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Protein

Olfactory receptor 4C46

Gene

OR4C46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C46
Gene namesi
Name:OR4C46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:31271. OR4C46.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 462CytoplasmicSequence analysis
Transmembranei47 – 6721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini68 – 10336ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14117CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 20240ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini224 – 23613CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 2669ExtracellularSequence analysis
Transmembranei267 – 28721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini288 – 30922CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910149.

Polymorphism and mutation databases

BioMutaiOR4C46.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 4C46PRO_0000310456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NHA9.
PRIDEiA6NHA9.

PTM databases

iPTMnetiA6NHA9.
PhosphoSiteiA6NHA9.

Expressioni

Gene expression databases

CleanExiHS_OR4C46.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329056.

Structurei

3D structure databases

ProteinModelPortaliA6NHA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKHV. Eukaryota.
ENOG4111834. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiA6NHA9.
KOiK04257.
OMAiDTHMLEL.
OrthoDBiEOG091G0CY9.
PhylomeDBiA6NHA9.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NHA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENRNNMTEF VLLGLTENPK MQKIIFVVFF VIYIITVVGY VLIVVTITAS
60 70 80 90 100
PSLGSPMYLS LAYLSFIDAC YSSVNTPNLI THSLYGKKAI LFNGCMTQVF
110 120 130 140 150
GEHFFGGAEG ILLTVMAYDH YVAICKPLHY MTIMNQCVCA LLMGVVWMGG
160 170 180 190 200
FLHATIQILF IFQLPFCGPN VIDHFMCDLN PLLNLACTDT HMLELFIAAN
210 220 230 240 250
SGFICLLNFA LLLVSYVVIL CSLRTHSLEA RHKALSTCVS HITVVILFFV
260 270 280 290 300
PCIFVYMRPA ATLPIDKAVA IFYTMITPML NPLIYTLKNA QMKNAIRKLC

SRKDISGDK
Length:309
Mass (Da):34,533
Last modified:July 24, 2007 - v1
Checksum:i0A1EF3DBE5FBFAED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti240 – 2401S → F.
Corresponds to variant rs11246607 [ dbSNP | Ensembl ].
VAR_037045
Natural varianti252 – 2521C → Y.
Corresponds to variant rs11246608 [ dbSNP | Ensembl ].
VAR_037046
Natural varianti288 – 2881K → R.
Corresponds to variant rs11246609 [ dbSNP | Ensembl ].
VAR_037047

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126345 Genomic DNA. No translation available.
CCDSiCCDS73288.1.
RefSeqiNP_001004703.1. NM_001004703.1.
UniGeneiHs.553564.

Genome annotation databases

EnsembliENST00000328188; ENSP00000329056; ENSG00000185926.
GeneIDi119749.
KEGGihsa:119749.
UCSCiuc010ric.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126345 Genomic DNA. No translation available.
CCDSiCCDS73288.1.
RefSeqiNP_001004703.1. NM_001004703.1.
UniGeneiHs.553564.

3D structure databases

ProteinModelPortaliA6NHA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329056.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NHA9.
PhosphoSiteiA6NHA9.

Polymorphism and mutation databases

BioMutaiOR4C46.

Proteomic databases

PaxDbiA6NHA9.
PRIDEiA6NHA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328188; ENSP00000329056; ENSG00000185926.
GeneIDi119749.
KEGGihsa:119749.
UCSCiuc010ric.2. human.

Organism-specific databases

CTDi119749.
GeneCardsiOR4C46.
HGNCiHGNC:31271. OR4C46.
neXtProtiNX_A6NHA9.
PharmGKBiPA134910149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKHV. Eukaryota.
ENOG4111834. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiA6NHA9.
KOiK04257.
OMAiDTHMLEL.
OrthoDBiEOG091G0CY9.
PhylomeDBiA6NHA9.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii119749.
PROiA6NHA9.

Gene expression databases

CleanExiHS_OR4C46.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO4C46_HUMAN
AccessioniPrimary (citable) accession number: A6NHA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.