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A6NI28

- RHG42_HUMAN

UniProt

A6NI28 - RHG42_HUMAN

Protein

Rho GTPase-activating protein 42

Gene

ARHGAP42

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 3 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    May act as a GTPase activator.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW

    GO - Biological processi

    1. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GTPase-activating protein 42
    Alternative name(s):
    Rho GTPase-activating protein 10-like
    Rho-type GTPase-activating protein 42
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:26545. ARHGAP42.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165543186.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 874874Rho GTPase-activating protein 42PRO_0000342407Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei683 – 6831PhosphoserineBy similarity
    Modified residuei740 – 7401PhosphoserineBy similarity
    Modified residuei811 – 8111Phosphoserine1 Publication
    Modified residuei870 – 8701Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiA6NI28.
    PaxDbiA6NI28.
    PRIDEiA6NI28.

    PTM databases

    PhosphoSiteiA6NI28.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NI28.
    BgeeiA6NI28.
    GenevestigatoriA6NI28.

    Organism-specific databases

    HPAiHPA039924.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NI28.
    SMRiA6NI28. Positions 6-593, 819-874.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 262256BARAdd
    BLAST
    Domaini265 – 374110PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini376 – 572197Rho-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini816 – 87459SH3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili225 – 26137Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi619 – 762144Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAR domain.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG311191.
    HOVERGENiHBG067993.
    InParanoidiA6NI28.
    OMAiTPCLADP.
    PhylomeDBiA6NI28.
    TreeFamiTF316851.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00620. RhoGAP. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NI28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL    50
    RNLSMAVQKF SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE 100
    RRRLIQNAND VLIAPLEKFR KEQIGAAKDG KKKFDKESEK YYSILEKHLN 150
    LSAKKKESHL QEADTQIDRE HQNFYEASLE YVFKIQEVQE KKKFEFVEPL 200
    LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE STRQEVERLM 250
    QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM 300
    SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG 350
    IITLQAFSEA NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK 400
    CIQAVETRGI TILGLYRIGG VNSKVQKLMN TTFSPKSPPD IDIDIELWDN 450
    KTITSGLKNY LRCLAEPLMT YKLHKDFIIA VKSDDQNYRV EAVHALVHKL 500
    PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL MRAQEETVAA 550
    MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS 600
    TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS 650
    ASCQPREKSG GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD 700
    CQSVASVTSP GDVSPPIDLV KKEPYGLSGL KRASASSLRS ISAAEGNKSY 750
    SGSIQSLTSV GSKETPKASP NPDLPPKMCR RLRLDTASSN GYQRPGSVVA 800
    AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG AIFSNVYPSV 850
    EPGWLKATYE GKTGLVPENY VVFL 874
    Length:874
    Mass (Da):98,569
    Last modified:June 15, 2010 - v3
    Checksum:i3828623C52C52629
    GO

    Sequence cautioni

    The sequence BAB71456.1 differs from that shown. Reason: Probable cloning artifact.
    The sequence BF511460 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181F → V in BF511460. (PubMed:15489334)Curated
    Sequence conflicti109 – 1091N → D in BF511460. (PubMed:15489334)Curated
    Sequence conflicti124 – 1241I → M in BF511460. (PubMed:15489334)Curated
    Sequence conflicti571 – 5711I → V in BAB71456. (PubMed:14702039)Curated
    Sequence conflicti713 – 7131V → I in BAB71456. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC015600 Genomic DNA. No translation available.
    AP000872 Genomic DNA. No translation available.
    AP001351 Genomic DNA. No translation available.
    BF511460 mRNA. No translation available.
    AK057372 mRNA. Translation: BAB71456.1. Sequence problems.
    RefSeqiNP_689645.2. NM_152432.2.
    UniGeneiHs.741465.

    Genome annotation databases

    EnsembliENST00000298815; ENSP00000298815; ENSG00000165895.
    GeneIDi143872.
    KEGGihsa:143872.
    UCSCiuc001pge.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC015600 Genomic DNA. No translation available.
    AP000872 Genomic DNA. No translation available.
    AP001351 Genomic DNA. No translation available.
    BF511460 mRNA. No translation available.
    AK057372 mRNA. Translation: BAB71456.1 . Sequence problems.
    RefSeqi NP_689645.2. NM_152432.2.
    UniGenei Hs.741465.

    3D structure databases

    ProteinModelPortali A6NI28.
    SMRi A6NI28. Positions 6-593, 819-874.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A6NI28.

    Proteomic databases

    MaxQBi A6NI28.
    PaxDbi A6NI28.
    PRIDEi A6NI28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298815 ; ENSP00000298815 ; ENSG00000165895 .
    GeneIDi 143872.
    KEGGi hsa:143872.
    UCSCi uc001pge.2. human.

    Organism-specific databases

    CTDi 143872.
    GeneCardsi GC11P100559.
    H-InvDB HIX0026208.
    HGNCi HGNC:26545. ARHGAP42.
    HPAi HPA039924.
    neXtProti NX_A6NI28.
    PharmGKBi PA165543186.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311191.
    HOVERGENi HBG067993.
    InParanoidi A6NI28.
    OMAi TPCLADP.
    PhylomeDBi A6NI28.
    TreeFami TF316851.

    Miscellaneous databases

    GenomeRNAii 143872.
    NextBioi 84784.
    PROi A6NI28.

    Gene expression databases

    ArrayExpressi A6NI28.
    Bgeei A6NI28.
    Genevestigatori A6NI28.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00620. RhoGAP. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-128.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 389-819.
      Tissue: Testis.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811 AND TYR-870, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiRHG42_HUMAN
    AccessioniPrimary (citable) accession number: A6NI28
    Secondary accession number(s): Q96M56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 65 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3