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Protein

Olfactory receptor 4C46

Gene

OR4C46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33692-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C46
Gene namesi
Name:OR4C46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:31271. OR4C46.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 46CytoplasmicSequence analysis2
Transmembranei47 – 67Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini68 – 103ExtracellularSequence analysisAdd BLAST36
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 141CytoplasmicSequence analysisAdd BLAST17
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 202ExtracellularSequence analysisAdd BLAST40
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 236CytoplasmicSequence analysisAdd BLAST13
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 266ExtracellularSequence analysis9
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 309CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi119749.
OpenTargetsiENSG00000185926.
PharmGKBiPA134910149.

Polymorphism and mutation databases

BioMutaiOR4C46.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104561 – 309Olfactory receptor 4C46Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NHA9.
PRIDEiA6NHA9.

PTM databases

iPTMnetiA6NHA9.
PhosphoSitePlusiA6NHA9.

Expressioni

Gene expression databases

CleanExiHS_OR4C46.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329056.

Structurei

3D structure databases

ProteinModelPortaliA6NHA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKHV. Eukaryota.
ENOG4111834. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiA6NHA9.
KOiK04257.
OMAiDTHMLEL.
OrthoDBiEOG091G0CY9.
PhylomeDBiA6NHA9.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENRNNMTEF VLLGLTENPK MQKIIFVVFF VIYIITVVGY VLIVVTITAS
60 70 80 90 100
PSLGSPMYLS LAYLSFIDAC YSSVNTPNLI THSLYGKKAI LFNGCMTQVF
110 120 130 140 150
GEHFFGGAEG ILLTVMAYDH YVAICKPLHY MTIMNQCVCA LLMGVVWMGG
160 170 180 190 200
FLHATIQILF IFQLPFCGPN VIDHFMCDLN PLLNLACTDT HMLELFIAAN
210 220 230 240 250
SGFICLLNFA LLLVSYVVIL CSLRTHSLEA RHKALSTCVS HITVVILFFV
260 270 280 290 300
PCIFVYMRPA ATLPIDKAVA IFYTMITPML NPLIYTLKNA QMKNAIRKLC

SRKDISGDK
Length:309
Mass (Da):34,533
Last modified:July 24, 2007 - v1
Checksum:i0A1EF3DBE5FBFAED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037045240S → F.Corresponds to variant rs11246607dbSNPEnsembl.1
Natural variantiVAR_037046252C → Y.Corresponds to variant rs11246608dbSNPEnsembl.1
Natural variantiVAR_037047288K → R.Corresponds to variant rs11246609dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126345 Genomic DNA. No translation available.
CCDSiCCDS73288.1.
RefSeqiNP_001004703.1. NM_001004703.1.
UniGeneiHs.553564.

Genome annotation databases

EnsembliENST00000328188; ENSP00000329056; ENSG00000185926.
GeneIDi119749.
KEGGihsa:119749.
UCSCiuc010ric.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126345 Genomic DNA. No translation available.
CCDSiCCDS73288.1.
RefSeqiNP_001004703.1. NM_001004703.1.
UniGeneiHs.553564.

3D structure databases

ProteinModelPortaliA6NHA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329056.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NHA9.
PhosphoSitePlusiA6NHA9.

Polymorphism and mutation databases

BioMutaiOR4C46.

Proteomic databases

PaxDbiA6NHA9.
PRIDEiA6NHA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328188; ENSP00000329056; ENSG00000185926.
GeneIDi119749.
KEGGihsa:119749.
UCSCiuc010ric.2. human.

Organism-specific databases

CTDi119749.
DisGeNETi119749.
GeneCardsiOR4C46.
HGNCiHGNC:31271. OR4C46.
neXtProtiNX_A6NHA9.
OpenTargetsiENSG00000185926.
PharmGKBiPA134910149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKHV. Eukaryota.
ENOG4111834. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiA6NHA9.
KOiK04257.
OMAiDTHMLEL.
OrthoDBiEOG091G0CY9.
PhylomeDBiA6NHA9.
TreeFamiTF352732.

Enzyme and pathway databases

BioCyciZFISH:G66-33692-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii119749.
PROiA6NHA9.

Gene expression databases

CleanExiHS_OR4C46.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO4C46_HUMAN
AccessioniPrimary (citable) accession number: A6NHA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.