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A6NI15

- MSGN1_HUMAN

UniProt

A6NI15 - MSGN1_HUMAN

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Protein

Mesogenin-1

Gene
MSGN1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. segment specification Source: Ensembl
  4. somitogenesis Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mesogenin-1
Alternative name(s):
Paraxial mesoderm-specific mesogenin1
pMesogenin1
Short name:
pMsgn1
Gene namesi
Name:MSGN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:14907. MSGN1.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Mesogenin-1PRO_0000330028Add
BLAST

Proteomic databases

PaxDbiA6NI15.
PRIDEiA6NI15.

PTM databases

PhosphoSiteiA6NI15.

Expressioni

Gene expression databases

BgeeiA6NI15.
CleanExiHS_MSGN1.
GenevestigatoriA6NI15.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281047.

Structurei

3D structure databases

ProteinModelPortaliA6NI15.
SMRiA6NI15. Positions 123-180.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 17855bHLHAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG254790.
HOGENOMiHOG000070445.
HOVERGENiHBG105692.
InParanoidiA6NI15.
KOiK09077.
OMAiSWDWKDR.
OrthoDBiEOG7P5T36.
PhylomeDBiA6NI15.
TreeFamiTF325707.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NI15-1 [UniParc]FASTAAdd to Basket

« Hide

MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA    50
PSLESYSSSP CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF 100
QPTHLQGGGG PKAQKGTKVR MSVQRRRKAS EREKLRMRTL ADALHTLRNY 150
LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD LLNRGREPRA QSA 193
Length:193
Mass (Da):20,778
Last modified:July 24, 2007 - v1
Checksum:iB57034F9C39C84B1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801E → D.
Corresponds to variant rs34069439 [ dbSNP | Ensembl ].
VAR_061259
Natural varianti104 – 1041H → Y.
Corresponds to variant rs35858730 [ dbSNP | Ensembl ].
VAR_061260

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093731 Genomic DNA. No translation available.
CCDSiCCDS42657.1.
RefSeqiNP_001099039.1. NM_001105569.1.
UniGeneiHs.705359.

Genome annotation databases

EnsembliENST00000281047; ENSP00000281047; ENSG00000151379.
GeneIDi343930.
KEGGihsa:343930.
UCSCiuc010yjt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093731 Genomic DNA. No translation available.
CCDSi CCDS42657.1.
RefSeqi NP_001099039.1. NM_001105569.1.
UniGenei Hs.705359.

3D structure databases

ProteinModelPortali A6NI15.
SMRi A6NI15. Positions 123-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000281047.

PTM databases

PhosphoSitei A6NI15.

Proteomic databases

PaxDbi A6NI15.
PRIDEi A6NI15.

Protocols and materials databases

DNASUi 343930.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281047 ; ENSP00000281047 ; ENSG00000151379 .
GeneIDi 343930.
KEGGi hsa:343930.
UCSCi uc010yjt.2. human.

Organism-specific databases

CTDi 343930.
GeneCardsi GC02P017997.
HGNCi HGNC:14907. MSGN1.
MIMi 612209. gene.
neXtProti NX_A6NI15.
PharmGKBi PA142671315.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254790.
HOGENOMi HOG000070445.
HOVERGENi HBG105692.
InParanoidi A6NI15.
KOi K09077.
OMAi SWDWKDR.
OrthoDBi EOG7P5T36.
PhylomeDBi A6NI15.
TreeFami TF325707.

Miscellaneous databases

GenomeRNAii 343930.
NextBioi 98611.
PROi A6NI15.
SOURCEi Search...

Gene expression databases

Bgeei A6NI15.
CleanExi HS_MSGN1.
Genevestigatori A6NI15.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMSGN1_HUMAN
AccessioniPrimary (citable) accession number: A6NI15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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