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A6NGR9

- MROH6_HUMAN

UniProt

A6NGR9 - MROH6_HUMAN

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Protein
Maestro heat-like repeat-containing protein family member 6
Gene
MROH6, C8orf73
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 6
Gene namesi
Name:MROH6
Synonyms:C8orf73
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:27814. MROH6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672336.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Maestro heat-like repeat-containing protein family member 6
PRO_0000320922Add
BLAST

Proteomic databases

MaxQBiA6NGR9.
PaxDbiA6NGR9.
PRIDEiA6NGR9.

PTM databases

PhosphoSiteiA6NGR9.

Expressioni

Gene expression databases

ArrayExpressiA6NGR9.
BgeeiA6NGR9.
CleanExiHS_C8orf73.
GenevestigatoriA6NGR9.

Interactioni

Protein-protein interaction databases

BioGridi567998. 2 interactions.
STRINGi9606.ENSP00000381857.

Structurei

3D structure databases

ProteinModelPortaliA6NGR9.
SMRiA6NGR9. Positions 377-513, 596-650.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati356 – 39338HEAT 1
Add
BLAST
Repeati397 – 43438HEAT 2
Add
BLAST
Repeati436 – 47338HEAT 3
Add
BLAST
Repeati477 – 51438HEAT 4
Add
BLAST
Repeati527 – 56337HEAT 5
Add
BLAST
Repeati594 – 63138HEAT 6
Add
BLAST
Repeati633 – 67442HEAT 7
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi340 – 539200Leu-rich
Add
BLAST

Sequence similaritiesi

Contains 7 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG129847.
HOGENOMiHOG000111620.
InParanoidiA6NGR9.
OMAiALYTAAC.
OrthoDBiEOG7ZSHSJ.
PhylomeDBiA6NGR9.
TreeFamiTF343191.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

A6NGR9-1 [UniParc]FASTAAdd to Basket

« Hide

MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV    50
KPEAEPQTQA LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP 100
QSSWEEGVLA DLALYTAACL EEAGFAGTQA TVLTLSSALE ARGERLEDQV 150
HALVRGLLAQ VPSLAEGRPW RAALRVLSAL ALEHARDVVC ALLPRSLPAD 200
RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA ATRALGEMLA 250
VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH 300
ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM 350
VAHADHHLRG LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE 400
VILERLLTWQ GDPEPTVRWL GLLGLGHLAL NRRKVRHVST LLPALLGALG 450
EGDARLVGAA LGALRRLLLR PRAPVRLLSA ELGPRLPPLL DDTRDSIRAS 500
AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH DPSRDAAESS 550
EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL 600
SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ 650
SDPKPAVAAA AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS 700
PFQRRSVAGR WGCSGPRRA 719
Length:719
Mass (Da):77,186
Last modified:February 26, 2008 - v2
Checksum:iE934473EF64302AC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971H → Q.
Corresponds to variant rs4873803 [ dbSNP | Ensembl ].
VAR_039305
Natural varianti132 – 1321V → A.
Corresponds to variant rs4874153 [ dbSNP | Ensembl ].
VAR_039306
Natural varianti134 – 1341T → I.
Corresponds to variant rs10866911 [ dbSNP | Ensembl ].
VAR_039307
Natural varianti619 – 6191A → T.
Corresponds to variant rs13255489 [ dbSNP | Ensembl ].
VAR_061595

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC067930 Genomic DNA. No translation available.
CCDSiCCDS47928.1.
RefSeqiNP_001094348.1. NM_001100878.1.
UniGeneiHs.531406.

Genome annotation databases

EnsembliENST00000398882; ENSP00000381857; ENSG00000204839.
GeneIDi642475.
KEGGihsa:642475.
UCSCiuc010mff.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC067930 Genomic DNA. No translation available.
CCDSi CCDS47928.1.
RefSeqi NP_001094348.1. NM_001100878.1.
UniGenei Hs.531406.

3D structure databases

ProteinModelPortali A6NGR9.
SMRi A6NGR9. Positions 377-513, 596-650.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 567998. 2 interactions.
STRINGi 9606.ENSP00000381857.

PTM databases

PhosphoSitei A6NGR9.

Proteomic databases

MaxQBi A6NGR9.
PaxDbi A6NGR9.
PRIDEi A6NGR9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398882 ; ENSP00000381857 ; ENSG00000204839 .
GeneIDi 642475.
KEGGi hsa:642475.
UCSCi uc010mff.3. human.

Organism-specific databases

CTDi 642475.
GeneCardsi GC08M144650.
HGNCi HGNC:27814. MROH6.
neXtProti NX_A6NGR9.
PharmGKBi PA142672336.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG129847.
HOGENOMi HOG000111620.
InParanoidi A6NGR9.
OMAi ALYTAAC.
OrthoDBi EOG7ZSHSJ.
PhylomeDBi A6NGR9.
TreeFami TF343191.

Miscellaneous databases

GenomeRNAii 642475.
NextBioi 113817.

Gene expression databases

ArrayExpressi A6NGR9.
Bgeei A6NGR9.
CleanExi HS_C8orf73.
Genevestigatori A6NGR9.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Entry informationi

Entry nameiMROH6_HUMAN
AccessioniPrimary (citable) accession number: A6NGR9
Secondary accession number(s): A8MWB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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