Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6NI28 (RHG42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho GTPase-activating protein 42
Alternative name(s):
Rho GTPase-activating protein 10-like
Rho-type GTPase-activating protein 42
Gene names
Name:ARHGAP42
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length874 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a GTPase activator By similarity.

Sequence similarities

Contains 1 BAR domain.

Contains 1 PH domain.

Contains 1 Rho-GAP domain.

Contains 1 SH3 domain.

Sequence caution

The sequence BAB71456.1 differs from that shown. Reason: Probable cloning artifact.

The sequence BF511460 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

Ontologies

Keywords
   DomainCoiled coil
SH3 domain
   Molecular functionGTPase activation
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 874874Rho GTPase-activating protein 42
PRO_0000342407

Regions

Domain7 – 262256BAR
Domain265 – 374110PH
Domain376 – 572197Rho-GAP
Domain816 – 87459SH3
Coiled coil225 – 26137 Potential
Compositional bias619 – 762144Ser-rich

Amino acid modifications

Modified residue6831Phosphoserine By similarity
Modified residue7401Phosphoserine By similarity
Modified residue8111Phosphoserine Ref.4
Modified residue8701Phosphotyrosine Ref.4

Experimental info

Sequence conflict181F → V in BF511460. Ref.2
Sequence conflict1091N → D in BF511460. Ref.2
Sequence conflict1241I → M in BF511460. Ref.2
Sequence conflict5711I → V in BAB71456. Ref.3
Sequence conflict7131V → I in BAB71456. Ref.3

Sequences

Sequence LengthMass (Da)Tools
A6NI28 [UniParc].

Last modified June 15, 2010. Version 3.
Checksum: 3828623C52C52629

FASTA87498,569
        10         20         30         40         50         60 
MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL RNLSMAVQKF 

        70         80         90        100        110        120 
SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE RRRLIQNAND VLIAPLEKFR 

       130        140        150        160        170        180 
KEQIGAAKDG KKKFDKESEK YYSILEKHLN LSAKKKESHL QEADTQIDRE HQNFYEASLE 

       190        200        210        220        230        240 
YVFKIQEVQE KKKFEFVEPL LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE 

       250        260        270        280        290        300 
STRQEVERLM QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM 

       310        320        330        340        350        360 
SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG IITLQAFSEA 

       370        380        390        400        410        420 
NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK CIQAVETRGI TILGLYRIGG 

       430        440        450        460        470        480 
VNSKVQKLMN TTFSPKSPPD IDIDIELWDN KTITSGLKNY LRCLAEPLMT YKLHKDFIIA 

       490        500        510        520        530        540 
VKSDDQNYRV EAVHALVHKL PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL 

       550        560        570        580        590        600 
MRAQEETVAA MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS 

       610        620        630        640        650        660 
TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS ASCQPREKSG 

       670        680        690        700        710        720 
GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD CQSVASVTSP GDVSPPIDLV 

       730        740        750        760        770        780 
KKEPYGLSGL KRASASSLRS ISAAEGNKSY SGSIQSLTSV GSKETPKASP NPDLPPKMCR 

       790        800        810        820        830        840 
RLRLDTASSN GYQRPGSVVA AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG 

       850        860        870 
AIFSNVYPSV EPGWLKATYE GKTGLVPENY VVFL 

« Hide

References

[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-128.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 389-819.
Tissue: Testis.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811 AND TYR-870, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC015600 Genomic DNA. No translation available.
AP000872 Genomic DNA. No translation available.
AP001351 Genomic DNA. No translation available.
BF511460 mRNA. No translation available.
AK057372 mRNA. Translation: BAB71456.1. Sequence problems.
RefSeqNP_689645.2. NM_152432.2.
UniGeneHs.741465.

3D structure databases

ProteinModelPortalA6NI28.
SMRA6NI28. Positions 6-593, 819-874.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA6NI28.

Proteomic databases

MaxQBA6NI28.
PaxDbA6NI28.
PRIDEA6NI28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298815; ENSP00000298815; ENSG00000165895.
GeneID143872.
KEGGhsa:143872.
UCSCuc001pge.2. human.

Organism-specific databases

CTD143872.
GeneCardsGC11P100559.
H-InvDBHIX0026208.
HGNCHGNC:26545. ARHGAP42.
HPAHPA039924.
neXtProtNX_A6NI28.
PharmGKBPA165543186.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG311191.
HOVERGENHBG067993.
InParanoidA6NI28.
OMATPCLADP.
PhylomeDBA6NI28.
TreeFamTF316851.

Gene expression databases

ArrayExpressA6NI28.
BgeeA6NI28.
GenevestigatorA6NI28.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi143872.
NextBio84784.
PROA6NI28.

Entry information

Entry nameRHG42_HUMAN
AccessionPrimary (citable) accession number: A6NI28
Secondary accession number(s): Q96M56
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM