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A6NHS7

- MANS4_HUMAN

UniProt

A6NHS7 - MANS4_HUMAN

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Protein
MANSC domain-containing protein 4
Gene
MANSC4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
MANSC domain-containing protein 4
Gene namesi
Name:MANSC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:40023. MANSC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 284260Extracellular Reviewed prediction
Add
BLAST
Transmembranei285 – 30521Helical; Reviewed prediction
Add
BLAST
Topological domaini306 – 34035Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 340316MANSC domain-containing protein 4
PRO_0000349176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6NHS7.
PRIDEiA6NHS7.

PTM databases

PhosphoSiteiA6NHS7.

Expressioni

Gene expression databases

BgeeiA6NHS7.
GenevestigatoriA6NHS7.

Organism-specific databases

HPAiHPA039454.
HPA039682.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 11781MANSC
Add
BLAST

Sequence similaritiesi

Contains 1 MANSC domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG120738.
HOVERGENiHBG108731.
InParanoidiA6NHS7.
OMAiLLVFEQS.
OrthoDBiEOG7CVQ03.
PhylomeDBiA6NHS7.
TreeFamiTF353070.

Family and domain databases

InterProiIPR013980. MANSC.
IPR011106. MANSC_N.
[Graphical view]
PfamiPF07502. MANEC. 1 hit.
[Graphical view]
SMARTiSM00765. MANEC. 1 hit.
[Graphical view]
PROSITEiPS50986. MANSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NHS7-1 [UniParc]FASTAAdd to Basket

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MHVAEVAVNV ILLLSMGWTS DSLCSPTIFY RDCWIRRFPG LLINLEESQK    50
LGAQFLKYYS ESTGQKCSRS CCLRKDVSCN LAVFYHSPIH DNINCLHVHC 100
PTLESCILEP GTSAILYNIT DGIDPDLLVF EQSPTYLNTR SSSNRWDRLR 150
ILKAMNLDKQ TTTINGMLPS TEAPSSTTHQ DLVVNTNSTS YSKELTTDFW 200
ARFTSLNESI TTKINKVSPS TDFISNPDNK TISPFFEPID TKLSHMPVPP 250
GLNSSKQLLN KTKGYNSRNH TSANEDEVSV TSKTWLVSVA LCTSVIFLGC 300
CIVILASGCC GKQQGQYKPG QRKSGSLQIK NRNHMKENSS 340
Length:340
Mass (Da):37,879
Last modified:October 31, 2012 - v3
Checksum:i4C5393FDA04AFB87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009509 Genomic DNA. No translation available.
CCDSiCCDS53770.1.
RefSeqiNP_001139693.1. NM_001146221.1.
UniGeneiHs.202178.

Genome annotation databases

EnsembliENST00000381273; ENSP00000370673; ENSG00000205693.
GeneIDi100287284.
KEGGihsa:100287284.
UCSCiuc010sjs.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009509 Genomic DNA. No translation available.
CCDSi CCDS53770.1.
RefSeqi NP_001139693.1. NM_001146221.1.
UniGenei Hs.202178.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A6NHS7.

Proteomic databases

PaxDbi A6NHS7.
PRIDEi A6NHS7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381273 ; ENSP00000370673 ; ENSG00000205693 .
GeneIDi 100287284.
KEGGi hsa:100287284.
UCSCi uc010sjs.1. human.

Organism-specific databases

CTDi 100287284.
GeneCardsi GC12M027917.
HGNCi HGNC:40023. MANSC4.
HPAi HPA039454.
HPA039682.
neXtProti NX_A6NHS7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG120738.
HOVERGENi HBG108731.
InParanoidi A6NHS7.
OMAi LLVFEQS.
OrthoDBi EOG7CVQ03.
PhylomeDBi A6NHS7.
TreeFami TF353070.

Miscellaneous databases

PROi A6NHS7.

Gene expression databases

Bgeei A6NHS7.
Genevestigatori A6NHS7.

Family and domain databases

InterProi IPR013980. MANSC.
IPR011106. MANSC_N.
[Graphical view ]
Pfami PF07502. MANEC. 1 hit.
[Graphical view ]
SMARTi SM00765. MANEC. 1 hit.
[Graphical view ]
PROSITEi PS50986. MANSC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMANS4_HUMAN
AccessioniPrimary (citable) accession number: A6NHS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 31, 2012
Last modified: July 9, 2014
This is version 44 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi