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A6NI15 (MSGN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mesogenin-1
Alternative name(s):
Paraxial mesoderm-specific mesogenin1
pMesogenin1
Short name=pMsgn1
Gene names
Name:MSGN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation By similarity.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

segment specification

Inferred from electronic annotation. Source: Ensembl

somitogenesis

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Mesogenin-1
PRO_0000330028

Regions

Domain124 – 17855bHLH

Natural variations

Natural variant801E → D.
Corresponds to variant rs34069439 [ dbSNP | Ensembl ].
VAR_061259
Natural variant1041H → Y.
Corresponds to variant rs35858730 [ dbSNP | Ensembl ].
VAR_061260

Sequences

Sequence LengthMass (Da)Tools
A6NI15 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: B57034F9C39C84B1

FASTA19320,778
        10         20         30         40         50         60 
MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA PSLESYSSSP 

        70         80         90        100        110        120 
CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF QPTHLQGGGG PKAQKGTKVR 

       130        140        150        160        170        180 
MSVQRRRKAS EREKLRMRTL ADALHTLRNY LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD 

       190 
LLNRGREPRA QSA 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC093731 Genomic DNA. No translation available.
RefSeqNP_001099039.1. NM_001105569.1.
UniGeneHs.705359.

3D structure databases

ProteinModelPortalA6NI15.
SMRA6NI15. Positions 125-183.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000281047.

PTM databases

PhosphoSiteA6NI15.

Proteomic databases

PaxDbA6NI15.
PRIDEA6NI15.

Protocols and materials databases

DNASU343930.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281047; ENSP00000281047; ENSG00000151379.
GeneID343930.
KEGGhsa:343930.
UCSCuc010yjt.2. human.

Organism-specific databases

CTD343930.
GeneCardsGC02P017997.
HGNCHGNC:14907. MSGN1.
MIM612209. gene.
neXtProtNX_A6NI15.
PharmGKBPA142671315.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254790.
HOGENOMHOG000070445.
HOVERGENHBG105692.
InParanoidA6NI15.
KOK09077.
OMAFELNQAS.
OrthoDBEOG7P5T36.
PhylomeDBA6NI15.
TreeFamTF325707.

Gene expression databases

BgeeA6NI15.
CleanExHS_MSGN1.
GenevestigatorA6NI15.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi343930.
NextBio98611.
PROA6NI15.
SOURCESearch...

Entry information

Entry nameMSGN1_HUMAN
AccessionPrimary (citable) accession number: A6NI15
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM