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Protein

Ankyrin repeat and death domain-containing protein 1B

Gene

ANKDD1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and death domain-containing protein 1B
Gene namesi
Name:ANKDD1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:32525. ANKDD1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Ankyrin repeat and death domain-containing protein 1BPRO_0000332160Add
BLAST

Proteomic databases

PaxDbiA6NHY2.
PRIDEiA6NHY2.

PTM databases

iPTMnetiA6NHY2.
PhosphoSiteiA6NHY2.

Expressioni

Gene expression databases

BgeeiENSG00000189045.

Organism-specific databases

HPAiHPA059722.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000471417.

Structurei

3D structure databases

ProteinModelPortaliA6NHY2.
SMRiA6NHY2. Positions 17-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati67 – 9630ANK 1Add
BLAST
Repeati100 – 12930ANK 2Add
BLAST
Repeati133 – 16230ANK 3Add
BLAST
Repeati166 – 19732ANK 4Add
BLAST
Repeati201 – 23030ANK 5Add
BLAST
Repeati234 – 26330ANK 6Add
BLAST
Repeati267 – 29630ANK 7Add
BLAST
Repeati300 – 32930ANK 8Add
BLAST
Repeati333 – 36230ANK 9Add
BLAST
Repeati366 – 39530ANK 10Add
BLAST
Domaini427 – 51589DeathPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 ANK repeats.PROSITE-ProRule annotation
Contains 1 death domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000122981.
HOVERGENiHBG100885.
InParanoidiA6NHY2.
OMAiGADQKAK.
OrthoDBiEOG091G0IU8.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPAGRARGQ GATAGGLLLR AAAAAKGLRE DLWGAAALPW RSLSRIPKRE
60 70 80 90 100
GLGEEDTAVA GHELLLPNER SFQNAAKSNN LDLMEKLFEK KVNINVVNNM
110 120 130 140 150
NRTALHFAVG RNHLSAVDFL LKHKARVDVA DKHGLTVIHL AAWSGSLEVM
160 170 180 190 200
LMLVKAGADQ RAKNQDGMSA LHFATQSNHV RIVEYLIQDL HLKDLNQPDE
210 220 230 240 250
KGRKPFLLAA ERGHVEMIEK LTFLNLHTSE KDKGGNTALH LAAKHGHSPA
260 270 280 290 300
VQVLLAQWQD INEMNELNIS SLQIATRNGH ASLVNFLLSE NVDLHQKVEP
310 320 330 340 350
KESPLHLVVI NNHITVVNSL LSAQHDIDIL NQKQQTPLHV AADRGNVELV
360 370 380 390 400
ETLLKAGCDL KAVDKQGKTA LAVASRSNHS LVVGMLIKAE RYYAWREEHH
410 420 430 440 450
ESIRDPSTGF TLTFKQDHSL ETRHIRTLLW DLAYHQLKAN EWQRLARSWN
460 470 480 490 500
FTDDQIRAIE EQWSGNESFR EHGHRALLIW LHGTLMTQGD PAKQLYEELV
510 520
HAGFPKLAEK TRHFKSKTDS NSKKCVVS
Length:528
Mass (Da):59,088
Last modified:April 3, 2013 - v3
Checksum:i5C3FF9A1A2A54859
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010245 Genomic DNA. No translation available.
CCDSiCCDS64180.1.
RefSeqiNP_001263642.1. NM_001276713.1.
UniGeneiHs.370455.

Genome annotation databases

EnsembliENST00000601380; ENSP00000471417; ENSG00000189045.
GeneIDi728780.
KEGGihsa:728780.
UCSCiuc031ski.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010245 Genomic DNA. No translation available.
CCDSiCCDS64180.1.
RefSeqiNP_001263642.1. NM_001276713.1.
UniGeneiHs.370455.

3D structure databases

ProteinModelPortaliA6NHY2.
SMRiA6NHY2. Positions 17-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000471417.

PTM databases

iPTMnetiA6NHY2.
PhosphoSiteiA6NHY2.

Proteomic databases

PaxDbiA6NHY2.
PRIDEiA6NHY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000601380; ENSP00000471417; ENSG00000189045.
GeneIDi728780.
KEGGihsa:728780.
UCSCiuc031ski.2. human.

Organism-specific databases

CTDi728780.
GeneCardsiANKDD1B.
HGNCiHGNC:32525. ANKDD1B.
HPAiHPA059722.
neXtProtiNX_A6NHY2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000122981.
HOVERGENiHBG100885.
InParanoidiA6NHY2.
OMAiGADQKAK.
OrthoDBiEOG091G0IU8.

Miscellaneous databases

GenomeRNAii728780.
PROiA6NHY2.

Gene expression databases

BgeeiENSG00000189045.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKD1B_HUMAN
AccessioniPrimary (citable) accession number: A6NHY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 3, 2013
Last modified: September 7, 2016
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.