ID   SPE2B_HUMAN             Reviewed;         402 AA.
AC   A6NHP3; D6RBN0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   27-MAR-2024, entry version 107.
DE   RecName: Full=Speedy protein E2B;
GN   Name=SPDYE2B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A6NHP3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NHP3-2; Sequence=VSP_039852;
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR   EMBL; AC105052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59507.1; -. [A6NHP3-1]
DR   RefSeq; NP_001159811.1; NM_001166339.1. [A6NHP3-1]
DR   RefSeq; XP_005250150.1; XM_005250093.3.
DR   AlphaFoldDB; A6NHP3; -.
DR   BioGRID; 138451; 5.
DR   IntAct; A6NHP3; 1.
DR   STRING; 9606.ENSP00000424058; -.
DR   iPTMnet; A6NHP3; -.
DR   PhosphoSitePlus; A6NHP3; -.
DR   BioMuta; SPDYE2B; -.
DR   MassIVE; A6NHP3; -.
DR   PaxDb; 9606-ENSP00000424058; -.
DR   PeptideAtlas; A6NHP3; -.
DR   Antibodypedia; 74842; 50 antibodies from 10 providers.
DR   DNASU; 100310812; -.
DR   Ensembl; ENST00000436228.6; ENSP00000440393.1; ENSG00000173678.15. [A6NHP3-1]
DR   Ensembl; ENST00000455020.3; ENSP00000414338.2; ENSG00000173678.15. [A6NHP3-2]
DR   Ensembl; ENST00000507450.6; ENSP00000424058.1; ENSG00000173678.15. [A6NHP3-1]
DR   GeneID; 100310812; -.
DR   KEGG; hsa:100310812; -.
DR   MANE-Select; ENST00000507450.6; ENSP00000424058.1; NM_001166339.2; NP_001159811.1.
DR   UCSC; uc011kle.3; human. [A6NHP3-1]
DR   AGR; HGNC:48334; -.
DR   CTD; 100310812; -.
DR   GeneCards; SPDYE2B; -.
DR   HGNC; HGNC:48334; SPDYE2B.
DR   HPA; ENSG00000173678; Tissue enhanced (skeletal muscle, testis).
DR   neXtProt; NX_A6NHP3; -.
DR   OpenTargets; ENSG00000205238; -.
DR   VEuPathDB; HostDB:ENSG00000173678; -.
DR   eggNOG; ENOG502SSQN; Eukaryota.
DR   GeneTree; ENSGT00940000154173; -.
DR   HOGENOM; CLU_070353_0_0_1; -.
DR   InParanoid; A6NHP3; -.
DR   OMA; EAFNSYD; -.
DR   OrthoDB; 4658198at2759; -.
DR   PhylomeDB; A6NHP3; -.
DR   BioGRID-ORCS; 100310812; 43 hits in 664 CRISPR screens.
DR   GenomeRNAi; 100310812; -.
DR   Pharos; A6NHP3; Tdark.
DR   PRO; PR:A6NHP3; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A6NHP3; Protein.
DR   Bgee; ENSG00000173678; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 103 other cell types or tissues.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156:SF15; SPEEDY PROTEIN E10-RELATED; 1.
DR   PANTHER; PTHR31156; WBSCR19-LIKE PROTEIN; 1.
DR   Pfam; PF11357; Spy1; 2.
PE   3: Inferred from homology;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..402
FT                   /note="Speedy protein E2B"
FT                   /id="PRO_0000399479"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..144
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_039852"
SQ   SEQUENCE   402 AA;  48290 MW;  282148A87EC8A6BD CRC64;
     MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML GPSAPGVDPS
     PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSSILPEHHK
     DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
     MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
     WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR
     KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR KNRSQIVLFQ
     KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH LS
//