ID   MSGN1_HUMAN             Reviewed;         193 AA.
AC   A6NI15;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 126.
DE   RecName: Full=Mesogenin-1;
DE   AltName: Full=Paraxial mesoderm-specific mesogenin1;
DE   AltName: Full=pMesogenin1;
DE            Short=pMsgn1;
GN   Name=MSGN1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- FUNCTION: Involved in specifying the paraxial, but not dorsal,
CC       mesoderm. May regulate the expression of T-box transcription factors
CC       required for mesoderm formation and differentiation (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       A6NI15; Q10567-3: AP1B1; NbExp=3; IntAct=EBI-11991020, EBI-11978055;
CC       A6NI15; A0A0C4DG94: ATP11B; NbExp=3; IntAct=EBI-11991020, EBI-11990784;
CC       A6NI15; Q6PJG6: BRAT1; NbExp=3; IntAct=EBI-11991020, EBI-10826195;
CC       A6NI15; P0C7W6: CCDC172; NbExp=3; IntAct=EBI-11991020, EBI-2548868;
CC       A6NI15; P78358: CTAG1B; NbExp=3; IntAct=EBI-11991020, EBI-1188472;
CC       A6NI15; O14645: DNALI1; NbExp=3; IntAct=EBI-11991020, EBI-395638;
CC       A6NI15; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-11991020, EBI-6251402;
CC       A6NI15; P54257: HAP1; NbExp=3; IntAct=EBI-11991020, EBI-712814;
CC       A6NI15; P41134: ID1; NbExp=5; IntAct=EBI-11991020, EBI-1215527;
CC       A6NI15; Q02363: ID2; NbExp=3; IntAct=EBI-11991020, EBI-713450;
CC       A6NI15; Q02535: ID3; NbExp=3; IntAct=EBI-11991020, EBI-1387094;
CC       A6NI15; P24592: IGFBP6; NbExp=3; IntAct=EBI-11991020, EBI-947015;
CC       A6NI15; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-11991020, EBI-712105;
CC       A6NI15; O95751: LDOC1; NbExp=3; IntAct=EBI-11991020, EBI-740738;
CC       A6NI15; P43360: MAGEA6; NbExp=3; IntAct=EBI-11991020, EBI-1045155;
CC       A6NI15; P13349: MYF5; NbExp=3; IntAct=EBI-11991020, EBI-17491620;
CC       A6NI15; P24844-2: MYL9; NbExp=3; IntAct=EBI-11991020, EBI-13066228;
CC       A6NI15; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-11991020, EBI-10172876;
CC       A6NI15; P0C6T2: OST4; NbExp=3; IntAct=EBI-11991020, EBI-18397963;
CC       A6NI15; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-11991020, EBI-748621;
CC       A6NI15; Q99081-3: TCF12; NbExp=3; IntAct=EBI-11991020, EBI-11952764;
CC       A6NI15; P15884-3: TCF4; NbExp=3; IntAct=EBI-11991020, EBI-13636688;
CC       A6NI15; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-11991020, EBI-11139477;
CC       A6NI15; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-11991020, EBI-12090309;
CC       A6NI15; Q13077: TRAF1; NbExp=3; IntAct=EBI-11991020, EBI-359224;
CC       A6NI15; Q6PF05: TTC23L; NbExp=5; IntAct=EBI-11991020, EBI-8656864;
CC       A6NI15; Q9H0C1: ZMYND12; NbExp=5; IntAct=EBI-11991020, EBI-12030590;
CC       A6NI15; O95229: ZWINT; NbExp=3; IntAct=EBI-11991020, EBI-1001132;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; AC093731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS42657.1; -.
DR   RefSeq; NP_001099039.1; NM_001105569.1.
DR   AlphaFoldDB; A6NI15; -.
DR   SMR; A6NI15; -.
DR   BioGRID; 131280; 40.
DR   IntAct; A6NI15; 28.
DR   STRING; 9606.ENSP00000281047; -.
DR   PhosphoSitePlus; A6NI15; -.
DR   BioMuta; MSGN1; -.
DR   MassIVE; A6NI15; -.
DR   PaxDb; 9606-ENSP00000281047; -.
DR   Antibodypedia; 64308; 84 antibodies from 13 providers.
DR   DNASU; 343930; -.
DR   Ensembl; ENST00000281047.4; ENSP00000281047.3; ENSG00000151379.4.
DR   GeneID; 343930; -.
DR   KEGG; hsa:343930; -.
DR   MANE-Select; ENST00000281047.4; ENSP00000281047.3; NM_001105569.3; NP_001099039.1.
DR   UCSC; uc010yjt.3; human.
DR   AGR; HGNC:14907; -.
DR   CTD; 343930; -.
DR   DisGeNET; 343930; -.
DR   GeneCards; MSGN1; -.
DR   HGNC; HGNC:14907; MSGN1.
DR   HPA; ENSG00000151379; Tissue enriched (choroid).
DR   MIM; 612209; gene.
DR   neXtProt; NX_A6NI15; -.
DR   OpenTargets; ENSG00000151379; -.
DR   PharmGKB; PA142671315; -.
DR   VEuPathDB; HostDB:ENSG00000151379; -.
DR   eggNOG; KOG4029; Eukaryota.
DR   GeneTree; ENSGT00530000063712; -.
DR   HOGENOM; CLU_084234_1_0_1; -.
DR   InParanoid; A6NI15; -.
DR   OMA; SSWDWKN; -.
DR   OrthoDB; 5354298at2759; -.
DR   PhylomeDB; A6NI15; -.
DR   TreeFam; TF325707; -.
DR   PathwayCommons; A6NI15; -.
DR   Reactome; R-HSA-9793380; Formation of paraxial mesoderm.
DR   Reactome; R-HSA-9824272; Somitogenesis.
DR   SignaLink; A6NI15; -.
DR   BioGRID-ORCS; 343930; 3 hits in 1159 CRISPR screens.
DR   GenomeRNAi; 343930; -.
DR   Pharos; A6NI15; Tbio.
DR   PRO; PR:A6NI15; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A6NI15; Protein.
DR   Bgee; ENSG00000151379; Expressed in bone marrow cell and 9 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007379; P:segment specification; IEA:Ensembl.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   CDD; cd18939; bHLH_TS_Msgn1; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR040259; Mesogenin/MesP.
DR   PANTHER; PTHR20937; IP14615P; 1.
DR   PANTHER; PTHR20937:SF4; MESOGENIN-1; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..193
FT                   /note="Mesogenin-1"
FT                   /id="PRO_0000330028"
FT   DOMAIN          124..178
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          34..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         80
FT                   /note="E -> D (in dbSNP:rs34069439)"
FT                   /id="VAR_061259"
FT   VARIANT         104
FT                   /note="H -> Y (in dbSNP:rs35858730)"
FT                   /id="VAR_061260"
SQ   SEQUENCE   193 AA;  20778 MW;  B57034F9C39C84B1 CRC64;
     MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA PSLESYSSSP
     CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF QPTHLQGGGG PKAQKGTKVR
     MSVQRRRKAS EREKLRMRTL ADALHTLRNY LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD
     LLNRGREPRA QSA
//