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Protein

D-dopachrome decarboxylase-like protein

Gene

DDTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have lyase activity.Curated

GO - Molecular functioni

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase-like protein (EC:4.1.1.-)
Alternative name(s):
D-dopachrome tautomerase-like protein
Gene namesi
Name:DDTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099974.7
HGNCiHGNC:33446 DDTL
neXtProtiNX_A6NHG4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi100037417
OpenTargetsiENSG00000099974
PharmGKBiPA162383433

Polymorphism and mutation databases

BioMutaiDDTL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003372421 – 134D-dopachrome decarboxylase-like proteinAdd BLAST134

Proteomic databases

EPDiA6NHG4
MaxQBiA6NHG4
PaxDbiA6NHG4
PRIDEiA6NHG4
ProteomicsDBi1195

PTM databases

iPTMnetiA6NHG4
PhosphoSitePlusiA6NHG4

Expressioni

Gene expression databases

BgeeiENSG00000099974
CleanExiHS_DDTL
ExpressionAtlasiA6NHG4 baseline and differential
GenevisibleiA6NHG4 HS

Interactioni

Protein-protein interaction databases

BioGridi755774, 4 interactors
STRINGi9606.ENSP00000215770

Structurei

3D structure databases

ProteinModelPortaliA6NHG4
SMRiA6NHG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759 Eukaryota
ENOG41122MF LUCA
GeneTreeiENSGT00910000144293
HOGENOMiHOG000112325
InParanoidiA6NHG4
KOiK10028
OMAiHQVGKKG
OrthoDBiEOG091G0ZNJ
PhylomeDBiA6NHG4
TreeFamiTF313853

Family and domain databases

Gene3Di3.30.429.10, 1 hit
InterProiView protein in InterPro
IPR001398 Macrophage_inhib_fac
IPR019829 Macrophage_inhib_fac_CS
IPR014347 Tautomerase/MIF_sf
PANTHERiPTHR11954 PTHR11954, 1 hit
PfamiView protein in Pfam
PF01187 MIF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004816 Macrophage_inhib_fac, 1 hit
SUPFAMiSSF55331 SSF55331, 1 hit
PROSITEiView protein in PROSITE
PS01158 MIF, 1 hit

Sequencei

Sequence statusi: Complete.

A6NHG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL
60 70 80 90 100
SGSTEPCAQL SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRFPTVL
110 120 130
STSPAAHGGP RCPGEIIEGK KSCLNEEALF IYFI
Length:134
Mass (Da):14,195
Last modified:July 24, 2007 - v1
Checksum:iB524E7EF14C1A555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296110 mRNA Translation: BAG58859.1
DC339950 mRNA No translation available.
AP000350 Genomic DNA No translation available.
CCDSiCCDS42988.1
RefSeqiNP_001077862.1, NM_001084393.1
UniGeneiHs.744172

Genome annotation databases

EnsembliENST00000215770; ENSP00000215770; ENSG00000099974
ENST00000621454; ENSP00000479063; ENSG00000275758
GeneIDi100037417
KEGGihsa:100037417
UCSCiuc002zyy.5 human

Similar proteinsi

Entry informationi

Entry nameiDDTL_HUMAN
AccessioniPrimary (citable) accession number: A6NHG4
Secondary accession number(s): B4DJJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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