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Protein

Serine incorporator 4

Gene

SERINC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 4
Gene namesi
Name:SERINC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:32237. SERINC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35720HelicalSequence analysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence analysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670936.

Polymorphism and mutation databases

BioMutaiSERINC4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Serine incorporator 4PRO_0000333871Add
BLAST

Proteomic databases

PaxDbiA6NH21.
PRIDEiA6NH21.

PTM databases

PhosphoSiteiA6NH21.

Expressioni

Gene expression databases

BgeeiA6NH21.
CleanExiHS_SERINC4.
ExpressionAtlasiA6NH21. baseline and differential.

Organism-specific databases

HPAiHPA018526.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319796.

Structurei

3D structure databases

ProteinModelPortaliA6NH21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 4715Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiA6NH21.
OMAiSWNKNWQ.
PhylomeDBiA6NH21.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029563. Serinc4.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF5. PTHR10383:SF5. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NH21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGAKAGPSP GTSLGLAQQH SGGSSVLVKS PFCQVCCCGP APCASCCHSR
60 70 80 90 100
WPSLTASTCS RLFYILLHVG ASAICCLLLS RTVVERVWGK THRIQMPSGL
110 120 130 140 150
CAHLFGLSDC PVLSGSGAVY RVCAGTATFH LLQAVLLVHL HSPTSPRAQL
160 170 180 190 200
HNSFWLLKLL FLLGLCAIAF CIPDEHLFPA WHYIGICGGF AFILLQLVLI
210 220 230 240 250
TAFAHSWNKN WQTGAAQDCS WFLAVLLATL GFYSMAGVGA VLLFHYYTHP
260 270 280 290 300
AGCLLNKMLL SLHLCFCGLI SFLSIAPCIR LKQPRSGLLQ ASVISCYIMY
310 320 330 340 350
LTFSALSSRP PERVILQGQN HTLCLPGLSK MEPQTPDISL AMLSASIMYA
360 370 380 390 400
CVLFACNEAS YLAEVFGPLW IVKVYSYEFQ KPSLCFCCPE TVEADKGQRG
410 420 430 440 450
GAARPADQET PPAPPVQVQH LSYNYSAFHF VFFLASLYVM VTLTNWFSYE
460 470 480 490 500
GAELEKTFIK GSWATFWVKV ASCWACVLLY LGLLLAPLCW PPTQKPQPLI
510
LRRRRHRIIS PDNKYPPV
Length:518
Mass (Da):56,870
Last modified:July 24, 2007 - v1
Checksum:i93A6224C102565AE
GO
Isoform 2 (identifier: A6NH21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.
     245-282: HYYTHPAGCL...LSIAPCIRLK → MSISSQHGIT...LLPIPGTRTE

Show »
Length:274
Mass (Da):30,680
Checksum:iC165159D5687505F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 244244Missing in isoform 2. 2 PublicationsVSP_033584Add
BLAST
Alternative sequencei245 – 28238HYYTH…CIRLK → MSISSQHGITLASVEALHSS YCSWCLLQLLPIPGTRTE in isoform 2. 2 PublicationsVSP_033585Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ103711 mRNA. Translation: AAZ80298.1.
AC018512 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77244.1.
CH471082 Genomic DNA. Translation: EAW77245.1.
BC136669 mRNA. Translation: AAI36670.1.
CCDSiCCDS58360.1. [A6NH21-1]
RefSeqiNP_001244960.1. NM_001258031.1. [A6NH21-1]
NP_001244961.1. NM_001258032.1. [A6NH21-2]
UniGeneiHs.424126.
Hs.604985.

Genome annotation databases

EnsembliENST00000319327; ENSP00000319796; ENSG00000184716. [A6NH21-1]
GeneIDi619189.
KEGGihsa:619189.
UCSCiuc031qrp.2. human. [A6NH21-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ103711 mRNA. Translation: AAZ80298.1.
AC018512 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77244.1.
CH471082 Genomic DNA. Translation: EAW77245.1.
BC136669 mRNA. Translation: AAI36670.1.
CCDSiCCDS58360.1. [A6NH21-1]
RefSeqiNP_001244960.1. NM_001258031.1. [A6NH21-1]
NP_001244961.1. NM_001258032.1. [A6NH21-2]
UniGeneiHs.424126.
Hs.604985.

3D structure databases

ProteinModelPortaliA6NH21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319796.

PTM databases

PhosphoSiteiA6NH21.

Polymorphism and mutation databases

BioMutaiSERINC4.

Proteomic databases

PaxDbiA6NH21.
PRIDEiA6NH21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319327; ENSP00000319796; ENSG00000184716. [A6NH21-1]
GeneIDi619189.
KEGGihsa:619189.
UCSCiuc031qrp.2. human. [A6NH21-1]

Organism-specific databases

CTDi619189.
GeneCardsiSERINC4.
H-InvDBHIX0012191.
HIX0079719.
HGNCiHGNC:32237. SERINC4.
HPAiHPA018526.
MIMi614550. gene.
neXtProtiNX_A6NH21.
PharmGKBiPA142670936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiA6NH21.
OMAiSWNKNWQ.
PhylomeDBiA6NH21.
TreeFamiTF312881.

Miscellaneous databases

GenomeRNAii619189.
NextBioi112866.
PROiA6NH21.
SOURCEiSearch...

Gene expression databases

BgeeiA6NH21.
CleanExiHS_SERINC4.
ExpressionAtlasiA6NH21. baseline and differential.

Family and domain databases

InterProiIPR029563. Serinc4.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF5. PTHR10383:SF5. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis."
    Inuzuka M., Hayakawa M., Ingi T.
    J. Biol. Chem. 280:35776-35783(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
    Tissue: Lung.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiSERC4_HUMAN
AccessioniPrimary (citable) accession number: A6NH21
Secondary accession number(s): B2RN41, Q3YL75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.