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Protein

Speedy protein E2B

Gene

SPDYE2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Speedy protein E2B
Gene namesi
Name:SPDYE2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:48334. SPDYE2B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Speedy protein E2BPRO_0000399479Add
BLAST

Expressioni

Gene expression databases

BgeeiA6NHP3.
GenevestigatoriA6NHP3.

Organism-specific databases

HPAiHPA044799.
HPA051750.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 36389Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the Speedy/Ringo family.Curated

Phylogenomic databases

GeneTreeiENSGT00420000029723.
HOGENOMiHOG000132466.
HOVERGENiHBG056095.
InParanoidiA6NHP3.
OMAiSILPEHH.
PhylomeDBiA6NHP3.

Family and domain databases

InterProiIPR020984. Cell_cycle_regulatory_Spy1.
[Graphical view]
PfamiPF11357. Spy1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NHP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML
60 70 80 90 100
GPSAPGVDPS PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC
110 120 130 140 150
GLKMKLKQQR VSSILPEHHK DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE
160 170 180 190 200
SEESLEEEPR KVLAPEPEEI WVAEMLCGLK MKLKRRRVSL VLPEHHEAFN
210 220 230 240 250
RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS WQYQRIHFFL
260 270 280 290 300
ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR
310 320 330 340 350
KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR
360 370 380 390 400
KNRSQIVLFQ KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH

LS

Note: No experimental confirmation available.

Length:402
Mass (Da):48,290
Last modified:October 5, 2010 - v2
Checksum:i282148A87EC8A6BD
GO
Isoform 2 (identifier: A6NHP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Note: No experimental confirmation available.

Show »
Length:258
Mass (Da):31,722
Checksum:i20511D2FA8F71DDF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 144144Missing in isoform 2. CuratedVSP_039852Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105052 Genomic DNA. No translation available.
CCDSiCCDS59507.1. [A6NHP3-1]
RefSeqiNP_001159811.1. NM_001166339.1. [A6NHP3-1]
XP_005250150.1. XM_005250093.1. [A6NHP3-1]
UniGeneiHs.433879.

Genome annotation databases

EnsembliENST00000436228; ENSP00000440393; ENSG00000173678. [A6NHP3-1]
ENST00000455020; ENSP00000414338; ENSG00000173678. [A6NHP3-2]
ENST00000507450; ENSP00000424058; ENSG00000173678. [A6NHP3-1]
GeneIDi100310812.
KEGGihsa:100310812.
UCSCiuc011kkx.2. human. [A6NHP3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105052 Genomic DNA. No translation available.
CCDSiCCDS59507.1. [A6NHP3-1]
RefSeqiNP_001159811.1. NM_001166339.1. [A6NHP3-1]
XP_005250150.1. XM_005250093.1. [A6NHP3-1]
UniGeneiHs.433879.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436228; ENSP00000440393; ENSG00000173678. [A6NHP3-1]
ENST00000455020; ENSP00000414338; ENSG00000173678. [A6NHP3-2]
ENST00000507450; ENSP00000424058; ENSG00000173678. [A6NHP3-1]
GeneIDi100310812.
KEGGihsa:100310812.
UCSCiuc011kkx.2. human. [A6NHP3-1]

Organism-specific databases

CTDi100310812.
GeneCardsiGC07P102291.
HGNCiHGNC:48334. SPDYE2B.
HPAiHPA044799.
HPA051750.
neXtProtiNX_A6NHP3.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00420000029723.
HOGENOMiHOG000132466.
HOVERGENiHBG056095.
InParanoidiA6NHP3.
OMAiSILPEHH.
PhylomeDBiA6NHP3.

Miscellaneous databases

GenomeRNAii100310812.

Gene expression databases

BgeeiA6NHP3.
GenevestigatoriA6NHP3.

Family and domain databases

InterProiIPR020984. Cell_cycle_regulatory_Spy1.
[Graphical view]
PfamiPF11357. Spy1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSPE2B_HUMAN
AccessioniPrimary (citable) accession number: A6NHP3
Secondary accession number(s): D6RBN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 5, 2010
Last modified: January 7, 2015
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.