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Protein

Elongin BC and Polycomb repressive complex 2-associated protein

Gene

EPOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Elongin BC and Polycomb repressive complex 2-associated proteinBy similarity
Alternative name(s):
Proline-rich protein 28Imported
Gene namesi
Name:EPOPImported
Synonyms:C17orf96Imported, PRR28Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:34493. EPOP.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: Localizes at both PRC2/EED-EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100170841.
OpenTargetsiENSG00000273604.
PharmGKBiPA162378581.

Polymorphism and mutation databases

BioMutaiC17orf96.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321541 – 379Elongin BC and Polycomb repressive complex 2-associated proteinAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei52Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiA6NHQ4.
PaxDbiA6NHQ4.
PRIDEiA6NHQ4.

PTM databases

iPTMnetiA6NHQ4.
PhosphoSitePlusiA6NHQ4.

Expressioni

Gene expression databases

BgeeiENSG00000179294.
CleanExiHS_C17orf96.
GenevisibleiA6NHQ4. HS.

Organism-specific databases

HPAiHPA055190.
HPA056555.

Interactioni

Subunit structurei

Associates with the PRC2/EED-EZH2 complex (PubMed:24550272). Associates with the elongin BC complex (By similarity). Interacts with USP7 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi936860. 5 interactors.
IntActiA6NHQ4. 19 interactors.
STRINGi9606.ENSP00000317905.

Structurei

3D structure databases

ProteinModelPortaliA6NHQ4.
SMRiA6NHQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 48BC-boxBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 367Pro-richAdd BLAST362

Domaini

The BC-box, which mediates binding to the elongin BC complex.By similarity

Phylogenomic databases

eggNOGiENOG410II10. Eukaryota.
ENOG41116AE. LUCA.
GeneTreeiENSGT00530000064183.
HOGENOMiHOG000111944.
HOVERGENiHBG094969.
InParanoidiA6NHQ4.
OMAiFCALAKP.
OrthoDBiEOG091G02LG.
PhylomeDBiA6NHQ4.
TreeFamiTF337589.

Family and domain databases

InterProiView protein in InterPro
IPR027971. EPOP.
PfamiView protein in Pfam
PF15223. DUF4584. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NHQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLCPAPRL AVPASPRGSP CSPTPRKPCR GTQEFSPLCL RALAFCALAK
60 70 80 90 100
PRASSLGPGP GELAARSPVL RGPQAPLRPG GWAPDGLKHL WAPTGRPGVP
110 120 130 140 150
NTAAGEDADV AACPRRGEEE EGGGGFPHFG VRSCAPPGRC PAPPHPREST
160 170 180 190 200
TSFASAPPRP APGLEPQRGP AASPPQEPSS RPPSPPAGLS TEPAGPGTAP
210 220 230 240 250
RPFLPGQPAE VDGNPPPAAP EAPAASPSTA SPAPAAPGDL RQEHFDRLIR
260 270 280 290 300
RSKLWCYAKG FALDTPSLRR GPERPPAKGP ARGAAKKRRL PAPPPRTAQP
310 320 330 340 350
RRPAPTLPTT STFSLLNCFP CPPALVVGED GDLKPASSLR LQGDSKPPPA
360 370
HPLWRWQMGG PAVPEPPGLK FWGINMDES
Length:379
Mass (Da):39,322
Last modified:July 24, 2007 - v1
Checksum:iB79A849C86733102
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006449 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60520.1.
CCDSiCCDS45661.1.
RefSeqiNP_001124149.1. NM_001130677.1.
UniGeneiHs.445574.

Genome annotation databases

EnsembliENST00000613024; ENSP00000483859; ENSG00000277303.
ENST00000621654; ENSP00000484710; ENSG00000273604.
GeneIDi100170841.
KEGGihsa:100170841.
UCSCiuc010wdq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006449 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60520.1.
CCDSiCCDS45661.1.
RefSeqiNP_001124149.1. NM_001130677.1.
UniGeneiHs.445574.

3D structure databases

ProteinModelPortaliA6NHQ4.
SMRiA6NHQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi936860. 5 interactors.
IntActiA6NHQ4. 19 interactors.
STRINGi9606.ENSP00000317905.

PTM databases

iPTMnetiA6NHQ4.
PhosphoSitePlusiA6NHQ4.

Polymorphism and mutation databases

BioMutaiC17orf96.

Proteomic databases

MaxQBiA6NHQ4.
PaxDbiA6NHQ4.
PRIDEiA6NHQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613024; ENSP00000483859; ENSG00000277303.
ENST00000621654; ENSP00000484710; ENSG00000273604.
GeneIDi100170841.
KEGGihsa:100170841.
UCSCiuc010wdq.3. human.

Organism-specific databases

CTDi100170841.
DisGeNETi100170841.
GeneCardsiC17orf96.
H-InvDBiHIX0039237.
HGNCiHGNC:34493. EPOP.
HPAiHPA055190.
HPA056555.
neXtProtiNX_A6NHQ4.
OpenTargetsiENSG00000273604.
PharmGKBiPA162378581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II10. Eukaryota.
ENOG41116AE. LUCA.
GeneTreeiENSGT00530000064183.
HOGENOMiHOG000111944.
HOVERGENiHBG094969.
InParanoidiA6NHQ4.
OMAiFCALAKP.
OrthoDBiEOG091G02LG.
PhylomeDBiA6NHQ4.
TreeFamiTF337589.

Miscellaneous databases

GenomeRNAii100170841.
PROiPR:A6NHQ4.

Gene expression databases

BgeeiENSG00000179294.
CleanExiHS_C17orf96.
GenevisibleiA6NHQ4. HS.

Family and domain databases

InterProiView protein in InterPro
IPR027971. EPOP.
PfamiView protein in Pfam
PF15223. DUF4584. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEPOP_HUMAN
AccessioniPrimary (citable) accession number: A6NHQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: April 12, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.