Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

TNF receptor-associated factor 3

Gene

TRAF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor-associated factor 3Imported
Gene namesi
Name:TRAF3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:12033. TRAF3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131323.
PharmGKBiPA36710.

PTM / Processingi

Proteomic databases

MaxQBiA6NHG8.
PeptideAtlasiA6NHG8.
PRIDEiA6NHG8.

Expressioni

Gene expression databases

BgeeiENSG00000131323.
ExpressionAtlasiA6NHG8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376500.

Structurei

3D structure databases

ProteinModelPortaliA6NHG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 92RING-typeInterPro annotationAdd BLAST40
Domaini135 – 190TRAF-typeInterPro annotationAdd BLAST56
Domaini390 – 535MATHInterPro annotationAdd BLAST146

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG410ISDV. Eukaryota.
ENOG410YQ97. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000231557.
HOVERGENiHBG058222.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027128. TRAF3.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF76. PTHR10131:SF76. 1 hit.
PfamiPF02176. zf-TRAF. 1 hit.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK
60 70 80 90 100
YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV
110 120 130 140 150
FKDNCCKREI LALQIYCRNE SRGCAEQLML GHLLVHLKND CHFEELPCVR
160 170 180 190 200
PDCKEKVLRK DLRDHVEKAC KYREATCSHC KSQVPMIALQ KHEDTDCPCV
210 220 230 240 250
VVSCPHKCSV QTLLRSEGTN QQIKAHEASS AVQHVNLLKE WSNSLEKKVS
260 270 280 290 300
LLQNESVEKN KSIQSLHNQI CSFEIEIERQ KEMLRNNESK ILHLQRVIDS
310 320 330 340 350
QAEKLKELDK EIRPFRQNWE EADSMKSSVE SLQNRVTELE SVDKSAGQVA
360 370 380 390 400
RNTGLLESQL SRHDQMLSVH DIRLADMDLR FQVLETASYN GVLIWKIRDY
410 420 430 440 450
KRRKQEAVMG KTLSLYSQPF YTGYFGYKMC ARVYLNGDGM GKGTHLSLFF
460 470 480 490 500
VIMRGEYDAL LPWPFKQKVT LMLMDQGSSR RHLGDAFKPD PNSSSFKKPT
510 520 530 540
GEMNIASGCP VFVAQTVLEN GTYIKDDTIF IKVIVDTSDL PDP
Length:543
Mass (Da):61,760
Last modified:July 24, 2007 - v1
Checksum:i83D34832BDFEFC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117209 Genomic DNA. No translation available.
AL132801 Genomic DNA. No translation available.
RefSeqiNP_663778.1. NM_145726.2.
XP_016877108.1. XM_017021619.1.
UniGeneiHs.510528.

Genome annotation databases

EnsembliENST00000347662; ENSP00000328003; ENSG00000131323.
ENST00000351691; ENSP00000332468; ENSG00000131323.
GeneIDi7187.
UCSCiuc001yme.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117209 Genomic DNA. No translation available.
AL132801 Genomic DNA. No translation available.
RefSeqiNP_663778.1. NM_145726.2.
XP_016877108.1. XM_017021619.1.
UniGeneiHs.510528.

3D structure databases

ProteinModelPortaliA6NHG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376500.

Proteomic databases

MaxQBiA6NHG8.
PeptideAtlasiA6NHG8.
PRIDEiA6NHG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347662; ENSP00000328003; ENSG00000131323.
ENST00000351691; ENSP00000332468; ENSG00000131323.
GeneIDi7187.
UCSCiuc001yme.3. human.

Organism-specific databases

CTDi7187.
HGNCiHGNC:12033. TRAF3.
OpenTargetsiENSG00000131323.
PharmGKBiPA36710.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISDV. Eukaryota.
ENOG410YQ97. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000231557.
HOVERGENiHBG058222.

Miscellaneous databases

ChiTaRSiTRAF3. human.
GenomeRNAii7187.

Gene expression databases

BgeeiENSG00000131323.
ExpressionAtlasiA6NHG8. baseline and differential.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027128. TRAF3.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF76. PTHR10131:SF76. 1 hit.
PfamiPF02176. zf-TRAF. 1 hit.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6NHG8_HUMAN
AccessioniPrimary (citable) accession number: A6NHG8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.