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A6NI15

- MSGN1_HUMAN

UniProt

A6NI15 - MSGN1_HUMAN

Protein

Mesogenin-1

Gene

MSGN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. segment specification Source: Ensembl
    4. somitogenesis Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mesogenin-1
    Alternative name(s):
    Paraxial mesoderm-specific mesogenin1
    pMesogenin1
    Short name:
    pMsgn1
    Gene namesi
    Name:MSGN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:14907. MSGN1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671315.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Mesogenin-1PRO_0000330028Add
    BLAST

    Proteomic databases

    PaxDbiA6NI15.
    PRIDEiA6NI15.

    PTM databases

    PhosphoSiteiA6NI15.

    Expressioni

    Gene expression databases

    BgeeiA6NI15.
    CleanExiHS_MSGN1.
    GenevestigatoriA6NI15.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000281047.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NI15.
    SMRiA6NI15. Positions 123-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 17855bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG254790.
    HOGENOMiHOG000070445.
    HOVERGENiHBG105692.
    InParanoidiA6NI15.
    KOiK09077.
    OMAiSWDWKDR.
    OrthoDBiEOG7P5T36.
    PhylomeDBiA6NI15.
    TreeFamiTF325707.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NI15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA    50
    PSLESYSSSP CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF 100
    QPTHLQGGGG PKAQKGTKVR MSVQRRRKAS EREKLRMRTL ADALHTLRNY 150
    LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD LLNRGREPRA QSA 193
    Length:193
    Mass (Da):20,778
    Last modified:July 24, 2007 - v1
    Checksum:iB57034F9C39C84B1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 801E → D.
    Corresponds to variant rs34069439 [ dbSNP | Ensembl ].
    VAR_061259
    Natural varianti104 – 1041H → Y.
    Corresponds to variant rs35858730 [ dbSNP | Ensembl ].
    VAR_061260

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093731 Genomic DNA. No translation available.
    CCDSiCCDS42657.1.
    RefSeqiNP_001099039.1. NM_001105569.1.
    UniGeneiHs.705359.

    Genome annotation databases

    EnsembliENST00000281047; ENSP00000281047; ENSG00000151379.
    GeneIDi343930.
    KEGGihsa:343930.
    UCSCiuc010yjt.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093731 Genomic DNA. No translation available.
    CCDSi CCDS42657.1.
    RefSeqi NP_001099039.1. NM_001105569.1.
    UniGenei Hs.705359.

    3D structure databases

    ProteinModelPortali A6NI15.
    SMRi A6NI15. Positions 123-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000281047.

    PTM databases

    PhosphoSitei A6NI15.

    Proteomic databases

    PaxDbi A6NI15.
    PRIDEi A6NI15.

    Protocols and materials databases

    DNASUi 343930.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281047 ; ENSP00000281047 ; ENSG00000151379 .
    GeneIDi 343930.
    KEGGi hsa:343930.
    UCSCi uc010yjt.2. human.

    Organism-specific databases

    CTDi 343930.
    GeneCardsi GC02P017997.
    HGNCi HGNC:14907. MSGN1.
    MIMi 612209. gene.
    neXtProti NX_A6NI15.
    PharmGKBi PA142671315.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254790.
    HOGENOMi HOG000070445.
    HOVERGENi HBG105692.
    InParanoidi A6NI15.
    KOi K09077.
    OMAi SWDWKDR.
    OrthoDBi EOG7P5T36.
    PhylomeDBi A6NI15.
    TreeFami TF325707.

    Miscellaneous databases

    GenomeRNAii 343930.
    NextBioi 98611.
    PROi A6NI15.
    SOURCEi Search...

    Gene expression databases

    Bgeei A6NI15.
    CleanExi HS_MSGN1.
    Genevestigatori A6NI15.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMSGN1_HUMAN
    AccessioniPrimary (citable) accession number: A6NI15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3