ID MROH6_HUMAN Reviewed; 719 AA. AC A6NGR9; A8MWB1; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 26-FEB-2008, sequence version 2. DT 27-MAR-2024, entry version 125. DE RecName: Full=Maestro heat-like repeat-containing protein family member 6; GN Name=MROH6; Synonyms=C8orf73; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., RA Platzer M., Shimizu N., Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC067930; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS47928.1; -. DR RefSeq; NP_001094348.1; NM_001100878.1. DR AlphaFoldDB; A6NGR9; -. DR BioGRID; 567998; 7. DR IntAct; A6NGR9; 2. DR STRING; 9606.ENSP00000381857; -. DR iPTMnet; A6NGR9; -. DR PhosphoSitePlus; A6NGR9; -. DR SwissPalm; A6NGR9; -. DR BioMuta; MROH6; -. DR EPD; A6NGR9; -. DR jPOST; A6NGR9; -. DR MassIVE; A6NGR9; -. DR MaxQB; A6NGR9; -. DR PaxDb; 9606-ENSP00000381857; -. DR PeptideAtlas; A6NGR9; -. DR ProteomicsDB; 1146; -. DR Antibodypedia; 76664; 7 antibodies from 5 providers. DR DNASU; 642475; -. DR Ensembl; ENST00000398882.8; ENSP00000381857.3; ENSG00000204839.9. DR Ensembl; ENST00000618551.2; ENSP00000479227.1; ENSG00000277781.2. DR GeneID; 642475; -. DR KEGG; hsa:642475; -. DR MANE-Select; ENST00000398882.8; ENSP00000381857.3; NM_001100878.2; NP_001094348.1. DR UCSC; uc010mff.4; human. DR AGR; HGNC:27814; -. DR CTD; 642475; -. DR DisGeNET; 642475; -. DR GeneCards; MROH6; -. DR HGNC; HGNC:27814; MROH6. DR HPA; ENSG00000204839; Tissue enhanced (esophagus). DR neXtProt; NX_A6NGR9; -. DR OpenTargets; ENSG00000204839; -. DR PharmGKB; PA142672336; -. DR VEuPathDB; HostDB:ENSG00000204839; -. DR eggNOG; ENOG502SUFR; Eukaryota. DR GeneTree; ENSGT00940000162472; -. DR HOGENOM; CLU_030549_0_0_1; -. DR InParanoid; A6NGR9; -. DR OMA; HAQDVVC; -. DR OrthoDB; 4590563at2759; -. DR PhylomeDB; A6NGR9; -. DR TreeFam; TF343191; -. DR PathwayCommons; A6NGR9; -. DR SignaLink; A6NGR9; -. DR BioGRID-ORCS; 642475; 26 hits in 1152 CRISPR screens. DR ChiTaRS; MROH6; human. DR GenomeRNAi; 642475; -. DR Pharos; A6NGR9; Tdark. DR PRO; PR:A6NGR9; -. DR Proteomes; UP000005640; Chromosome 8. DR RNAct; A6NGR9; Protein. DR Bgee; ENSG00000204839; Expressed in lower esophagus mucosa and 100 other cell types or tissues. DR ExpressionAtlas; A6NGR9; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR045206; Maestro_heat-like_prot. DR InterPro; IPR048465; Maestro_HEAT_rpt. DR PANTHER; PTHR23120:SF40; MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 6; 1. DR PANTHER; PTHR23120; MAESTRO-RELATED HEAT DOMAIN-CONTAINING; 1. DR Pfam; PF21047; Maestro_HEAT; 1. DR SUPFAM; SSF48371; ARM repeat; 1. DR Genevisible; A6NGR9; HS. PE 4: Predicted; KW Reference proteome; Repeat. FT CHAIN 1..719 FT /note="Maestro heat-like repeat-containing protein family FT member 6" FT /id="PRO_0000320922" FT REPEAT 356..393 FT /note="HEAT 1" FT REPEAT 397..434 FT /note="HEAT 2" FT REPEAT 436..473 FT /note="HEAT 3" FT REPEAT 477..514 FT /note="HEAT 4" FT REPEAT 527..563 FT /note="HEAT 5" FT REPEAT 594..631 FT /note="HEAT 6" FT REPEAT 633..674 FT /note="HEAT 7" FT REGION 25..103 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 97 FT /note="H -> Q (in dbSNP:rs4873803)" FT /id="VAR_039305" FT VARIANT 132 FT /note="V -> A (in dbSNP:rs4874153)" FT /id="VAR_039306" FT VARIANT 134 FT /note="T -> I (in dbSNP:rs10866911)" FT /id="VAR_039307" FT VARIANT 619 FT /note="A -> T (in dbSNP:rs13255489)" FT /id="VAR_061595" SQ SEQUENCE 719 AA; 77186 MW; E934473EF64302AC CRC64; MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV KPEAEPQTQA LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP QSSWEEGVLA DLALYTAACL EEAGFAGTQA TVLTLSSALE ARGERLEDQV HALVRGLLAQ VPSLAEGRPW RAALRVLSAL ALEHARDVVC ALLPRSLPAD RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA ATRALGEMLA VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM VAHADHHLRG LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE VILERLLTWQ GDPEPTVRWL GLLGLGHLAL NRRKVRHVST LLPALLGALG EGDARLVGAA LGALRRLLLR PRAPVRLLSA ELGPRLPPLL DDTRDSIRAS AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH DPSRDAAESS EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ SDPKPAVAAA AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS PFQRRSVAGR WGCSGPRRA //