASESSRLK LEGSLRGELE SRWEKLRGLM EERLRALQGQ
310 320 330 340 350
HEVGPGGRRA EESHLLEQCQ GLDAAVAQLT KFVQQNQASL NRVLLAEEKA
360 370 380 390 400
WDAKGRLEES RAGELAAYVQ ENLEAAQLAG ELARQEMHGE LVLLREKSRA
410 420 430 440 450
LEASVAQLAG QLKELSGHLP ALSSRLDLQE QMLGLRLSEA KTEWEGAERK
460 470 480 490 500
SLEDLARWRK EVTEHLRGVR EKVDGLPQQI ESVSDKCLLH KSDSDLRISA
510 520 530 540 550
EGKAREFKVG ALRQELATLL SSVQLLKEDN PGRKIAEMQG KLATNQIMKL
560 570 580 590 600
ENCVQANKTI QNLRFNTEAR LRTQEMATLW ESVLRLWSEE GPRTPLGSWK
610 620 630 640 650
ALPSLVRPRV FIKDMAPGKV VPMNCWGVYQ AVRWLRWKAS LIKLRALRRP
660 670
GGVLEKPHSQ EQVQQLTPSL FIQK
Length:674
Mass (Da):76,013
Last modified:July 22, 2008 - v4
Checksum:i90B3F8A43B63A16F
GO
Isoform 2 (identifier: A6NI56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-310: Missing.
     544-544: T → TFQ

Show »
Length:667
Mass (Da):75,408
Checksum:i0D022F9B7049C8FD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047467302 – 310Missing in isoform 2. 1 Publication9
Alternative sequenceiVSP_047468544T → TFQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN935901 mRNA. Translation: AEW67365.1.
AL031600 Genomic DNA. No translation available.
AL032819 Genomic DNA. No translation available.
AL137252 Genomic DNA. No translation available.
RefSeqiNP_001137452.1. NM_001143980.1. [A6NI56-2]
UniGeneiHs.355232.

Genome annotation databases

EnsembliENST00000389176; ENSP00000373828; ENSG00000197599. [A6NI56-1]
GeneIDi645811.
KEGGihsa:645811.
UCSCiuc059oxj.1. human. [A6NI56-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCC154_HUMAN
AccessioniPrimary (citable) accession number: A6NI56
Secondary accession number(s): G9JV18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 22, 2008
Last modified: November 22, 2017
This is version 72 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM