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Protein
Submitted name:

SH3 and multiple ankyrin repeat domains protein 2

Gene

SHANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
SH3 and multiple ankyrin repeat domains protein 2Imported
Gene namesi
Name:SHANK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14295. SHANK2.

PTM / Processingi

Proteomic databases

PaxDbiA6NHU9.
PRIDEiA6NHU9.

Expressioni

Gene expression databases

BgeeiA6NHU9.
ExpressionAtlasiA6NHU9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345193.

Structurei

3D structure databases

ProteinModelPortaliA6NHU9.
SMRiA6NHU9. Positions 30-133, 1195-1258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 13295PDZ (DHR)InterPro annotationAdd
BLAST
Domaini1198 – 126164SAM (sterile alpha motif)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4375. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG054027.
TreeFamiTF324593.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMNVPGGGA AAVMMTGYNN GRCPRNSLYS DCIIEEKTVV LQKKDNEGFG
60 70 80 90 100
FVLRGAKADT PIEEFTPTPA FPALQYLESV DEGGVAWQAG LRTGDFLIEV
110 120 130 140 150
NNENVVKVGH RQVVNMIRQG GNHLVLKVVT VTRNLDPDDT ARKKAPPPPK
160 170 180 190 200
RAPTTALTLR SKSMTSELEE LVDKASVRKK KDKPEEIVPA SKPSRAAENM
210 220 230 240 250
AVEPRVATIK QRPSSRCFPA GSDMNSVYER QGIAVMTPTV PGSPKAPFLG
260 270 280 290 300
IPRGTMRRQK SIDSRIFLSG ITEEERQFLA PPMLKFTRSL SMPDTSEDIP
310 320 330 340 350
PPPQSVPPSP PPPSPTTYNC PKSPTPRVYG TIKPAFNQNS AAKVSPATRS
360 370 380 390 400
DTVATMMREK GMYFRRELDR YSLDSEDLYS RNAGPQANFR NKRGQMPENP
410 420 430 440 450
YSEVGKIASK AVYVPAKPAR RKGMLVKQSN VEDSPEKTCS IPIPTIIVKE
460 470 480 490 500
PSTSSSGKSS QGSSMEIDPQ APEPPSQLRP DESLTVSSPF AAAIAGAVRD
510 520 530 540 550
REKRLEARRN SPAFLSTDLG DEDVGLGPPA PRTRPSMFPE EGDFADEDSA
560 570 580 590 600
EQLSSPMPSA TPREPENHFV GGAEASAPGE AGRPLNSTSK AQGPESSPAV
610 620 630 640 650
PSASSGTAGP GNYVHPLTGR LLDPSSPLAL ALSARDRAMK ESQQGPKGEA
660 670 680 690 700
PKADLNKPLY IDTKMRPSLD AGFPTVTRQN TRGPLRRQET ENKYETDLGR
710 720 730 740 750
DRKGDDKKNM LIDIMDTSQQ KSAGLLMVHT VDATKLDNAL QEEDEKAEVE
760 770 780 790 800
MKPDSSPSEV PEGVSETEGA LQISAAPEPT TVPGRTIVAV GSMEEAVILP
810 820 830 840 850
FRIPPPPLAS VDLDEDFIFT EPLPPPLEFA NSFDIPDDRA ASVPALSDLV
860 870 880 890 900
KQKKSDTPQS PSLNSSQPTN SADSKKPASL SNCLPASFLP PPESFDAVAD
910 920 930 940 950
SGIEEVDSRS SSDHHLETTS TISTVSSIST LSSEGGENVD TCTVYADGQA
960 970 980 990 1000
FMVDKPPVPP KPKMKPIIHK SNALYQDALV EEDVDSFVIP PPAPPPPPGS
1010 1020 1030 1040 1050
AQPGMAKVLQ PRTSKLWGDV TEIKSPILSG PKANVISELN SILQQMNREK
1060 1070 1080 1090 1100
LAKPGEGLDS PMGAKSASLA PRSPEIMSTI SGTRSTTVTF TVRPGTSQPI
1110 1120 1130 1140 1150
TLQSRPPDYE SRTSGTRRAP SPVVSPTEMN KETLPAPLSA ATASPSPALS
1160 1170 1180 1190 1200
DVFSLPSQPP SGDLFGLNPA GRSRSPSPSI LQQPISNKPF TTKPVHLWTK
1210 1220 1230 1240 1250
PDVADWLESL NLGEHKEAFM DNEIDGSHLP NLQKEDLIDL GVTRVGHRMN
1260
IERALKQLLD R
Length:1,261
Mass (Da):135,729
Last modified:November 26, 2014 - v5
Checksum:iF2E8890D0CE70C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC234421 Genomic DNA. No translation available.
AP000590 Genomic DNA. No translation available.
AP001271 Genomic DNA. No translation available.
AP001648 Genomic DNA. No translation available.
AP003783 Genomic DNA. No translation available.
AP003967 Genomic DNA. No translation available.
AP004370 Genomic DNA. No translation available.
AP005401 Genomic DNA. No translation available.
KF455409 Genomic DNA. No translation available.
RefSeqiNP_573573.2. NM_133266.4.
UniGeneiHs.268726.

Genome annotation databases

EnsembliENST00000338508; ENSP00000345193; ENSG00000162105.
GeneIDi22941.
UCSCiuc058eto.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC234421 Genomic DNA. No translation available.
AP000590 Genomic DNA. No translation available.
AP001271 Genomic DNA. No translation available.
AP001648 Genomic DNA. No translation available.
AP003783 Genomic DNA. No translation available.
AP003967 Genomic DNA. No translation available.
AP004370 Genomic DNA. No translation available.
AP005401 Genomic DNA. No translation available.
KF455409 Genomic DNA. No translation available.
RefSeqiNP_573573.2. NM_133266.4.
UniGeneiHs.268726.

3D structure databases

ProteinModelPortaliA6NHU9.
SMRiA6NHU9. Positions 30-133, 1195-1258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345193.

Proteomic databases

PaxDbiA6NHU9.
PRIDEiA6NHU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338508; ENSP00000345193; ENSG00000162105.
GeneIDi22941.
UCSCiuc058eto.1. human.

Organism-specific databases

CTDi22941.
HGNCiHGNC:14295. SHANK2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4375. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG054027.
TreeFamiTF324593.

Miscellaneous databases

ChiTaRSiSHANK2. human.
GenomeRNAii22941.

Gene expression databases

BgeeiA6NHU9.
ExpressionAtlasiA6NHU9. baseline and differential.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA6NHU9_HUMAN
AccessioniPrimary (citable) accession number: A6NHU9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: November 26, 2014
Last modified: June 8, 2016
This is version 76 of the entry and version 5 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.