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Protein

Maestro heat-like repeat-containing protein family member 6

Gene

MROH6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 6
Gene namesi
Name:MROH6
Synonyms:C8orf73
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000204839.8.
HGNCiHGNC:27814. MROH6.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204839.
PharmGKBiPA142672336.

Polymorphism and mutation databases

BioMutaiMROH6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003209221 – 719Maestro heat-like repeat-containing protein family member 6Add BLAST719

Proteomic databases

EPDiA6NGR9.
MaxQBiA6NGR9.
PaxDbiA6NGR9.
PRIDEiA6NGR9.

PTM databases

iPTMnetiA6NGR9.
PhosphoSitePlusiA6NGR9.

Expressioni

Gene expression databases

BgeeiENSG00000204839.
CleanExiHS_C8orf73.
ExpressionAtlasiA6NGR9. baseline and differential.
GenevisibleiA6NGR9. HS.

Organism-specific databases

HPAiHPA068049.

Interactioni

Protein-protein interaction databases

BioGridi567998. 2 interactors.
IntActiA6NGR9. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliA6NGR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati356 – 393HEAT 1Add BLAST38
Repeati397 – 434HEAT 2Add BLAST38
Repeati436 – 473HEAT 3Add BLAST38
Repeati477 – 514HEAT 4Add BLAST38
Repeati527 – 563HEAT 5Add BLAST37
Repeati594 – 631HEAT 6Add BLAST38
Repeati633 – 674HEAT 7Add BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi340 – 539Leu-richAdd BLAST200

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IH0M. Eukaryota.
ENOG410ZNII. LUCA.
GeneTreeiENSGT00890000139360.
HOGENOMiHOG000111620.
InParanoidiA6NGR9.
OMAiYTAACLE.
OrthoDBiEOG091G00DQ.
PhylomeDBiA6NGR9.
TreeFamiTF343191.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

A6NGR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV
60 70 80 90 100
KPEAEPQTQA LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP
110 120 130 140 150
QSSWEEGVLA DLALYTAACL EEAGFAGTQA TVLTLSSALE ARGERLEDQV
160 170 180 190 200
HALVRGLLAQ VPSLAEGRPW RAALRVLSAL ALEHARDVVC ALLPRSLPAD
210 220 230 240 250
RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA ATRALGEMLA
260 270 280 290 300
VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH
310 320 330 340 350
ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM
360 370 380 390 400
VAHADHHLRG LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE
410 420 430 440 450
VILERLLTWQ GDPEPTVRWL GLLGLGHLAL NRRKVRHVST LLPALLGALG
460 470 480 490 500
EGDARLVGAA LGALRRLLLR PRAPVRLLSA ELGPRLPPLL DDTRDSIRAS
510 520 530 540 550
AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH DPSRDAAESS
560 570 580 590 600
EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL
610 620 630 640 650
SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ
660 670 680 690 700
SDPKPAVAAA AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS
710
PFQRRSVAGR WGCSGPRRA
Length:719
Mass (Da):77,186
Last modified:February 26, 2008 - v2
Checksum:iE934473EF64302AC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03930597H → Q. Corresponds to variant dbSNP:rs4873803Ensembl.1
Natural variantiVAR_039306132V → A. Corresponds to variant dbSNP:rs4874153Ensembl.1
Natural variantiVAR_039307134T → I. Corresponds to variant dbSNP:rs10866911Ensembl.1
Natural variantiVAR_061595619A → T. Corresponds to variant dbSNP:rs13255489Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA. No translation available.
CCDSiCCDS47928.1.
RefSeqiNP_001094348.1. NM_001100878.1.
UniGeneiHs.531406.

Genome annotation databases

EnsembliENST00000398882; ENSP00000381857; ENSG00000204839.
ENST00000618551; ENSP00000479227; ENSG00000277781.
GeneIDi642475.
KEGGihsa:642475.
UCSCiuc010mff.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMROH6_HUMAN
AccessioniPrimary (citable) accession number: A6NGR9
Secondary accession number(s): A8MWB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 27, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations