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Protein

Olfactory receptor 4C46

Gene

OR4C46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C46
Gene namesi
Name:OR4C46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000185926.1
HGNCiHGNC:31271 OR4C46
neXtProtiNX_A6NHA9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 46CytoplasmicSequence analysis2
Transmembranei47 – 67Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini68 – 103ExtracellularSequence analysisAdd BLAST36
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 141CytoplasmicSequence analysisAdd BLAST17
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 202ExtracellularSequence analysisAdd BLAST40
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 236CytoplasmicSequence analysisAdd BLAST13
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 266ExtracellularSequence analysis9
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 309CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi119749
OpenTargetsiENSG00000185926
PharmGKBiPA134910149

Polymorphism and mutation databases

BioMutaiOR4C46

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104561 – 309Olfactory receptor 4C46Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NHA9
PRIDEiA6NHA9

PTM databases

iPTMnetiA6NHA9
PhosphoSitePlusiA6NHA9

Expressioni

Gene expression databases

CleanExiHS_OR4C46

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329056

Structurei

3D structure databases

ProteinModelPortaliA6NHA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKHV Eukaryota
ENOG4111834 LUCA
GeneTreeiENSGT00910000144032
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiA6NHA9
KOiK04257
OMAiPCVFVYM
OrthoDBiEOG091G0CY9
PhylomeDBiA6NHA9
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NHA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENRNNMTEF VLLGLTENPK MQKIIFVVFF VIYIITVVGY VLIVVTITAS
60 70 80 90 100
PSLGSPMYLS LAYLSFIDAC YSSVNTPNLI THSLYGKKAI LFNGCMTQVF
110 120 130 140 150
GEHFFGGAEG ILLTVMAYDH YVAICKPLHY MTIMNQCVCA LLMGVVWMGG
160 170 180 190 200
FLHATIQILF IFQLPFCGPN VIDHFMCDLN PLLNLACTDT HMLELFIAAN
210 220 230 240 250
SGFICLLNFA LLLVSYVVIL CSLRTHSLEA RHKALSTCVS HITVVILFFV
260 270 280 290 300
PCIFVYMRPA ATLPIDKAVA IFYTMITPML NPLIYTLKNA QMKNAIRKLC

SRKDISGDK
Length:309
Mass (Da):34,533
Last modified:July 24, 2007 - v1
Checksum:i0A1EF3DBE5FBFAED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037045240S → F. Corresponds to variant dbSNP:rs11246607Ensembl.1
Natural variantiVAR_037046252C → Y. Corresponds to variant dbSNP:rs11246608Ensembl.1
Natural variantiVAR_037047288K → R. Corresponds to variant dbSNP:rs11246609Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126345 Genomic DNA No translation available.
CCDSiCCDS73288.1
RefSeqiNP_001004703.1, NM_001004703.1
UniGeneiHs.553564

Genome annotation databases

EnsembliENST00000328188; ENSP00000329056; ENSG00000185926
GeneIDi119749
KEGGihsa:119749
UCSCiuc010ric.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO4C46_HUMAN
AccessioniPrimary (citable) accession number: A6NHA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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