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Protein

Olfactory receptor 2T8

Gene

OR2T8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T8
Gene namesi
Name:OR2T8
Synonyms:OR2T8P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15020. OR2T8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9620ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 14326CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini165 – 20137ExtracellularSequence analysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini223 – 23412CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini256 – 26914ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 31222CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32208.

Polymorphism and mutation databases

BioMutaiOR2T8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2T8PRO_0000311914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NH00.
PRIDEiA6NH00.

PTM databases

iPTMnetiA6NH00.
PhosphoSiteiA6NH00.

Expressioni

Gene expression databases

CleanExiHS_OR2T8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326225.

Structurei

3D structure databases

ProteinModelPortaliA6NH00.
SMRiA6NH00. Positions 24-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEQD. Eukaryota.
ENOG4111EHF. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NH00.
KOiK04257.
OMAiRCVALSH.
OrthoDBiEOG091G0DUZ.
PhylomeDBiA6NH00.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NH00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGSYTSYF ILLGLFNHTR AHQVLFMMVL SIVLTSLFGN SLMILLIHWD
60 70 80 90 100
HRLHTPMYFL LSQLSLMDVM LVSTTVPKMA ADYLTGSKAI SRAGCGAQIF
110 120 130 140 150
FLPTLGGGEC FLLAAMAYDR YAAVCHPLRY PTLMSWQLCL RMNLSCWLLG
160 170 180 190 200
AADGLLQAVA TLSFPYCGAH EIDHFFCETP VLVRLACADT SVFENAMYIC
210 220 230 240 250
CVLMLLVPFS LILSSYGLIL AAVLHMRSTE ARKKAFATCS SHVAVVGLFY
260 270 280 290 300
GAAIFTYMRP KSHRSTNHDK VVSAFYTMFT PLLNPLIYSV KNSEVKGALT
310
RCMGRCVALS RE
Length:312
Mass (Da):34,659
Last modified:July 24, 2007 - v1
Checksum:i9708C7ABB1216EFD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391G → S.
Corresponds to variant rs11204563 [ dbSNP | Ensembl ].
VAR_037342
Natural varianti49 – 491W → R.
Corresponds to variant rs11204564 [ dbSNP | Ensembl ].
VAR_037343
Natural varianti69 – 691V → M.
Corresponds to variant rs28575687 [ dbSNP | Ensembl ].
VAR_062028
Natural varianti179 – 1791T → A.
Corresponds to variant rs4584426 [ dbSNP | Ensembl ].
VAR_037344
Natural varianti197 – 1971M → R.
Corresponds to variant rs34508376 [ dbSNP | Ensembl ].
VAR_037345
Natural varianti221 – 2211A → S.
Corresponds to variant rs4362017 [ dbSNP | Ensembl ].
VAR_037346
Natural varianti305 – 3051R → W.
Corresponds to variant rs6695357 [ dbSNP | Ensembl ].
VAR_037347
Natural varianti311 – 3111R → H.
Corresponds to variant rs58882030 [ dbSNP | Ensembl ].
VAR_062029

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099571 Genomic DNA. No translation available.
CCDSiCCDS31100.1.
RefSeqiNP_001005522.1. NM_001005522.1.
XP_011542480.1. XM_011544178.2.
UniGeneiHs.521114.

Genome annotation databases

EnsembliENST00000319968; ENSP00000326225; ENSG00000177462.
GeneIDi343172.
KEGGihsa:343172.
UCSCiuc010pzc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099571 Genomic DNA. No translation available.
CCDSiCCDS31100.1.
RefSeqiNP_001005522.1. NM_001005522.1.
XP_011542480.1. XM_011544178.2.
UniGeneiHs.521114.

3D structure databases

ProteinModelPortaliA6NH00.
SMRiA6NH00. Positions 24-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326225.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NH00.
PhosphoSiteiA6NH00.

Polymorphism and mutation databases

BioMutaiOR2T8.

Proteomic databases

PaxDbiA6NH00.
PRIDEiA6NH00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319968; ENSP00000326225; ENSG00000177462.
GeneIDi343172.
KEGGihsa:343172.
UCSCiuc010pzc.2. human.

Organism-specific databases

CTDi343172.
GeneCardsiOR2T8.
HGNCiHGNC:15020. OR2T8.
neXtProtiNX_A6NH00.
PharmGKBiPA32208.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEQD. Eukaryota.
ENOG4111EHF. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NH00.
KOiK04257.
OMAiRCVALSH.
OrthoDBiEOG091G0DUZ.
PhylomeDBiA6NH00.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii343172.
PROiA6NH00.

Gene expression databases

CleanExiHS_OR2T8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2T8_HUMAN
AccessioniPrimary (citable) accession number: A6NH00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.