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Protein
Submitted name:

TNF receptor-associated factor 3

Gene

TRAF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 190TRAF-typePROSITE-ProRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor-associated factor 3Imported
Gene namesi
Name:TRAF3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000131323.14
HGNCiHGNC:12033 TRAF3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131323
PharmGKBiPA36710

PTM / Processingi

Proteomic databases

MaxQBiA6NHG8
PeptideAtlasiA6NHG8
PRIDEiA6NHG8

Expressioni

Gene expression databases

BgeeiENSG00000131323
ExpressionAtlasiA6NHG8 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 92RING-typeInterPro annotationAdd BLAST40
Domaini135 – 190TRAF-typeInterPro annotationAdd BLAST56
Domaini390 – 535MATHInterPro annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili291 – 311Sequence analysisAdd BLAST21
Coiled coili322 – 342Sequence analysisAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 190TRAF-typePROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ISDV Eukaryota
ENOG410YQ97 LUCA
GeneTreeiENSGT00550000074359
HOGENOMiHOG000231557
HOVERGENiHBG058222

Family and domain databases

CDDicd03777 MATH_TRAF3, 1 hit
Gene3Di2.60.210.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027128 TRAF3
IPR037304 TRAF3_MATH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR001293 Znf_TRAF
PANTHERiPTHR10131:SF76 PTHR10131:SF76, 2 hits
PfamiView protein in Pfam
PF02176 zf-TRAF, 1 hit
PIRSFiPIRSF015614 TRAF, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 2 hits
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50145 ZF_TRAF, 1 hit

Sequencei

Sequence statusi: Complete.

A6NHG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK
60 70 80 90 100
YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV
110 120 130 140 150
FKDNCCKREI LALQIYCRNE SRGCAEQLML GHLLVHLKND CHFEELPCVR
160 170 180 190 200
PDCKEKVLRK DLRDHVEKAC KYREATCSHC KSQVPMIALQ KHEDTDCPCV
210 220 230 240 250
VVSCPHKCSV QTLLRSEGTN QQIKAHEASS AVQHVNLLKE WSNSLEKKVS
260 270 280 290 300
LLQNESVEKN KSIQSLHNQI CSFEIEIERQ KEMLRNNESK ILHLQRVIDS
310 320 330 340 350
QAEKLKELDK EIRPFRQNWE EADSMKSSVE SLQNRVTELE SVDKSAGQVA
360 370 380 390 400
RNTGLLESQL SRHDQMLSVH DIRLADMDLR FQVLETASYN GVLIWKIRDY
410 420 430 440 450
KRRKQEAVMG KTLSLYSQPF YTGYFGYKMC ARVYLNGDGM GKGTHLSLFF
460 470 480 490 500
VIMRGEYDAL LPWPFKQKVT LMLMDQGSSR RHLGDAFKPD PNSSSFKKPT
510 520 530 540
GEMNIASGCP VFVAQTVLEN GTYIKDDTIF IKVIVDTSDL PDP
Length:543
Mass (Da):61,760
Last modified:July 24, 2007 - v1
Checksum:i83D34832BDFEFC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117209 Genomic DNA No translation available.
AL132801 Genomic DNA No translation available.
RefSeqiNP_663778.1, NM_145726.2
XP_016877108.1, XM_017021619.1
UniGeneiHs.510528

Genome annotation databases

EnsembliENST00000347662; ENSP00000328003; ENSG00000131323
ENST00000351691; ENSP00000332468; ENSG00000131323
GeneIDi7187
UCSCiuc001yme.3 human

Similar proteinsi

Entry informationi

Entry nameiA6NHG8_HUMAN
AccessioniPrimary (citable) accession number: A6NHG8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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