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Protein

Putative ADP-ribosylation factor-like protein 5C

Gene

ARL5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds and exchanges GTP and GDP.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi125 – 1284GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ADP-ribosylation factor-like protein 5C
Alternative name(s):
ADP-ribosylation factor-like protein 12
Gene namesi
Name:ARL5C
Synonyms:ARL12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:31111. ARL5C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134964408.

Polymorphism and mutation databases

BioMutaiARL5C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 179178Putative ADP-ribosylation factor-like protein 5CPRO_0000332303Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiA6NH57.
PRIDEiA6NH57.

PTM databases

PhosphoSiteiA6NH57.

Expressioni

Gene expression databases

BgeeiA6NH57.
CleanExiHS_ARL5C.
ExpressionAtlasiA6NH57. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000269586.

Structurei

3D structure databases

ProteinModelPortaliA6NH57.
SMRiA6NH57. Positions 6-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiA6NH57.
KOiK07960.
OMAiALRSTWN.
OrthoDBiEOG7VHSZV.
PhylomeDBiA6NH57.
TreeFamiTF105465.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NH57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQLIAKLMS IFGNQEHTVI IVGLDNEGKT TILYRFLTNE VVHMCPTIGS
60 70 80 90 100
NVEEIILPKT HFFMWDIVRP EALSFIWNTY YSNTEFIILV IDSTDRDRLL
110 120 130 140 150
TTREELYKML AHEALQDASV LIFANKQDVK DSMRMVEISH FLTLSTIKDH
160 170
SWHIQGCCAL TREGLPARLQ WMESQAAAN
Length:179
Mass (Da):20,591
Last modified:July 22, 2008 - v4
Checksum:i2425EC4C595BEAED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004408 Genomic DNA. No translation available.
CCDSiCCDS45664.1.
RefSeqiNP_001137440.1. NM_001143968.1.
UniGeneiHs.568007.

Genome annotation databases

EnsembliENST00000269586; ENSP00000269586; ENSG00000141748.
GeneIDi390790.
KEGGihsa:390790.
UCSCiuc010wea.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004408 Genomic DNA. No translation available.
CCDSiCCDS45664.1.
RefSeqiNP_001137440.1. NM_001143968.1.
UniGeneiHs.568007.

3D structure databases

ProteinModelPortaliA6NH57.
SMRiA6NH57. Positions 6-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269586.

PTM databases

PhosphoSiteiA6NH57.

Polymorphism and mutation databases

BioMutaiARL5C.

Proteomic databases

PaxDbiA6NH57.
PRIDEiA6NH57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269586; ENSP00000269586; ENSG00000141748.
GeneIDi390790.
KEGGihsa:390790.
UCSCiuc010wea.3. human.

Organism-specific databases

CTDi390790.
GeneCardsiARL5C.
HGNCiHGNC:31111. ARL5C.
neXtProtiNX_A6NH57.
PharmGKBiPA134964408.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiA6NH57.
KOiK07960.
OMAiALRSTWN.
OrthoDBiEOG7VHSZV.
PhylomeDBiA6NH57.
TreeFamiTF105465.

Miscellaneous databases

GenomeRNAii390790.
NextBioi104035.
PROiA6NH57.

Gene expression databases

BgeeiA6NH57.
CleanExiHS_ARL5C.
ExpressionAtlasiA6NH57. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiARL5C_HUMAN
AccessioniPrimary (citable) accession number: A6NH57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 22, 2008
Last modified: May 11, 2016
This is version 72 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.