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Protein

Leucine-rich repeat-containing protein 14B

Gene

LRRC14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-30920-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14B
Gene namesi
Name:LRRC14B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:37268. LRRC14B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185028.

Polymorphism and mutation databases

BioMutaiLRRC14B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442401 – 514Leucine-rich repeat-containing protein 14BAdd BLAST514

Proteomic databases

PaxDbiA6NHZ5.
PRIDEiA6NHZ5.

PTM databases

iPTMnetiA6NHZ5.
PhosphoSitePlusiA6NHZ5.
SwissPalmiA6NHZ5.

Expressioni

Gene expression databases

BgeeiENSG00000185028.
GenevisibleiA6NHZ5. HS.

Organism-specific databases

HPAiHPA038046.
HPA038047.

Structurei

3D structure databases

ProteinModelPortaliA6NHZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati277 – 299LRR 1Add BLAST23
Repeati302 – 322LRR 2Add BLAST21
Repeati329 – 350LRR 3Add BLAST22
Repeati358 – 378LRR 4Add BLAST21
Repeati386 – 406LRR 5Add BLAST21

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHBR. Eukaryota.
ENOG410Z0VD. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113360.
HOVERGENiHBG083227.
InParanoidiA6NHZ5.
OMAiWPLEEFR.
OrthoDBiEOG091G04TD.
PhylomeDBiA6NHZ5.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTMRSLRFI SAEALVSHPQ VARQSLDSVA HNLYPLLFKA SYLLEQAEVT
60 70 80 90 100
RAVLGRWPLE EFRLGALLGP GADHPQDLRD RTCRACLEAL VRGLADHVLQ
110 120 130 140 150
DRSRRRLRVA DLTGIRDVQV QRCPCGRALG RWGRTQLLAR TCCELQAEPL
160 170 180 190 200
AAGRPVEVLA DLFVTEGNFE AVVQALRPAG PAPLRVHCPS FRADSLSPSQ
210 220 230 240 250
LLHVLRLAGP GALRKLEVVH NVRLHAGHVQ QLLAQVGFPR LASLTLPTKA
260 270 280 290 300
FDAPPTYAST PDGEDPLLAS IARELSKMAQ LTELSVAFST LTGKIPTLLG
310 320 330 340 350
PLQTPLRVLD LANCALNHTD MAFLADCAHA AHLEVLDLSG HNLVSLYPST
360 370 380 390 400
FFRLLSQASR TLRILTLEEC GIVDSHVGML ILGLSPCHRL RQLKFLGNPL
410 420 430 440 450
SARALRRLFT ALCELPELRC IEFPVPKDCY PEGAAYPQDE LAMSKFNQQK
460 470 480 490 500
YDEIAEELRA VLLRADREDI QVSTPLFGSF DPDIQETSNE LGAFLLQAFK
510
TALENFSRAL KQIE
Length:514
Mass (Da):56,758
Last modified:April 5, 2011 - v3
Checksum:i61F7F004766CF7C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021087 Genomic DNA. No translation available.
CCDSiCCDS47184.1.
RefSeqiNP_001073947.1. NM_001080478.1.
UniGeneiHs.683662.

Genome annotation databases

EnsembliENST00000328278; ENSP00000327675; ENSG00000185028.
GeneIDi389257.
KEGGihsa:389257.
UCSCiuc003jal.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021087 Genomic DNA. No translation available.
CCDSiCCDS47184.1.
RefSeqiNP_001073947.1. NM_001080478.1.
UniGeneiHs.683662.

3D structure databases

ProteinModelPortaliA6NHZ5.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NHZ5.
PhosphoSitePlusiA6NHZ5.
SwissPalmiA6NHZ5.

Polymorphism and mutation databases

BioMutaiLRRC14B.

Proteomic databases

PaxDbiA6NHZ5.
PRIDEiA6NHZ5.

Protocols and materials databases

DNASUi389257.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328278; ENSP00000327675; ENSG00000185028.
GeneIDi389257.
KEGGihsa:389257.
UCSCiuc003jal.1. human.

Organism-specific databases

CTDi389257.
GeneCardsiLRRC14B.
HGNCiHGNC:37268. LRRC14B.
HPAiHPA038046.
HPA038047.
neXtProtiNX_A6NHZ5.
OpenTargetsiENSG00000185028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBR. Eukaryota.
ENOG410Z0VD. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113360.
HOVERGENiHBG083227.
InParanoidiA6NHZ5.
OMAiWPLEEFR.
OrthoDBiEOG091G04TD.
PhylomeDBiA6NHZ5.
TreeFamiTF332708.

Enzyme and pathway databases

BioCyciZFISH:G66-30920-MONOMER.

Miscellaneous databases

GenomeRNAii389257.
PROiA6NHZ5.

Gene expression databases

BgeeiENSG00000185028.
GenevisibleiA6NHZ5. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLR14B_HUMAN
AccessioniPrimary (citable) accession number: A6NHZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.