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Protein

Serine incorporator 4

Gene

SERINC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-977347 Serine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 4
Gene namesi
Name:SERINC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000184716.13
HGNCiHGNC:32237 SERINC4
MIMi614550 gene
neXtProtiNX_A6NH21

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei338 – 357HelicalSequence analysisAdd BLAST20
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670936

Polymorphism and mutation databases

BioMutaiSERINC4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338711 – 518Serine incorporator 4Add BLAST518

Proteomic databases

PaxDbiA6NH21
PRIDEiA6NH21

PTM databases

iPTMnetiA6NH21
PhosphoSitePlusiA6NH21

Expressioni

Gene expression databases

BgeeiENSG00000184716
CleanExiHS_SERINC4
ExpressionAtlasiA6NH21 baseline and differential

Organism-specific databases

HPAiHPA018526

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319796

Structurei

3D structure databases

ProteinModelPortaliA6NH21
SMRiA6NH21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 47Cys-richAdd BLAST15

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiA6NH21
OMAiSWNKNWQ
OrthoDBiEOG091G06BW
PhylomeDBiA6NH21
TreeFamiTF312881

Family and domain databases

InterProiView protein in InterPro
IPR029563 Serinc4
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF5 PTHR10383:SF5, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NH21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGAKAGPSP GTSLGLAQQH SGGSSVLVKS PFCQVCCCGP APCASCCHSR
60 70 80 90 100
WPSLTASTCS RLFYILLHVG ASAICCLLLS RTVVERVWGK THRIQMPSGL
110 120 130 140 150
CAHLFGLSDC PVLSGSGAVY RVCAGTATFH LLQAVLLVHL HSPTSPRAQL
160 170 180 190 200
HNSFWLLKLL FLLGLCAIAF CIPDEHLFPA WHYIGICGGF AFILLQLVLI
210 220 230 240 250
TAFAHSWNKN WQTGAAQDCS WFLAVLLATL GFYSMAGVGA VLLFHYYTHP
260 270 280 290 300
AGCLLNKMLL SLHLCFCGLI SFLSIAPCIR LKQPRSGLLQ ASVISCYIMY
310 320 330 340 350
LTFSALSSRP PERVILQGQN HTLCLPGLSK MEPQTPDISL AMLSASIMYA
360 370 380 390 400
CVLFACNEAS YLAEVFGPLW IVKVYSYEFQ KPSLCFCCPE TVEADKGQRG
410 420 430 440 450
GAARPADQET PPAPPVQVQH LSYNYSAFHF VFFLASLYVM VTLTNWFSYE
460 470 480 490 500
GAELEKTFIK GSWATFWVKV ASCWACVLLY LGLLLAPLCW PPTQKPQPLI
510
LRRRRHRIIS PDNKYPPV
Length:518
Mass (Da):56,870
Last modified:July 24, 2007 - v1
Checksum:i93A6224C102565AE
GO
Isoform 2 (identifier: A6NH21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.
     245-282: HYYTHPAGCL...LSIAPCIRLK → MSISSQHGIT...LLPIPGTRTE

Show »
Length:274
Mass (Da):30,680
Checksum:iC165159D5687505F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335841 – 244Missing in isoform 2. 2 PublicationsAdd BLAST244
Alternative sequenceiVSP_033585245 – 282HYYTH…CIRLK → MSISSQHGITLASVEALHSS YCSWCLLQLLPIPGTRTE in isoform 2. 2 PublicationsAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ103711 mRNA Translation: AAZ80298.1
AC018512 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77244.1
CH471082 Genomic DNA Translation: EAW77245.1
BC136669 mRNA Translation: AAI36670.1
CCDSiCCDS58360.1 [A6NH21-1]
RefSeqiNP_001244960.1, NM_001258031.1 [A6NH21-1]
NP_001244961.1, NM_001258032.1 [A6NH21-2]
UniGeneiHs.424126
Hs.604985

Genome annotation databases

EnsembliENST00000319327; ENSP00000319796; ENSG00000184716 [A6NH21-1]
GeneIDi619189
KEGGihsa:619189
UCSCiuc031qrp.2 human [A6NH21-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSERC4_HUMAN
AccessioniPrimary (citable) accession number: A6NH21
Secondary accession number(s): B2RN41, Q3YL75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health