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Protein

Leucine-rich repeat-containing protein 14B

Gene

LRRC14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14BCurated
Gene namesi
Name:LRRC14BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000185028.3.
HGNCiHGNC:37268. LRRC14B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185028.

Polymorphism and mutation databases

BioMutaiLRRC14B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442401 – 514Leucine-rich repeat-containing protein 14BAdd BLAST514

Proteomic databases

PaxDbiA6NHZ5.
PRIDEiA6NHZ5.

PTM databases

iPTMnetiA6NHZ5.
PhosphoSitePlusiA6NHZ5.
SwissPalmiA6NHZ5.

Expressioni

Gene expression databases

BgeeiENSG00000185028.
GenevisibleiA6NHZ5. HS.

Organism-specific databases

HPAiHPA038046.
HPA038047.

Structurei

3D structure databases

ProteinModelPortaliA6NHZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 141LRR 1; degenerateBy similarityAdd BLAST38
Repeati185 – 209LRR 2; degenerateBy similarityAdd BLAST25
Repeati238 – 277LRR 4; degenerateBy similarityAdd BLAST40
Repeati278 – 302LRR 5By similarityAdd BLAST25
Repeati303 – 334LRR 6By similarityAdd BLAST32
Repeati335 – 350LRR 7By similarityAdd BLAST16
Repeati359 – 386LRR 8By similarityAdd BLAST28
Repeati387 – 411LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHBR. Eukaryota.
ENOG410Z0VD. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113360.
HOVERGENiHBG083227.
InParanoidiA6NHZ5.
OMAiWPLEEFR.
OrthoDBiEOG091G04TD.
PhylomeDBiA6NHZ5.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. LRR_dom_sf.

Sequencei

Sequence statusi: Complete.

A6NHZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTMRSLRFI SAEALVSHPQ VARQSLDSVA HNLYPLLFKA SYLLEQAEVT
60 70 80 90 100
RAVLGRWPLE EFRLGALLGP GADHPQDLRD RTCRACLEAL VRGLADHVLQ
110 120 130 140 150
DRSRRRLRVA DLTGIRDVQV QRCPCGRALG RWGRTQLLAR TCCELQAEPL
160 170 180 190 200
AAGRPVEVLA DLFVTEGNFE AVVQALRPAG PAPLRVHCPS FRADSLSPSQ
210 220 230 240 250
LLHVLRLAGP GALRKLEVVH NVRLHAGHVQ QLLAQVGFPR LASLTLPTKA
260 270 280 290 300
FDAPPTYAST PDGEDPLLAS IARELSKMAQ LTELSVAFST LTGKIPTLLG
310 320 330 340 350
PLQTPLRVLD LANCALNHTD MAFLADCAHA AHLEVLDLSG HNLVSLYPST
360 370 380 390 400
FFRLLSQASR TLRILTLEEC GIVDSHVGML ILGLSPCHRL RQLKFLGNPL
410 420 430 440 450
SARALRRLFT ALCELPELRC IEFPVPKDCY PEGAAYPQDE LAMSKFNQQK
460 470 480 490 500
YDEIAEELRA VLLRADREDI QVSTPLFGSF DPDIQETSNE LGAFLLQAFK
510
TALENFSRAL KQIE
Length:514
Mass (Da):56,758
Last modified:April 5, 2011 - v3
Checksum:i61F7F004766CF7C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021087 Genomic DNA. No translation available.
CCDSiCCDS47184.1.
RefSeqiNP_001073947.1. NM_001080478.2.

Genome annotation databases

EnsembliENST00000328278; ENSP00000327675; ENSG00000185028.
GeneIDi389257.
KEGGihsa:389257.
UCSCiuc003jal.1. human.

Similar proteinsi

Entry informationi

Entry nameiLR14B_HUMAN
AccessioniPrimary (citable) accession number: A6NHZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 73 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families