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Protein

Zinc finger protein 860

Gene

ZNF860

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri230 – 25223C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri566 – 58823C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 860
Gene namesi
Name:ZNF860
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:34513. ZNF860.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727773.

Polymorphism and mutation databases

BioMutaiZNF860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Zinc finger protein 860PRO_0000350815Add
BLAST

Proteomic databases

MaxQBiA6NHJ4.
PaxDbiA6NHJ4.
PRIDEiA6NHJ4.

PTM databases

iPTMnetiA6NHJ4.
PhosphoSiteiA6NHJ4.

Expressioni

Gene expression databases

BgeeiENSG00000197385.
CleanExiHS_ZNF860.

Organism-specific databases

HPAiHPA063386.

Interactioni

Protein-protein interaction databases

BioGridi131322. 2 interactions.
STRINGi9606.ENSP00000373274.

Structurei

3D structure databases

ProteinModelPortaliA6NHJ4.
SMRiA6NHJ4. Positions 181-632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9976KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri230 – 25223C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri566 – 58823C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NHJ4.
KOiK09228.
OMAiENYRNLH.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NHJ4.
TreeFamiTF341892.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLREEAAQKR KEKEPGMALP QGHLTFRDVA IEFSLEEWKC LDPTQRALYR
60 70 80 90 100
AMMLENYRNL HSVDISSKCM MKKFSSTAQG NTEVDTGTLE RHESHHIGDF
110 120 130 140 150
CFQKIGKDIH DFEFQWQEDK RNSHEATMTQ IKKLTGSTDR YDRRHPGNKP
160 170 180 190 200
IKDQLGLSFH SHLPELHIFQ TKGKVGNQVE KSINDASSVL TSQRISSRPK
210 220 230 240 250
IHISNNYENN FFHSSLLTLK QEVHIREKSF QCNESGKAFN CSSLLRKHQI
260 270 280 290 300
IYLGGKQYKC DVCGKVFNQK RYLACHHRCH TGEKPYKCNE CGKVFNQQSN
310 320 330 340 350
LASHHRLHTG EKPYKCEECD KVFSRKSNLE RHRRIHTGEK PYKCKVCEKA
360 370 380 390 400
FRRDSHLTQH TRIHTGEKPY KCNECGKAFS GQSTLIHHQA IHGIGKLYKC
410 420 430 440 450
NDCHKVFSNA TTIANHWRIH NEERSYKCNK CGKFFRRRSY LVVHWRTHTG
460 470 480 490 500
EKPYKCNECG KTFHHNSALV IHKAIHTGEK PYKCNECGKT FRHNSALVIH
510 520 530 540 550
KAIHTGEKPY KCNECGKVFN QQATLARHHR LHTGEKPYKC EECDTVFSRK
560 570 580 590 600
SHHETHKRIH TGEKPYKCDD FDEAFSQASS YAKQRRIHMG EKHHKCDDCG
610 620 630
KAFTSHSHRI RHQRIHTGQK SYKCHKRGKV FS
Length:632
Mass (Da):73,757
Last modified:November 25, 2008 - v3
Checksum:i54F37E8AC0386171
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti547 – 5471F → Y in BAG57365 (PubMed:14702039).Curated
Sequence conflicti586 – 5861R → K in BAG57365 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294003 mRNA. Translation: BAG57365.1.
AC108485 Genomic DNA. No translation available.
CCDSiCCDS46784.1.
RefSeqiNP_001131146.2. NM_001137674.2.
UniGeneiHs.585139.

Genome annotation databases

EnsembliENST00000360311; ENSP00000373274; ENSG00000197385.
GeneIDi344787.
KEGGihsa:344787.
UCSCiuc011axg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294003 mRNA. Translation: BAG57365.1.
AC108485 Genomic DNA. No translation available.
CCDSiCCDS46784.1.
RefSeqiNP_001131146.2. NM_001137674.2.
UniGeneiHs.585139.

3D structure databases

ProteinModelPortaliA6NHJ4.
SMRiA6NHJ4. Positions 181-632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131322. 2 interactions.
STRINGi9606.ENSP00000373274.

PTM databases

iPTMnetiA6NHJ4.
PhosphoSiteiA6NHJ4.

Polymorphism and mutation databases

BioMutaiZNF860.

Proteomic databases

MaxQBiA6NHJ4.
PaxDbiA6NHJ4.
PRIDEiA6NHJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360311; ENSP00000373274; ENSG00000197385.
GeneIDi344787.
KEGGihsa:344787.
UCSCiuc011axg.3. human.

Organism-specific databases

CTDi344787.
GeneCardsiZNF860.
HGNCiHGNC:34513. ZNF860.
HPAiHPA063386.
neXtProtiNX_A6NHJ4.
PharmGKBiPA164727773.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NHJ4.
KOiK09228.
OMAiENYRNLH.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NHJ4.
TreeFamiTF341892.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii344787.
PROiA6NHJ4.

Gene expression databases

BgeeiENSG00000197385.
CleanExiHS_ZNF860.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN860_HUMAN
AccessioniPrimary (citable) accession number: A6NHJ4
Secondary accession number(s): B4DFA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.