Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Maestro heat-like repeat-containing protein family member 6

Gene

MROH6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 6
Gene namesi
Name:MROH6
Synonyms:C8orf73
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:27814. MROH6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672336.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Maestro heat-like repeat-containing protein family member 6PRO_0000320922Add
BLAST

Proteomic databases

MaxQBiA6NGR9.
PaxDbiA6NGR9.
PRIDEiA6NGR9.

PTM databases

PhosphoSiteiA6NGR9.

Expressioni

Gene expression databases

BgeeiA6NGR9.
CleanExiHS_C8orf73.
ExpressionAtlasiA6NGR9. baseline and differential.
GenevestigatoriA6NGR9.

Interactioni

Protein-protein interaction databases

BioGridi567998. 1 interaction.
STRINGi9606.ENSP00000381857.

Structurei

3D structure databases

ProteinModelPortaliA6NGR9.
SMRiA6NGR9. Positions 365-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati356 – 39338HEAT 1Add
BLAST
Repeati397 – 43438HEAT 2Add
BLAST
Repeati436 – 47338HEAT 3Add
BLAST
Repeati477 – 51438HEAT 4Add
BLAST
Repeati527 – 56337HEAT 5Add
BLAST
Repeati594 – 63138HEAT 6Add
BLAST
Repeati633 – 67442HEAT 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi340 – 539200Leu-richAdd
BLAST

Sequence similaritiesi

Contains 7 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG129847.
GeneTreeiENSGT00780000121913.
HOGENOMiHOG000111620.
InParanoidiA6NGR9.
OMAiQSSWEEG.
OrthoDBiEOG7ZSHSJ.
PhylomeDBiA6NGR9.
TreeFamiTF343191.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

A6NGR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV
60 70 80 90 100
KPEAEPQTQA LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP
110 120 130 140 150
QSSWEEGVLA DLALYTAACL EEAGFAGTQA TVLTLSSALE ARGERLEDQV
160 170 180 190 200
HALVRGLLAQ VPSLAEGRPW RAALRVLSAL ALEHARDVVC ALLPRSLPAD
210 220 230 240 250
RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA ATRALGEMLA
260 270 280 290 300
VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH
310 320 330 340 350
ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM
360 370 380 390 400
VAHADHHLRG LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE
410 420 430 440 450
VILERLLTWQ GDPEPTVRWL GLLGLGHLAL NRRKVRHVST LLPALLGALG
460 470 480 490 500
EGDARLVGAA LGALRRLLLR PRAPVRLLSA ELGPRLPPLL DDTRDSIRAS
510 520 530 540 550
AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH DPSRDAAESS
560 570 580 590 600
EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL
610 620 630 640 650
SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ
660 670 680 690 700
SDPKPAVAAA AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS
710
PFQRRSVAGR WGCSGPRRA
Length:719
Mass (Da):77,186
Last modified:February 26, 2008 - v2
Checksum:iE934473EF64302AC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971H → Q.
Corresponds to variant rs4873803 [ dbSNP | Ensembl ].
VAR_039305
Natural varianti132 – 1321V → A.
Corresponds to variant rs4874153 [ dbSNP | Ensembl ].
VAR_039306
Natural varianti134 – 1341T → I.
Corresponds to variant rs10866911 [ dbSNP | Ensembl ].
VAR_039307
Natural varianti619 – 6191A → T.
Corresponds to variant rs13255489 [ dbSNP | Ensembl ].
VAR_061595

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA. No translation available.
CCDSiCCDS47928.1.
RefSeqiNP_001094348.1. NM_001100878.1.
UniGeneiHs.531406.

Genome annotation databases

EnsembliENST00000398882; ENSP00000381857; ENSG00000204839.
ENST00000618551; ENSP00000479227; ENSG00000277781.
GeneIDi642475.
KEGGihsa:642475.
UCSCiuc010mff.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA. No translation available.
CCDSiCCDS47928.1.
RefSeqiNP_001094348.1. NM_001100878.1.
UniGeneiHs.531406.

3D structure databases

ProteinModelPortaliA6NGR9.
SMRiA6NGR9. Positions 365-510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi567998. 1 interaction.
STRINGi9606.ENSP00000381857.

PTM databases

PhosphoSiteiA6NGR9.

Proteomic databases

MaxQBiA6NGR9.
PaxDbiA6NGR9.
PRIDEiA6NGR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398882; ENSP00000381857; ENSG00000204839.
ENST00000618551; ENSP00000479227; ENSG00000277781.
GeneIDi642475.
KEGGihsa:642475.
UCSCiuc010mff.3. human.

Organism-specific databases

CTDi642475.
GeneCardsiGC08M144650.
HGNCiHGNC:27814. MROH6.
neXtProtiNX_A6NGR9.
PharmGKBiPA142672336.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG129847.
GeneTreeiENSGT00780000121913.
HOGENOMiHOG000111620.
InParanoidiA6NGR9.
OMAiQSSWEEG.
OrthoDBiEOG7ZSHSJ.
PhylomeDBiA6NGR9.
TreeFamiTF343191.

Miscellaneous databases

GenomeRNAii642475.
NextBioi113817.

Gene expression databases

BgeeiA6NGR9.
CleanExiHS_C8orf73.
ExpressionAtlasiA6NGR9. baseline and differential.
GenevestigatoriA6NGR9.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMROH6_HUMAN
AccessioniPrimary (citable) accession number: A6NGR9
Secondary accession number(s): A8MWB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 4, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.