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A6NHS7 (MANS4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MANSC domain-containing protein 4
Gene names
Name:MANSC4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Contains 1 MANSC domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 340316MANSC domain-containing protein 4
PRO_0000349176

Regions

Topological domain25 – 284260Extracellular Potential
Transmembrane285 – 30521Helical; Potential
Topological domain306 – 34035Cytoplasmic Potential
Domain37 – 11781MANSC

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A6NHS7 [UniParc].

Last modified October 31, 2012. Version 3.
Checksum: 4C5393FDA04AFB87

FASTA34037,879
        10         20         30         40         50         60 
MHVAEVAVNV ILLLSMGWTS DSLCSPTIFY RDCWIRRFPG LLINLEESQK LGAQFLKYYS 

        70         80         90        100        110        120 
ESTGQKCSRS CCLRKDVSCN LAVFYHSPIH DNINCLHVHC PTLESCILEP GTSAILYNIT 

       130        140        150        160        170        180 
DGIDPDLLVF EQSPTYLNTR SSSNRWDRLR ILKAMNLDKQ TTTINGMLPS TEAPSSTTHQ 

       190        200        210        220        230        240 
DLVVNTNSTS YSKELTTDFW ARFTSLNESI TTKINKVSPS TDFISNPDNK TISPFFEPID 

       250        260        270        280        290        300 
TKLSHMPVPP GLNSSKQLLN KTKGYNSRNH TSANEDEVSV TSKTWLVSVA LCTSVIFLGC 

       310        320        330        340 
CIVILASGCC GKQQGQYKPG QRKSGSLQIK NRNHMKENSS 

« Hide

References

[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC009509 Genomic DNA. No translation available.
RefSeqNP_001139693.1. NM_001146221.1.
UniGeneHs.202178.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA6NHS7.

Proteomic databases

PaxDbA6NHS7.
PRIDEA6NHS7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381273; ENSP00000370673; ENSG00000205693.
GeneID100287284.
KEGGhsa:100287284.
UCSCuc010sjs.1. human.

Organism-specific databases

CTD100287284.
GeneCardsGC12M027917.
HGNCHGNC:40023. MANSC4.
HPAHPA039454.
HPA039682.
neXtProtNX_A6NHS7.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG120738.
HOVERGENHBG108731.
InParanoidA6NHS7.
OMAGAQFLKY.
OrthoDBEOG7CVQ03.
TreeFamTF353070.

Gene expression databases

BgeeA6NHS7.
GenevestigatorA6NHS7.

Family and domain databases

InterProIPR013980. MANSC.
IPR011106. MANSC_N.
[Graphical view]
PfamPF07502. MANEC. 1 hit.
[Graphical view]
SMARTSM00765. MANEC. 1 hit.
[Graphical view]
PROSITEPS50986. MANSC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROA6NHS7.

Entry information

Entry nameMANS4_HUMAN
AccessionPrimary (citable) accession number: A6NHS7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 31, 2012
Last modified: February 19, 2014
This is version 42 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM