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Protein

Rho GTPase-activating protein 42

Gene

ARHGAP42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 42
Alternative name(s):
Rho GTPase-activating protein 10-like
Rho-type GTPase-activating protein 42
Gene namesi
Name:ARHGAP42
Synonyms:GRAF31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000165895.17
HGNCiHGNC:26545 ARHGAP42
MIMi615936 gene
neXtProtiNX_A6NI28

Pathology & Biotechi

Organism-specific databases

DisGeNETi143872
OpenTargetsiENSG00000165895
PharmGKBiPA165543186

Polymorphism and mutation databases

BioMutaiARHGAP42

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003424071 – 874Rho GTPase-activating protein 42Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei376PhosphotyrosineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei811PhosphoserineCombined sources1
Modified residuei870PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA6NI28
PaxDbiA6NI28
PRIDEiA6NI28

PTM databases

iPTMnetiA6NI28
PhosphoSitePlusiA6NI28

Expressioni

Tissue specificityi

Highly and selectively expressed in smooth muscle cells.1 Publication

Gene expression databases

BgeeiENSG00000165895
ExpressionAtlasiA6NI28 baseline and differential
GenevisibleiA6NI28 HS

Organism-specific databases

HPAiHPA039924

Interactioni

Protein-protein interaction databases

BioGridi126819, 6 interactors
STRINGi9606.ENSP00000298815

Structurei

3D structure databases

ProteinModelPortaliA6NI28
SMRiA6NI28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 262BARAdd BLAST256
Domaini265 – 374PHPROSITE-ProRule annotationAdd BLAST110
Domaini376 – 572Rho-GAPPROSITE-ProRule annotationAdd BLAST197
Domaini816 – 874SH3PROSITE-ProRule annotationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 261Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi619 – 762Ser-richAdd BLAST144

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG1451 Eukaryota
ENOG410YJPS LUCA
GeneTreeiENSGT00890000139322
HOVERGENiHBG067993
InParanoidiA6NI28
KOiK20651
OMAiFLYLNEA
OrthoDBiEOG091G01TT
PhylomeDBiA6NI28
TreeFamiTF316851

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

A6NI28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL
60 70 80 90 100
RNLSMAVQKF SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE
110 120 130 140 150
RRRLIQNAND VLIAPLEKFR KEQIGAAKDG KKKFDKESEK YYSILEKHLN
160 170 180 190 200
LSAKKKESHL QEADTQIDRE HQNFYEASLE YVFKIQEVQE KKKFEFVEPL
210 220 230 240 250
LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE STRQEVERLM
260 270 280 290 300
QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM
310 320 330 340 350
SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG
360 370 380 390 400
IITLQAFSEA NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK
410 420 430 440 450
CIQAVETRGI TILGLYRIGG VNSKVQKLMN TTFSPKSPPD IDIDIELWDN
460 470 480 490 500
KTITSGLKNY LRCLAEPLMT YKLHKDFIIA VKSDDQNYRV EAVHALVHKL
510 520 530 540 550
PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL MRAQEETVAA
560 570 580 590 600
MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS
610 620 630 640 650
TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS
660 670 680 690 700
ASCQPREKSG GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD
710 720 730 740 750
CQSVASVTSP GDVSPPIDLV KKEPYGLSGL KRASASSLRS ISAAEGNKSY
760 770 780 790 800
SGSIQSLTSV GSKETPKASP NPDLPPKMCR RLRLDTASSN GYQRPGSVVA
810 820 830 840 850
AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG AIFSNVYPSV
860 870
EPGWLKATYE GKTGLVPENY VVFL
Length:874
Mass (Da):98,569
Last modified:June 15, 2010 - v3
Checksum:i3828623C52C52629
GO

Sequence cautioni

The sequence BAB71456 differs from that shown. Probable cloning artifact.Curated
The sequence BF511460 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18F → V in BF511460 (PubMed:15489334).Curated1
Sequence conflicti109N → D in BF511460 (PubMed:15489334).Curated1
Sequence conflicti124I → M in BF511460 (PubMed:15489334).Curated1
Sequence conflicti571I → V in BAB71456 (PubMed:14702039).Curated1
Sequence conflicti713V → I in BAB71456 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015600 Genomic DNA No translation available.
AP000872 Genomic DNA No translation available.
AP001351 Genomic DNA No translation available.
BF511460 mRNA No translation available.
AK057372 mRNA Translation: BAB71456.1 Sequence problems.
RefSeqiNP_689645.2, NM_152432.2
UniGeneiHs.44004
Hs.741465

Genome annotation databases

EnsembliENST00000298815; ENSP00000298815; ENSG00000165895
GeneIDi143872
KEGGihsa:143872
UCSCiuc001pge.2 human

Similar proteinsi

Entry informationi

Entry nameiRHG42_HUMAN
AccessioniPrimary (citable) accession number: A6NI28
Secondary accession number(s): Q96M56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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