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Protein

Cytosolic arginine sensor for mTORC1 subunit 2

Gene

CASTOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • negative regulation of TORC1 signaling Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic arginine sensor for mTORC1 subunit 2Imported
Alternative name(s):
Cellular arginine sensor for mTORC1 protein 21 Publication
GATS-like protein 2Curated
Gene namesi
Name:CASTOR21 PublicationImported
Synonyms:GATSL1Imported, GATSL2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000274070.1.
HGNCiHGNC:37073. CASTOR2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000274070.
PharmGKBiPA164720214.
PA164720237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003413041 – 329Cytosolic arginine sensor for mTORC1 subunit 2Add BLAST329

Proteomic databases

EPDiA6NHX0.
MaxQBiA6NHX0.
PaxDbiA6NHX0.
PRIDEiA6NHX0.

PTM databases

iPTMnetiA6NHX0.
PhosphoSitePlusiA6NHX0.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000274070.

Organism-specific databases

HPAiHPA057229.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with CASTOR1 (PubMed:26972053). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by arginine (PubMed:26972053).1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi609839. 6 interactors.
DIPiDIP-62097N.
IntActiA6NHX0. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA6NHX0.
SMRiA6NHX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 140ACT 1Add BLAST69
Domaini262 – 322ACT 2Add BLAST61

Sequence similaritiesi

Belongs to the GATS family.Curated

Phylogenomic databases

eggNOGiENOG410IJ9B. Eukaryota.
ENOG4111D5N. LUCA.
GeneTreeiENSGT00390000006208.
HOVERGENiHBG107937.
InParanoidiA6NHX0.
OMAiFVKPKMV.
OrthoDBiEOG091G0GYO.
PhylomeDBiA6NHX0.
TreeFamiTF331648.

Family and domain databases

InterProiView protein in InterPro
IPR026249. GATS-like.
IPR027795. GATS-like_ACT_dom.
PfamiView protein in Pfam
PF13840. ACT_7. 2 hits.
PRINTSiPR02078. GATSLIKEFMLY.

Sequencei

Sequence statusi: Complete.

A6NHX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELHILEHRL QVASVAKESI PLFTYGLIKL AFLSSKTRCK FFSLTETPED
60 70 80 90 100
YTIIVDEEGF LELPSSEHLS VADATWLALN VVSGGGSFSS SQPIGVTKIA
110 120 130 140 150
KSVIAPLADQ NISVFMLSTY QTDFILVRER DLPFVTHTLS SEFTILRVVN
160 170 180 190 200
GETVAAENLG ITNGFVKPKL VQRPVIHPLS SPSNRFCVTS LDPDTLPAVA
210 220 230 240 250
TLLMDVMFYS NGVKDPMATG DDCGHIRFFS FSLIEGYISL VMDVQTQQRF
260 270 280 290 300
PSNLLFTSAS GELWKMVRIG GQPLGFDECG IVAQISEPLA AADIPAYYIS
310 320
TFKFDHALVP EENINGVISA LKVSQAEKH
Length:329
Mass (Da):36,056
Last modified:June 10, 2008 - v3
Checksum:iBC86CEFC0FBC21B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245150 Genomic DNA. No translation available.
BC147030 mRNA. Translation: AAI47031.1.
BC147031 mRNA. Translation: AAI47032.1.
BC150658 mRNA. Translation: AAI50659.1.
CCDSiCCDS75620.1.
RefSeqiNP_001138536.1. NM_001145064.2.
UniGeneiHs.594823.
Hs.647031.
Hs.647048.
Hs.647505.
Hs.728007.

Genome annotation databases

EnsembliENST00000616305; ENSP00000484732; ENSG00000274070.
GeneIDi729438.
KEGGihsa:729438.
UCSCiuc003ucg.4. human.

Similar proteinsi

Entry informationi

Entry nameiCAST2_HUMAN
AccessioniPrimary (citable) accession number: A6NHX0
Secondary accession number(s): A6NNH0, B9EJH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 27, 2017
This is version 77 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families