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Protein

Mesogenin-1

Gene

MSGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mesogenin-1
Alternative name(s):
Paraxial mesoderm-specific mesogenin1
pMesogenin1
Short name:
pMsgn1
Gene namesi
Name:MSGN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14907. MSGN1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671315.

Polymorphism and mutation databases

BioMutaiMSGN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Mesogenin-1PRO_0000330028Add
BLAST

Proteomic databases

PaxDbiA6NI15.
PRIDEiA6NI15.

PTM databases

PhosphoSiteiA6NI15.

Expressioni

Gene expression databases

BgeeiA6NI15.
CleanExiHS_MSGN1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281047.

Structurei

3D structure databases

ProteinModelPortaliA6NI15.
SMRiA6NI15. Positions 123-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 17855bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG254790.
GeneTreeiENSGT00530000063712.
HOGENOMiHOG000070445.
HOVERGENiHBG105692.
InParanoidiA6NI15.
KOiK09077.
OMAiSSWDWKN.
OrthoDBiEOG7P5T36.
PhylomeDBiA6NI15.
TreeFamiTF325707.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NI15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA
60 70 80 90 100
PSLESYSSSP CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF
110 120 130 140 150
QPTHLQGGGG PKAQKGTKVR MSVQRRRKAS EREKLRMRTL ADALHTLRNY
160 170 180 190
LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD LLNRGREPRA QSA
Length:193
Mass (Da):20,778
Last modified:July 24, 2007 - v1
Checksum:iB57034F9C39C84B1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801E → D.
Corresponds to variant rs34069439 [ dbSNP | Ensembl ].
VAR_061259
Natural varianti104 – 1041H → Y.
Corresponds to variant rs35858730 [ dbSNP | Ensembl ].
VAR_061260

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093731 Genomic DNA. No translation available.
CCDSiCCDS42657.1.
RefSeqiNP_001099039.1. NM_001105569.1.
UniGeneiHs.705359.

Genome annotation databases

EnsembliENST00000281047; ENSP00000281047; ENSG00000151379.
GeneIDi343930.
KEGGihsa:343930.
UCSCiuc010yjt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093731 Genomic DNA. No translation available.
CCDSiCCDS42657.1.
RefSeqiNP_001099039.1. NM_001105569.1.
UniGeneiHs.705359.

3D structure databases

ProteinModelPortaliA6NI15.
SMRiA6NI15. Positions 123-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281047.

PTM databases

PhosphoSiteiA6NI15.

Polymorphism and mutation databases

BioMutaiMSGN1.

Proteomic databases

PaxDbiA6NI15.
PRIDEiA6NI15.

Protocols and materials databases

DNASUi343930.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281047; ENSP00000281047; ENSG00000151379.
GeneIDi343930.
KEGGihsa:343930.
UCSCiuc010yjt.2. human.

Organism-specific databases

CTDi343930.
GeneCardsiGC02P017997.
HGNCiHGNC:14907. MSGN1.
MIMi612209. gene.
neXtProtiNX_A6NI15.
PharmGKBiPA142671315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG254790.
GeneTreeiENSGT00530000063712.
HOGENOMiHOG000070445.
HOVERGENiHBG105692.
InParanoidiA6NI15.
KOiK09077.
OMAiSSWDWKN.
OrthoDBiEOG7P5T36.
PhylomeDBiA6NI15.
TreeFamiTF325707.

Miscellaneous databases

GenomeRNAii343930.
NextBioi98611.
PROiA6NI15.
SOURCEiSearch...

Gene expression databases

BgeeiA6NI15.
CleanExiHS_MSGN1.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMSGN1_HUMAN
AccessioniPrimary (citable) accession number: A6NI15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.