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Protein

Mesogenin-1

Gene

MSGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mesogenin-1
Alternative name(s):
Paraxial mesoderm-specific mesogenin1
pMesogenin1
Short name:
pMsgn1
Gene namesi
Name:MSGN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000151379.3.
HGNCiHGNC:14907. MSGN1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi343930.
OpenTargetsiENSG00000151379.
PharmGKBiPA142671315.

Polymorphism and mutation databases

BioMutaiMSGN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300281 – 193Mesogenin-1Add BLAST193

Proteomic databases

PaxDbiA6NI15.
PRIDEiA6NI15.

PTM databases

PhosphoSitePlusiA6NI15.

Expressioni

Gene expression databases

BgeeiENSG00000151379.
CleanExiHS_MSGN1.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA6NI15. 20 interactors.
STRINGi9606.ENSP00000281047.

Structurei

3D structure databases

ProteinModelPortaliA6NI15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 178bHLHPROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00530000063712.
HOGENOMiHOG000070445.
HOVERGENiHBG105692.
InParanoidiA6NI15.
KOiK09077.
OMAiSSWDWKN.
OrthoDBiEOG091G0N6N.
PhylomeDBiA6NI15.
TreeFamiTF325707.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NI15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA
60 70 80 90 100
PSLESYSSSP CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF
110 120 130 140 150
QPTHLQGGGG PKAQKGTKVR MSVQRRRKAS EREKLRMRTL ADALHTLRNY
160 170 180 190
LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD LLNRGREPRA QSA
Length:193
Mass (Da):20,778
Last modified:July 24, 2007 - v1
Checksum:iB57034F9C39C84B1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06125980E → D. Corresponds to variant dbSNP:rs34069439Ensembl.1
Natural variantiVAR_061260104H → Y. Corresponds to variant dbSNP:rs35858730Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093731 Genomic DNA. No translation available.
CCDSiCCDS42657.1.
RefSeqiNP_001099039.1. NM_001105569.1.

Genome annotation databases

EnsembliENST00000281047; ENSP00000281047; ENSG00000151379.
GeneIDi343930.
KEGGihsa:343930.
UCSCiuc010yjt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMSGN1_HUMAN
AccessioniPrimary (citable) accession number: A6NI15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: November 22, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot