A6NI28 (RHG42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein 42

Alternative name(s):
Rho GTPase-activating protein 10-like
Rho-type GTPase-activating protein 42

Gene names

Name:

ARHGAP42

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	874 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a GTPase activator By similarity.
Sequence similarities	Contains 1 BAR domain. Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain.
Sequence caution	The sequence BAB71456.1 differs from that shown. Reason: Probable cloning artifact. The sequence BF511460 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

Ontologies

Keywords
Domain	Coiled coil SH3 domain
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 874	874	Rho GTPase-activating protein 42		PRO_0000342407
Regions
	Domain	7 – 262	256	BAR
	Domain	265 – 374	110	PH
	Domain	376 – 572	197	Rho-GAP
	Domain	816 – 874	59	SH3
	Coiled coil	225 – 261	37	Potential
	Compositional bias	619 – 762	144	Ser-rich
Amino acid modifications
	Modified residue	811	1	Phosphoserine Ref.4
	Modified residue	870	1	Phosphotyrosine Ref.4
Experimental info
	Sequence conflict	18	1	F → V in BF511460. Ref.2
	Sequence conflict	109	1	N → D in BF511460. Ref.2
	Sequence conflict	124	1	I → M in BF511460. Ref.2
	Sequence conflict	571	1	I → V in BAB71456. Ref.3
	Sequence conflict	713	1	V → I in BAB71456. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	A6NI28 [UniParc]. Last modified June 15, 2010. Version 3. Checksum: 3828623C52C52629	FASTA	874	98,569
	10 20 30 40 50 60 MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL RNLSMAVQKF 70 80 90 100 110 120 SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE RRRLIQNAND VLIAPLEKFR 130 140 150 160 170 180 KEQIGAAKDG KKKFDKESEK YYSILEKHLN LSAKKKESHL QEADTQIDRE HQNFYEASLE 190 200 210 220 230 240 YVFKIQEVQE KKKFEFVEPL LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE 250 260 270 280 290 300 STRQEVERLM QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM 310 320 330 340 350 360 SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG IITLQAFSEA 370 380 390 400 410 420 NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK CIQAVETRGI TILGLYRIGG 430 440 450 460 470 480 VNSKVQKLMN TTFSPKSPPD IDIDIELWDN KTITSGLKNY LRCLAEPLMT YKLHKDFIIA 490 500 510 520 530 540 VKSDDQNYRV EAVHALVHKL PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL 550 560 570 580 590 600 MRAQEETVAA MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS 610 620 630 640 650 660 TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS ASCQPREKSG 670 680 690 700 710 720 GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD CQSVASVTSP GDVSPPIDLV 730 740 750 760 770 780 KKEPYGLSGL KRASASSLRS ISAAEGNKSY SGSIQSLTSV GSKETPKASP NPDLPPKMCR 790 800 810 820 830 840 RLRLDTASSN GYQRPGSVVA AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG 850 860 870 AIFSNVYPSV EPGWLKATYE GKTGLVPENY VVFL

References

[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-128.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 389-819. Tissue: Testis.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811 AND TYR-870, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC015600 Genomic DNA. No translation available. AP000872 Genomic DNA. No translation available. AP001351 Genomic DNA. No translation available. BF511460 mRNA. No translation available. AK057372 mRNA. Translation: BAB71456.1. Sequence problems.
IPI	IPI00902744.
RefSeq	NP_689645.2. NM_152432.2.
UniGene	Hs.741465.
3D structure databases
HSSP	HSSP built from PDB template 1RGP based on UniProtKB Q07960.
ProteinModelPortal	A6NI28.
SMR	A6NI28. Positions 6-370, 390-577, 819-874.
ModBase	Search...
PTM databases
PhosphoSite	A6NI28.
Proteomic databases
PaxDb	A6NI28.
PRIDE	A6NI28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298815; ENSP00000298815; ENSG00000165895.
GeneID	143872.
KEGG	hsa:143872.
UCSC	uc001pge.2. human.
Organism-specific databases
CTD	143872.
GeneCards	GC11P100559.
H-InvDB	HIX0026208.
HGNC	HGNC:26545. ARHGAP42.
HPA	HPA039924.
neXtProt	NX_A6NI28.
PharmGKB	PA165543186.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG311191.
HOVERGEN	HBG067993.
InParanoid	A6NI28.
OMA	YVQEKPL.
OrthoDB	EOG4VMFF4.
Gene expression databases
ArrayExpress	A6NI28.
Bgee	A6NI28.
Genevestigator	A6NI28.
Family and domain databases
Gene3D	1.10.555.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00620. RhoGAP. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00324. RhoGAP. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS51021. BAR. False negative. PS50003. PH_DOMAIN. 1 hit. PS50238. RHOGAP. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	143872.
NextBio	84784.

Entry information

Entry name

RHG42_HUMAN

Accession

Primary (citable) accession number: A6NI28
Secondary accession number(s): Q96M56

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 53 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.