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A6NHP3

- SPE2B_HUMAN

UniProt

A6NHP3 - SPE2B_HUMAN

Protein

Speedy protein E2B

Gene

SPDYE2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Speedy protein E2B
    Gene namesi
    Name:SPDYE2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:48334. SPDYE2B.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Speedy protein E2BPRO_0000399479Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA6NHP3.
    GenevestigatoriA6NHP3.

    Organism-specific databases

    HPAiHPA044799.
    HPA051750.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi275 – 36389Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Speedy/Ringo family.Curated

    Phylogenomic databases

    HOGENOMiHOG000132466.
    HOVERGENiHBG056095.
    InParanoidiA6NHP3.
    OMAiSILPEHH.
    PhylomeDBiA6NHP3.

    Family and domain databases

    InterProiIPR020984. Cell_cycle_regulatory_Spy1.
    [Graphical view]
    PfamiPF11357. Spy1. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6NHP3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML    50
    GPSAPGVDPS PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC 100
    GLKMKLKQQR VSSILPEHHK DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE 150
    SEESLEEEPR KVLAPEPEEI WVAEMLCGLK MKLKRRRVSL VLPEHHEAFN 200
    RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS WQYQRIHFFL 250
    ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR 300
    KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR 350
    KNRSQIVLFQ KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH 400
    LS 402

    Note: No experimental confirmation available.

    Length:402
    Mass (Da):48,290
    Last modified:October 5, 2010 - v2
    Checksum:i282148A87EC8A6BD
    GO
    Isoform 2 (identifier: A6NHP3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-144: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:258
    Mass (Da):31,722
    Checksum:i20511D2FA8F71DDF
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 144144Missing in isoform 2. CuratedVSP_039852Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC105052 Genomic DNA. No translation available.
    CCDSiCCDS59507.1. [A6NHP3-1]
    RefSeqiNP_001159811.1. NM_001166339.1. [A6NHP3-1]
    XP_005250150.1. XM_005250093.1. [A6NHP3-1]
    UniGeneiHs.433879.

    Genome annotation databases

    EnsembliENST00000436228; ENSP00000440393; ENSG00000173678. [A6NHP3-1]
    ENST00000455020; ENSP00000414338; ENSG00000173678. [A6NHP3-2]
    ENST00000507450; ENSP00000424058; ENSG00000173678. [A6NHP3-1]
    GeneIDi100310812.
    KEGGihsa:100310812.
    UCSCiuc011kkx.2. human. [A6NHP3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC105052 Genomic DNA. No translation available.
    CCDSi CCDS59507.1. [A6NHP3-1 ]
    RefSeqi NP_001159811.1. NM_001166339.1. [A6NHP3-1 ]
    XP_005250150.1. XM_005250093.1. [A6NHP3-1 ]
    UniGenei Hs.433879.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000436228 ; ENSP00000440393 ; ENSG00000173678 . [A6NHP3-1 ]
    ENST00000455020 ; ENSP00000414338 ; ENSG00000173678 . [A6NHP3-2 ]
    ENST00000507450 ; ENSP00000424058 ; ENSG00000173678 . [A6NHP3-1 ]
    GeneIDi 100310812.
    KEGGi hsa:100310812.
    UCSCi uc011kkx.2. human. [A6NHP3-1 ]

    Organism-specific databases

    CTDi 100310812.
    GeneCardsi GC07P102291.
    HGNCi HGNC:48334. SPDYE2B.
    HPAi HPA044799.
    HPA051750.
    neXtProti NX_A6NHP3.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000132466.
    HOVERGENi HBG056095.
    InParanoidi A6NHP3.
    OMAi SILPEHH.
    PhylomeDBi A6NHP3.

    Miscellaneous databases

    GenomeRNAii 100310812.

    Gene expression databases

    Bgeei A6NHP3.
    Genevestigatori A6NHP3.

    Family and domain databases

    InterProi IPR020984. Cell_cycle_regulatory_Spy1.
    [Graphical view ]
    Pfami PF11357. Spy1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSPE2B_HUMAN
    AccessioniPrimary (citable) accession number: A6NHP3
    Secondary accession number(s): D6RBN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3