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A6NHS7

- MANS4_HUMAN

UniProt

A6NHS7 - MANS4_HUMAN

Protein

MANSC domain-containing protein 4

Gene

MANSC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 3 (31 Oct 2012)
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MANSC domain-containing protein 4
    Gene namesi
    Name:MANSC4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:40023. MANSC4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 340316MANSC domain-containing protein 4PRO_0000349176Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiA6NHS7.
    PRIDEiA6NHS7.

    PTM databases

    PhosphoSiteiA6NHS7.

    Expressioni

    Gene expression databases

    BgeeiA6NHS7.
    GenevestigatoriA6NHS7.

    Organism-specific databases

    HPAiHPA039454.
    HPA039682.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 284260ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 34035CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 11781MANSCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MANSC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG120738.
    HOVERGENiHBG108731.
    InParanoidiA6NHS7.
    OMAiLLVFEQS.
    OrthoDBiEOG7CVQ03.
    PhylomeDBiA6NHS7.
    TreeFamiTF353070.

    Family and domain databases

    InterProiIPR013980. MANSC.
    IPR011106. MANSC_N.
    [Graphical view]
    PfamiPF07502. MANEC. 1 hit.
    [Graphical view]
    SMARTiSM00765. MANEC. 1 hit.
    [Graphical view]
    PROSITEiPS50986. MANSC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6NHS7-1 [UniParc]FASTAAdd to Basket

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    MHVAEVAVNV ILLLSMGWTS DSLCSPTIFY RDCWIRRFPG LLINLEESQK    50
    LGAQFLKYYS ESTGQKCSRS CCLRKDVSCN LAVFYHSPIH DNINCLHVHC 100
    PTLESCILEP GTSAILYNIT DGIDPDLLVF EQSPTYLNTR SSSNRWDRLR 150
    ILKAMNLDKQ TTTINGMLPS TEAPSSTTHQ DLVVNTNSTS YSKELTTDFW 200
    ARFTSLNESI TTKINKVSPS TDFISNPDNK TISPFFEPID TKLSHMPVPP 250
    GLNSSKQLLN KTKGYNSRNH TSANEDEVSV TSKTWLVSVA LCTSVIFLGC 300
    CIVILASGCC GKQQGQYKPG QRKSGSLQIK NRNHMKENSS 340
    Length:340
    Mass (Da):37,879
    Last modified:October 31, 2012 - v3
    Checksum:i4C5393FDA04AFB87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009509 Genomic DNA. No translation available.
    CCDSiCCDS53770.1.
    RefSeqiNP_001139693.1. NM_001146221.1.
    UniGeneiHs.202178.

    Genome annotation databases

    EnsembliENST00000381273; ENSP00000370673; ENSG00000205693.
    GeneIDi100287284.
    KEGGihsa:100287284.
    UCSCiuc010sjs.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009509 Genomic DNA. No translation available.
    CCDSi CCDS53770.1.
    RefSeqi NP_001139693.1. NM_001146221.1.
    UniGenei Hs.202178.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A6NHS7.

    Proteomic databases

    PaxDbi A6NHS7.
    PRIDEi A6NHS7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381273 ; ENSP00000370673 ; ENSG00000205693 .
    GeneIDi 100287284.
    KEGGi hsa:100287284.
    UCSCi uc010sjs.1. human.

    Organism-specific databases

    CTDi 100287284.
    GeneCardsi GC12M027917.
    HGNCi HGNC:40023. MANSC4.
    HPAi HPA039454.
    HPA039682.
    neXtProti NX_A6NHS7.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG120738.
    HOVERGENi HBG108731.
    InParanoidi A6NHS7.
    OMAi LLVFEQS.
    OrthoDBi EOG7CVQ03.
    PhylomeDBi A6NHS7.
    TreeFami TF353070.

    Miscellaneous databases

    PROi A6NHS7.

    Gene expression databases

    Bgeei A6NHS7.
    Genevestigatori A6NHS7.

    Family and domain databases

    InterProi IPR013980. MANSC.
    IPR011106. MANSC_N.
    [Graphical view ]
    Pfami PF07502. MANEC. 1 hit.
    [Graphical view ]
    SMARTi SM00765. MANEC. 1 hit.
    [Graphical view ]
    PROSITEi PS50986. MANSC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMANS4_HUMAN
    AccessioniPrimary (citable) accession number: A6NHS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 45 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3