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Protein

Protein FRG2-like-2

Gene

FRG2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FRG2-like-2
Alternative name(s):
FSHD region gene 2 protein family member C
HSA3-FRG2
Gene namesi
Name:FRG2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:33626. FRG2C.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Protein FRG2-like-2PRO_0000300692Add
BLAST

Proteomic databases

PaxDbiA6NGY1.
PRIDEiA6NGY1.

PTM databases

PhosphoSiteiA6NGY1.

Expressioni

Gene expression databases

BgeeiA6NGY1.
ExpressionAtlasiA6NGY1. baseline and differential.
GenevestigatoriA6NGY1.

Organism-specific databases

HPAiHPA039264.
HPA047769.

Structurei

3D structure databases

ProteinModelPortaliA6NGY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FRG2 family.Curated

Phylogenomic databases

eggNOGiNOG86920.
GeneTreeiENSGT00530000064266.
HOGENOMiHOG000112644.
HOVERGENiHBG106627.
InParanoidiA6NGY1.
OMAiISSKDIC.
PhylomeDBiA6NGY1.
TreeFamiTF342559.

Family and domain databases

InterProiIPR026245. FRG2.
[Graphical view]
PANTHERiPTHR31883. PTHR31883. 1 hit.
PfamiPF15315. FRG2. 1 hit.
[Graphical view]
PRINTSiPR02074. PROTEINFRG2.

Sequencei

Sequence statusi: Complete.

A6NGY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGNEDPDL HCSSIQCSTD QPPFQQISFT EKGSDEKKPF KGKGKTAFSH
60 70 80 90 100
SSEKHTQRQA GSDPNPNKEN SEETKLKAGN STAGSEPESS SYQENCRKRK
110 120 130 140 150
ISSKDICQDR AGNCPEEECN LTLNKKSRSS TAVHNSEIQE TCDAHHRGSS
160 170 180 190 200
RACTGRSKRH RSRALEVQTP SLRKSLVTSV RAMSEAVYQD LAQVWAQQIH
210 220 230 240 250
SPLTCEQLTL LTRLRGPLCA QVQTLYSMAT QAAYVFPAES WLVPATLPGP
260 270 280
GDSALDREAH PFPGQEITEP VSGSDEAKLG AP
Length:282
Mass (Da):30,798
Last modified:July 24, 2007 - v1
Checksum:iA27D0A9024909236
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121C → R.
Corresponds to variant rs13073018 [ dbSNP | Ensembl ].
VAR_060156
Natural varianti210 – 2101L → M.
Corresponds to variant rs13096122 [ dbSNP | Ensembl ].
VAR_060157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108724 Genomic DNA. No translation available.
CCDSiCCDS43108.1.
RefSeqiNP_001118231.1. NM_001124759.1.
UniGeneiHs.274541.

Genome annotation databases

EnsembliENST00000308062; ENSP00000312299; ENSG00000172969.
GeneIDi100288801.
KEGGihsa:100288801.
UCSCiuc003dpt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108724 Genomic DNA. No translation available.
CCDSiCCDS43108.1.
RefSeqiNP_001118231.1. NM_001124759.1.
UniGeneiHs.274541.

3D structure databases

ProteinModelPortaliA6NGY1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA6NGY1.

Proteomic databases

PaxDbiA6NGY1.
PRIDEiA6NGY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308062; ENSP00000312299; ENSG00000172969.
GeneIDi100288801.
KEGGihsa:100288801.
UCSCiuc003dpt.4. human.

Organism-specific databases

CTDi100288801.
GeneCardsiGC03P075728.
H-InvDBHIX0020294.
HIX0176468.
HGNCiHGNC:33626. FRG2C.
HPAiHPA039264.
HPA047769.
neXtProtiNX_A6NGY1.
PharmGKBiPA162388921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86920.
GeneTreeiENSGT00530000064266.
HOGENOMiHOG000112644.
HOVERGENiHBG106627.
InParanoidiA6NGY1.
OMAiISSKDIC.
PhylomeDBiA6NGY1.
TreeFamiTF342559.

Miscellaneous databases

GenomeRNAii100288801.
NextBioi95412.
PROiA6NGY1.

Gene expression databases

BgeeiA6NGY1.
ExpressionAtlasiA6NGY1. baseline and differential.
GenevestigatoriA6NGY1.

Family and domain databases

InterProiIPR026245. FRG2.
[Graphical view]
PANTHERiPTHR31883. PTHR31883. 1 hit.
PfamiPF15315. FRG2. 1 hit.
[Graphical view]
PRINTSiPR02074. PROTEINFRG2.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients."
    Rijkers T., Deidda G., van Koningsbruggen S., van Geel M., Lemmers R.J.L.F., van Deutekom J.C.T., Figlewicz D., Hewitt J.E., Padberg G.W., Frants R.R., van der Maarel S.M.
    J. Med. Genet. 41:826-836(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFRG2C_HUMAN
AccessioniPrimary (citable) accession number: A6NGY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: March 4, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.