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Protein

D-dopachrome decarboxylase-like protein

Gene

DDTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May have lyase activity.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase-like protein (EC:4.1.1.-)
Alternative name(s):
D-dopachrome tautomerase-like protein
Gene namesi
Name:DDTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:33446. DDTL.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi100037417.
1652.
OpenTargetsiENSG00000099974.
ENSG00000275758.
PharmGKBiPA162383433.

Polymorphism and mutation databases

BioMutaiDDTL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003372421 – 134D-dopachrome decarboxylase-like proteinAdd BLAST134

Proteomic databases

MaxQBiA6NHG4.
PaxDbiA6NHG4.
PRIDEiA6NHG4.

PTM databases

iPTMnetiA6NHG4.
PhosphoSitePlusiA6NHG4.

Expressioni

Gene expression databases

BgeeiENSG00000099974.
CleanExiHS_DDTL.
ExpressionAtlasiA6NHG4. baseline and differential.
GenevisibleiA6NHG4. HS.

Interactioni

Protein-protein interaction databases

BioGridi755774. 4 interactors.
STRINGi9606.ENSP00000215770.

Structurei

3D structure databases

ProteinModelPortaliA6NHG4.
SMRiA6NHG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
InParanoidiA6NHG4.
KOiK10028.
OMAiHQVGKKG.
OrthoDBiEOG091G0ZNJ.
PhylomeDBiA6NHG4.
TreeFamiTF313853.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL
60 70 80 90 100
SGSTEPCAQL SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRFPTVL
110 120 130
STSPAAHGGP RCPGEIIEGK KSCLNEEALF IYFI
Length:134
Mass (Da):14,195
Last modified:July 24, 2007 - v1
Checksum:iB524E7EF14C1A555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296110 mRNA. Translation: BAG58859.1.
DC339950 mRNA. No translation available.
AP000350 Genomic DNA. No translation available.
CCDSiCCDS42988.1.
RefSeqiNP_001077862.1. NM_001084393.1.
UniGeneiHs.744172.

Genome annotation databases

EnsembliENST00000215770; ENSP00000215770; ENSG00000099974.
ENST00000621454; ENSP00000479063; ENSG00000275758.
GeneIDi100037417.
KEGGihsa:100037417.
UCSCiuc002zyy.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296110 mRNA. Translation: BAG58859.1.
DC339950 mRNA. No translation available.
AP000350 Genomic DNA. No translation available.
CCDSiCCDS42988.1.
RefSeqiNP_001077862.1. NM_001084393.1.
UniGeneiHs.744172.

3D structure databases

ProteinModelPortaliA6NHG4.
SMRiA6NHG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi755774. 4 interactors.
STRINGi9606.ENSP00000215770.

PTM databases

iPTMnetiA6NHG4.
PhosphoSitePlusiA6NHG4.

Polymorphism and mutation databases

BioMutaiDDTL.

Proteomic databases

MaxQBiA6NHG4.
PaxDbiA6NHG4.
PRIDEiA6NHG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215770; ENSP00000215770; ENSG00000099974.
ENST00000621454; ENSP00000479063; ENSG00000275758.
GeneIDi100037417.
KEGGihsa:100037417.
UCSCiuc002zyy.5. human.

Organism-specific databases

CTDi100037417.
DisGeNETi100037417.
1652.
GeneCardsiDDTL.
HGNCiHGNC:33446. DDTL.
neXtProtiNX_A6NHG4.
OpenTargetsiENSG00000099974.
ENSG00000275758.
PharmGKBiPA162383433.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
InParanoidiA6NHG4.
KOiK10028.
OMAiHQVGKKG.
OrthoDBiEOG091G0ZNJ.
PhylomeDBiA6NHG4.
TreeFamiTF313853.

Miscellaneous databases

GenomeRNAii100037417.
PROiA6NHG4.

Gene expression databases

BgeeiENSG00000099974.
CleanExiHS_DDTL.
ExpressionAtlasiA6NHG4. baseline and differential.
GenevisibleiA6NHG4. HS.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDTL_HUMAN
AccessioniPrimary (citable) accession number: A6NHG4
Secondary accession number(s): B4DJJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.