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Protein

Rho GTPase-activating protein 42

Gene

ARHGAP42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:G66-30727-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 42
Alternative name(s):
Rho GTPase-activating protein 10-like
Rho-type GTPase-activating protein 42
Gene namesi
Name:ARHGAP42
Synonyms:GRAF31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26545. ARHGAP42.

Pathology & Biotechi

Organism-specific databases

DisGeNETi143872.
OpenTargetsiENSG00000165895.
PharmGKBiPA165543186.

Polymorphism and mutation databases

BioMutaiARHGAP42.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003424071 – 874Rho GTPase-activating protein 42Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei376PhosphotyrosineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei811PhosphoserineCombined sources1
Modified residuei870PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA6NI28.
PaxDbiA6NI28.
PRIDEiA6NI28.

PTM databases

iPTMnetiA6NI28.
PhosphoSitePlusiA6NI28.

Expressioni

Tissue specificityi

Highly and selectively expressed in smooth muscle cells.1 Publication

Gene expression databases

BgeeiENSG00000165895.
ExpressionAtlasiA6NI28. baseline and differential.
GenevisibleiA6NI28. HS.

Organism-specific databases

HPAiHPA039924.

Interactioni

Protein-protein interaction databases

BioGridi126819. 6 interactors.
STRINGi9606.ENSP00000298815.

Structurei

3D structure databases

ProteinModelPortaliA6NI28.
SMRiA6NI28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 262BARAdd BLAST256
Domaini265 – 374PHPROSITE-ProRule annotationAdd BLAST110
Domaini376 – 572Rho-GAPPROSITE-ProRule annotationAdd BLAST197
Domaini816 – 874SH3PROSITE-ProRule annotationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 261Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi619 – 762Ser-richAdd BLAST144

Sequence similaritiesi

Contains 1 BAR domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG1451. Eukaryota.
ENOG410YJPS. LUCA.
GeneTreeiENSGT00840000129684.
HOVERGENiHBG067993.
InParanoidiA6NI28.
KOiK20651.
OMAiMFLNEAG.
OrthoDBiEOG091G01TT.
PhylomeDBiA6NI28.
TreeFamiTF316851.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NI28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL
60 70 80 90 100
RNLSMAVQKF SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE
110 120 130 140 150
RRRLIQNAND VLIAPLEKFR KEQIGAAKDG KKKFDKESEK YYSILEKHLN
160 170 180 190 200
LSAKKKESHL QEADTQIDRE HQNFYEASLE YVFKIQEVQE KKKFEFVEPL
210 220 230 240 250
LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE STRQEVERLM
260 270 280 290 300
QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM
310 320 330 340 350
SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG
360 370 380 390 400
IITLQAFSEA NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK
410 420 430 440 450
CIQAVETRGI TILGLYRIGG VNSKVQKLMN TTFSPKSPPD IDIDIELWDN
460 470 480 490 500
KTITSGLKNY LRCLAEPLMT YKLHKDFIIA VKSDDQNYRV EAVHALVHKL
510 520 530 540 550
PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL MRAQEETVAA
560 570 580 590 600
MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS
610 620 630 640 650
TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS
660 670 680 690 700
ASCQPREKSG GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD
710 720 730 740 750
CQSVASVTSP GDVSPPIDLV KKEPYGLSGL KRASASSLRS ISAAEGNKSY
760 770 780 790 800
SGSIQSLTSV GSKETPKASP NPDLPPKMCR RLRLDTASSN GYQRPGSVVA
810 820 830 840 850
AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG AIFSNVYPSV
860 870
EPGWLKATYE GKTGLVPENY VVFL
Length:874
Mass (Da):98,569
Last modified:June 15, 2010 - v3
Checksum:i3828623C52C52629
GO

Sequence cautioni

The sequence BAB71456 differs from that shown. Probable cloning artifact.Curated
The sequence BF511460 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18F → V in BF511460 (PubMed:15489334).Curated1
Sequence conflicti109N → D in BF511460 (PubMed:15489334).Curated1
Sequence conflicti124I → M in BF511460 (PubMed:15489334).Curated1
Sequence conflicti571I → V in BAB71456 (PubMed:14702039).Curated1
Sequence conflicti713V → I in BAB71456 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015600 Genomic DNA. No translation available.
AP000872 Genomic DNA. No translation available.
AP001351 Genomic DNA. No translation available.
BF511460 mRNA. No translation available.
AK057372 mRNA. Translation: BAB71456.1. Sequence problems.
RefSeqiNP_689645.2. NM_152432.2.
UniGeneiHs.741465.

Genome annotation databases

EnsembliENST00000298815; ENSP00000298815; ENSG00000165895.
GeneIDi143872.
KEGGihsa:143872.
UCSCiuc001pge.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015600 Genomic DNA. No translation available.
AP000872 Genomic DNA. No translation available.
AP001351 Genomic DNA. No translation available.
BF511460 mRNA. No translation available.
AK057372 mRNA. Translation: BAB71456.1. Sequence problems.
RefSeqiNP_689645.2. NM_152432.2.
UniGeneiHs.741465.

3D structure databases

ProteinModelPortaliA6NI28.
SMRiA6NI28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126819. 6 interactors.
STRINGi9606.ENSP00000298815.

PTM databases

iPTMnetiA6NI28.
PhosphoSitePlusiA6NI28.

Polymorphism and mutation databases

BioMutaiARHGAP42.

Proteomic databases

MaxQBiA6NI28.
PaxDbiA6NI28.
PRIDEiA6NI28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298815; ENSP00000298815; ENSG00000165895.
GeneIDi143872.
KEGGihsa:143872.
UCSCiuc001pge.2. human.

Organism-specific databases

CTDi143872.
DisGeNETi143872.
GeneCardsiARHGAP42.
H-InvDBHIX0026208.
HGNCiHGNC:26545. ARHGAP42.
HPAiHPA039924.
MIMi615936. gene.
neXtProtiNX_A6NI28.
OpenTargetsiENSG00000165895.
PharmGKBiPA165543186.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1451. Eukaryota.
ENOG410YJPS. LUCA.
GeneTreeiENSGT00840000129684.
HOVERGENiHBG067993.
InParanoidiA6NI28.
KOiK20651.
OMAiMFLNEAG.
OrthoDBiEOG091G01TT.
PhylomeDBiA6NI28.
TreeFamiTF316851.

Enzyme and pathway databases

BioCyciZFISH:G66-30727-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARHGAP42. human.
GenomeRNAii143872.
PROiA6NI28.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165895.
ExpressionAtlasiA6NI28. baseline and differential.
GenevisibleiA6NI28. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG42_HUMAN
AccessioniPrimary (citable) accession number: A6NI28
Secondary accession number(s): Q96M56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 15, 2010
Last modified: November 30, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.