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A6NGR9 (MROH6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Maestro heat-like repeat-containing protein family member 6
Gene names
Name:MROH6
Synonyms:C8orf73
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length719 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 HEAT repeats.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 719719Maestro heat-like repeat-containing protein family member 6
PRO_0000320922

Regions

Repeat356 – 39338HEAT 1
Repeat397 – 43438HEAT 2
Repeat436 – 47338HEAT 3
Repeat477 – 51438HEAT 4
Repeat527 – 56337HEAT 5
Repeat594 – 63138HEAT 6
Repeat633 – 67442HEAT 7
Compositional bias340 – 539200Leu-rich

Natural variations

Natural variant971H → Q.
Corresponds to variant rs4873803 [ dbSNP | Ensembl ].
VAR_039305
Natural variant1321V → A.
Corresponds to variant rs4874153 [ dbSNP | Ensembl ].
VAR_039306
Natural variant1341T → I.
Corresponds to variant rs10866911 [ dbSNP | Ensembl ].
VAR_039307
Natural variant6191A → T.
Corresponds to variant rs13255489 [ dbSNP | Ensembl ].
VAR_061595

Sequences

Sequence LengthMass (Da)Tools
A6NGR9 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: E934473EF64302AC

FASTA71977,186
        10         20         30         40         50         60 
MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV KPEAEPQTQA 

        70         80         90        100        110        120 
LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP QSSWEEGVLA DLALYTAACL 

       130        140        150        160        170        180 
EEAGFAGTQA TVLTLSSALE ARGERLEDQV HALVRGLLAQ VPSLAEGRPW RAALRVLSAL 

       190        200        210        220        230        240 
ALEHARDVVC ALLPRSLPAD RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA 

       250        260        270        280        290        300 
ATRALGEMLA VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH 

       310        320        330        340        350        360 
ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM VAHADHHLRG 

       370        380        390        400        410        420 
LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE VILERLLTWQ GDPEPTVRWL 

       430        440        450        460        470        480 
GLLGLGHLAL NRRKVRHVST LLPALLGALG EGDARLVGAA LGALRRLLLR PRAPVRLLSA 

       490        500        510        520        530        540 
ELGPRLPPLL DDTRDSIRAS AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH 

       550        560        570        580        590        600 
DPSRDAAESS EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL 

       610        620        630        640        650        660 
SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ SDPKPAVAAA 

       670        680        690        700        710 
AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS PFQRRSVAGR WGCSGPRRA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC067930 Genomic DNA. No translation available.
CCDSCCDS47928.1.
RefSeqNP_001094348.1. NM_001100878.1.
UniGeneHs.531406.

3D structure databases

ProteinModelPortalA6NGR9.
SMRA6NGR9. Positions 377-513, 596-650.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid567998. 2 interactions.
STRING9606.ENSP00000381857.

PTM databases

PhosphoSiteA6NGR9.

Proteomic databases

MaxQBA6NGR9.
PaxDbA6NGR9.
PRIDEA6NGR9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398882; ENSP00000381857; ENSG00000204839.
GeneID642475.
KEGGhsa:642475.
UCSCuc010mff.3. human.

Organism-specific databases

CTD642475.
GeneCardsGC08M144650.
HGNCHGNC:27814. MROH6.
neXtProtNX_A6NGR9.
PharmGKBPA142672336.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG129847.
HOGENOMHOG000111620.
InParanoidA6NGR9.
OMAALYTAAC.
OrthoDBEOG7ZSHSJ.
PhylomeDBA6NGR9.
TreeFamTF343191.

Gene expression databases

ArrayExpressA6NGR9.
BgeeA6NGR9.
CleanExHS_C8orf73.
GenevestigatorA6NGR9.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
ProtoNetSearch...

Other

GenomeRNAi642475.
NextBio113817.

Entry information

Entry nameMROH6_HUMAN
AccessionPrimary (citable) accession number: A6NGR9
Secondary accession number(s): A8MWB1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM