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Protein

MANSC domain-containing protein 4

Gene

MANSC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
MANSC domain-containing protein 4
Gene namesi
Name:MANSC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:40023. MANSC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 284260ExtracellularSequence AnalysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Topological domaini306 – 34035CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 340316MANSC domain-containing protein 4PRO_0000349176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6NHS7.
PRIDEiA6NHS7.

PTM databases

PhosphoSiteiA6NHS7.

Expressioni

Gene expression databases

BgeeiA6NHS7.
GenevestigatoriA6NHS7.

Organism-specific databases

HPAiHPA039454.
HPA039682.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 11781MANSCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MANSC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG120738.
GeneTreeiENSGT00390000000167.
HOVERGENiHBG108731.
InParanoidiA6NHS7.
OMAiFPGLLID.
OrthoDBiEOG7CVQ03.
PhylomeDBiA6NHS7.
TreeFamiTF353070.

Family and domain databases

InterProiIPR013980. MANSC.
IPR011106. MANSC_N.
[Graphical view]
PfamiPF07502. MANEC. 1 hit.
[Graphical view]
SMARTiSM00765. MANEC. 1 hit.
[Graphical view]
PROSITEiPS50986. MANSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NHS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVAEVAVNV ILLLSMGWTS DSLCSPTIFY RDCWIRRFPG LLINLEESQK
60 70 80 90 100
LGAQFLKYYS ESTGQKCSRS CCLRKDVSCN LAVFYHSPIH DNINCLHVHC
110 120 130 140 150
PTLESCILEP GTSAILYNIT DGIDPDLLVF EQSPTYLNTR SSSNRWDRLR
160 170 180 190 200
ILKAMNLDKQ TTTINGMLPS TEAPSSTTHQ DLVVNTNSTS YSKELTTDFW
210 220 230 240 250
ARFTSLNESI TTKINKVSPS TDFISNPDNK TISPFFEPID TKLSHMPVPP
260 270 280 290 300
GLNSSKQLLN KTKGYNSRNH TSANEDEVSV TSKTWLVSVA LCTSVIFLGC
310 320 330 340
CIVILASGCC GKQQGQYKPG QRKSGSLQIK NRNHMKENSS
Length:340
Mass (Da):37,879
Last modified:October 31, 2012 - v3
Checksum:i4C5393FDA04AFB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009509 Genomic DNA. No translation available.
CCDSiCCDS53770.1.
RefSeqiNP_001139693.1. NM_001146221.1.
UniGeneiHs.202178.

Genome annotation databases

EnsembliENST00000381273; ENSP00000370673; ENSG00000205693.
GeneIDi100287284.
KEGGihsa:100287284.
UCSCiuc010sjs.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009509 Genomic DNA. No translation available.
CCDSiCCDS53770.1.
RefSeqiNP_001139693.1. NM_001146221.1.
UniGeneiHs.202178.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA6NHS7.

Proteomic databases

PaxDbiA6NHS7.
PRIDEiA6NHS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381273; ENSP00000370673; ENSG00000205693.
GeneIDi100287284.
KEGGihsa:100287284.
UCSCiuc010sjs.1. human.

Organism-specific databases

CTDi100287284.
GeneCardsiGC12M027917.
HGNCiHGNC:40023. MANSC4.
HPAiHPA039454.
HPA039682.
neXtProtiNX_A6NHS7.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG120738.
GeneTreeiENSGT00390000000167.
HOVERGENiHBG108731.
InParanoidiA6NHS7.
OMAiFPGLLID.
OrthoDBiEOG7CVQ03.
PhylomeDBiA6NHS7.
TreeFamiTF353070.

Miscellaneous databases

PROiA6NHS7.

Gene expression databases

BgeeiA6NHS7.
GenevestigatoriA6NHS7.

Family and domain databases

InterProiIPR013980. MANSC.
IPR011106. MANSC_N.
[Graphical view]
PfamiPF07502. MANEC. 1 hit.
[Graphical view]
SMARTiSM00765. MANEC. 1 hit.
[Graphical view]
PROSITEiPS50986. MANSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMANS4_HUMAN
AccessioniPrimary (citable) accession number: A6NHS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 31, 2012
Last modified: January 7, 2015
This is version 47 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.