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A6NI28

- RHG42_HUMAN

UniProt

A6NI28 - RHG42_HUMAN

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Protein

Rho GTPase-activating protein 42

Gene

ARHGAP42

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 42
Alternative name(s):
Rho GTPase-activating protein 10-like
Rho-type GTPase-activating protein 42
Gene namesi
Name:ARHGAP42
Synonyms:GRAF31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:26545. ARHGAP42.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165543186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Rho GTPase-activating protein 42PRO_0000342407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei683 – 6831PhosphoserineBy similarity
Modified residuei740 – 7401PhosphoserineBy similarity
Modified residuei811 – 8111Phosphoserine1 Publication
Modified residuei870 – 8701Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA6NI28.
PaxDbiA6NI28.
PRIDEiA6NI28.

PTM databases

PhosphoSiteiA6NI28.

Expressioni

Tissue specificityi

Highly and selectively expressed in smooth muscle cells.1 Publication

Gene expression databases

BgeeiA6NI28.
ExpressionAtlasiA6NI28. baseline and differential.
GenevestigatoriA6NI28.

Organism-specific databases

HPAiHPA039924.

Interactioni

Protein-protein interaction databases

BioGridi126819. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA6NI28.
SMRiA6NI28. Positions 6-593, 819-874.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 262256BARAdd
BLAST
Domaini265 – 374110PHPROSITE-ProRule annotationAdd
BLAST
Domaini376 – 572197Rho-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini816 – 87459SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili225 – 26137Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi619 – 762144Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 BAR domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG311191.
GeneTreeiENSGT00760000118882.
HOVERGENiHBG067993.
InParanoidiA6NI28.
OMAiTPCLADP.
PhylomeDBiA6NI28.
TreeFamiTF316851.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NI28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL
60 70 80 90 100
RNLSMAVQKF SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE
110 120 130 140 150
RRRLIQNAND VLIAPLEKFR KEQIGAAKDG KKKFDKESEK YYSILEKHLN
160 170 180 190 200
LSAKKKESHL QEADTQIDRE HQNFYEASLE YVFKIQEVQE KKKFEFVEPL
210 220 230 240 250
LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE STRQEVERLM
260 270 280 290 300
QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM
310 320 330 340 350
SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG
360 370 380 390 400
IITLQAFSEA NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK
410 420 430 440 450
CIQAVETRGI TILGLYRIGG VNSKVQKLMN TTFSPKSPPD IDIDIELWDN
460 470 480 490 500
KTITSGLKNY LRCLAEPLMT YKLHKDFIIA VKSDDQNYRV EAVHALVHKL
510 520 530 540 550
PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL MRAQEETVAA
560 570 580 590 600
MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS
610 620 630 640 650
TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS
660 670 680 690 700
ASCQPREKSG GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD
710 720 730 740 750
CQSVASVTSP GDVSPPIDLV KKEPYGLSGL KRASASSLRS ISAAEGNKSY
760 770 780 790 800
SGSIQSLTSV GSKETPKASP NPDLPPKMCR RLRLDTASSN GYQRPGSVVA
810 820 830 840 850
AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG AIFSNVYPSV
860 870
EPGWLKATYE GKTGLVPENY VVFL
Length:874
Mass (Da):98,569
Last modified:June 15, 2010 - v3
Checksum:i3828623C52C52629
GO

Sequence cautioni

The sequence BAB71456.1 differs from that shown. Reason: Probable cloning artifact.Curated
The sequence BF511460 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181F → V in BF511460. (PubMed:15489334)Curated
Sequence conflicti109 – 1091N → D in BF511460. (PubMed:15489334)Curated
Sequence conflicti124 – 1241I → M in BF511460. (PubMed:15489334)Curated
Sequence conflicti571 – 5711I → V in BAB71456. (PubMed:14702039)Curated
Sequence conflicti713 – 7131V → I in BAB71456. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015600 Genomic DNA. No translation available.
AP000872 Genomic DNA. No translation available.
AP001351 Genomic DNA. No translation available.
BF511460 mRNA. No translation available.
AK057372 mRNA. Translation: BAB71456.1. Sequence problems.
RefSeqiNP_689645.2. NM_152432.2.
UniGeneiHs.741465.

Genome annotation databases

EnsembliENST00000298815; ENSP00000298815; ENSG00000165895.
GeneIDi143872.
KEGGihsa:143872.
UCSCiuc001pge.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015600 Genomic DNA. No translation available.
AP000872 Genomic DNA. No translation available.
AP001351 Genomic DNA. No translation available.
BF511460 mRNA. No translation available.
AK057372 mRNA. Translation: BAB71456.1 . Sequence problems.
RefSeqi NP_689645.2. NM_152432.2.
UniGenei Hs.741465.

3D structure databases

ProteinModelPortali A6NI28.
SMRi A6NI28. Positions 6-593, 819-874.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126819. 1 interaction.

PTM databases

PhosphoSitei A6NI28.

Proteomic databases

MaxQBi A6NI28.
PaxDbi A6NI28.
PRIDEi A6NI28.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298815 ; ENSP00000298815 ; ENSG00000165895 .
GeneIDi 143872.
KEGGi hsa:143872.
UCSCi uc001pge.2. human.

Organism-specific databases

CTDi 143872.
GeneCardsi GC11P100559.
H-InvDB HIX0026208.
HGNCi HGNC:26545. ARHGAP42.
HPAi HPA039924.
MIMi 615936. gene.
neXtProti NX_A6NI28.
PharmGKBi PA165543186.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311191.
GeneTreei ENSGT00760000118882.
HOVERGENi HBG067993.
InParanoidi A6NI28.
OMAi TPCLADP.
PhylomeDBi A6NI28.
TreeFami TF316851.

Miscellaneous databases

ChiTaRSi ARHGAP42. human.
GenomeRNAii 143872.
NextBioi 84784.
PROi A6NI28.
SOURCEi Search...

Gene expression databases

Bgeei A6NI28.
ExpressionAtlasi A6NI28. baseline and differential.
Genevestigatori A6NI28.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-128.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 389-819.
    Tissue: Testis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811 AND TYR-870, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension."
    Bai X., Lenhart K.C., Bird K.E., Suen A.A., Rojas M., Kakoki M., Li F., Smithies O., Mack C.P., Taylor J.M.
    Nat. Commun. 4:2910-2910(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiRHG42_HUMAN
AccessioniPrimary (citable) accession number: A6NI28
Secondary accession number(s): Q96M56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3