A6NI15 (MSGN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mesogenin-1

Alternative name(s):
Paraxial mesoderm-specific mesogenin1
pMesogenin1
Short name=pMsgn1

Gene names

Name:

MSGN1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW segment specification Inferred from electronic annotation. Source: Compara somitogenesis Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Mesogenin-1		PRO_0000330028
Regions
	Domain	124 – 178	55	bHLH
Natural variations
	Natural variant	80	1	E → D. Corresponds to variant rs34069439 [ dbSNP | Ensembl ].		VAR_061259
	Natural variant	104	1	H → Y. Corresponds to variant rs35858730 [ dbSNP | Ensembl ].		VAR_061260

Sequences

	Sequence		Length	Mass (Da)
	A6NI15 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: B57034F9C39C84B1	FASTA	193	20,778
	10 20 30 40 50 60 MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA PSLESYSSSP 70 80 90 100 110 120 CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF QPTHLQGGGG PKAQKGTKVR 130 140 150 160 170 180 MSVQRRRKAS EREKLRMRTL ADALHTLRNY LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD 190 LLNRGREPRA QSA

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC093731 Genomic DNA. No translation available.
IPI	IPI00247733.
RefSeq	NP_001099039.1. NM_001105569.1.
UniGene	Hs.705359.
3D structure databases
ProteinModelPortal	A6NI15.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000281047.
PTM databases
PhosphoSite	A6NI15.
Proteomic databases
PaxDb	A6NI15.
PRIDE	A6NI15.
Protocols and materials databases
DNASU	343930.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000281047; ENSP00000281047; ENSG00000151379.
GeneID	343930.
KEGG	hsa:343930.
UCSC	uc010yjt.2. human.
Organism-specific databases
CTD	343930.
GeneCards	GC02P017997.
HGNC	HGNC:14907. MSGN1.
MIM	612209. gene.
neXtProt	NX_A6NI15.
PharmGKB	PA142671315.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254790.
HOGENOM	HOG000070445.
HOVERGEN	HBG105692.
InParanoid	A6NI15.
KO	K09077.
OMA	FELNQAS.
OrthoDB	EOG4NGGP8.
Gene expression databases
Bgee	A6NI15.
CleanEx	HS_MSGN1.
Genevestigator	A6NI15.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. [Graphical view]
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	343930.
NextBio	98611.
SOURCE	Search...

Entry information

Entry name

MSGN1_HUMAN

Accession

Primary (citable) accession number: A6NI15

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.