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Protein

Olfactory receptor 5H14

Gene

OR5H14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33584-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H14
Gene namesi
Name:OR5H14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31286. OR5H14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 56CytoplasmicSequence analysis7
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 143CytoplasmicSequence analysisAdd BLAST24
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 195ExtracellularSequence analysisAdd BLAST31
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 240CytoplasmicSequence analysisAdd BLAST24
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 271ExtracellularSequence analysis10
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 310CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000236032.
PharmGKBiPA134948167.

Polymorphism and mutation databases

BioMutaiOR5H14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119971 – 310Olfactory receptor 5H14Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NHG9.
PRIDEiA6NHG9.

Expressioni

Gene expression databases

CleanExiHS_OR5H14.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000401706.

Structurei

3D structure databases

ProteinModelPortaliA6NHG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NHG9.
KOiK04257.
OMAiHALIHEI.
OrthoDBiEOG091G0C7C.
PhylomeDBiA6NHG9.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW
60 70 80 90 100
KDPHLHIPMY LLLGNLAFVD ALLSSSVTLK MLINFLAKSK MISLSECKIQ
110 120 130 140 150
LFSFAISVTT ECFLLATMAY DRYVAICKPL LYPAIMTNGL CIRLLILSYV
160 170 180 190 200
GGLLHALIHE GFLFRLTFCN SNIIQHFYCD IIPLLKISYT DSSINFLMVF
210 220 230 240 250
IFAGSIQVFT IGTVLISYIF VLYTILKKKS VKGMRKAFST CGAHLLSVSL
260 270 280 290 300
YYGPLAFMYM GSASPQADDQ DMMESLFYTV IVPLLNPMIY SLRNKQVIAS
310
FTKMFKRNDV
Length:310
Mass (Da):35,099
Last modified:July 24, 2007 - v1
Checksum:iE017D9D70AFD2860
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03739364G → R.Corresponds to variant rs4241468dbSNPEnsembl.1
Natural variantiVAR_037394189Y → C.Corresponds to variant rs4857076dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA. No translation available.
BC136984 mRNA. Translation: AAI36985.1.
CCDSiCCDS33798.1.
RefSeqiNP_001005514.1. NM_001005514.1.
UniGeneiHs.554714.
Hs.719887.

Genome annotation databases

EnsembliENST00000437310; ENSP00000401706; ENSG00000236032.
GeneIDi403273.
KEGGihsa:403273.
UCSCiuc003dsg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA. No translation available.
BC136984 mRNA. Translation: AAI36985.1.
CCDSiCCDS33798.1.
RefSeqiNP_001005514.1. NM_001005514.1.
UniGeneiHs.554714.
Hs.719887.

3D structure databases

ProteinModelPortaliA6NHG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000401706.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5H14.

Proteomic databases

PaxDbiA6NHG9.
PRIDEiA6NHG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437310; ENSP00000401706; ENSG00000236032.
GeneIDi403273.
KEGGihsa:403273.
UCSCiuc003dsg.2. human.

Organism-specific databases

CTDi403273.
GeneCardsiOR5H14.
HGNCiHGNC:31286. OR5H14.
neXtProtiNX_A6NHG9.
OpenTargetsiENSG00000236032.
PharmGKBiPA134948167.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NHG9.
KOiK04257.
OMAiHALIHEI.
OrthoDBiEOG091G0C7C.
PhylomeDBiA6NHG9.
TreeFamiTF352737.

Enzyme and pathway databases

BioCyciZFISH:G66-33584-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii403273.
PROiA6NHG9.

Gene expression databases

CleanExiHS_OR5H14.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO5H14_HUMAN
AccessioniPrimary (citable) accession number: A6NHG9
Secondary accession number(s): B9EH15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.