A6NGR9 (MROH6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maestro heat-like repeat-containing protein family member 6

Gene names

Name:	MROH6
Synonyms:	C8orf73

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	719 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 HEAT repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 719	719	Maestro heat-like repeat-containing protein family member 6		PRO_0000320922
Regions
	Repeat	356 – 393	38	HEAT 1
	Repeat	397 – 434	38	HEAT 2
	Repeat	436 – 473	38	HEAT 3
	Repeat	477 – 514	38	HEAT 4
	Repeat	527 – 563	37	HEAT 5
	Repeat	594 – 631	38	HEAT 6
	Repeat	633 – 674	42	HEAT 7
	Compositional bias	340 – 539	200	Leu-rich
Natural variations
	Natural variant	97	1	H → Q. Corresponds to variant rs4873803 [ dbSNP | Ensembl ].		VAR_039305
	Natural variant	132	1	V → A. Corresponds to variant rs4874153 [ dbSNP | Ensembl ].		VAR_039306
	Natural variant	134	1	T → I. Corresponds to variant rs10866911 [ dbSNP | Ensembl ].		VAR_039307
	Natural variant	619	1	A → T. Corresponds to variant rs13255489 [ dbSNP | Ensembl ].		VAR_061595

Sequences

	Sequence		Length	Mass (Da)
	A6NGR9 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: E934473EF64302AC	FASTA	719	77,186
	10 20 30 40 50 60 MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV KPEAEPQTQA 70 80 90 100 110 120 LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP QSSWEEGVLA DLALYTAACL 130 140 150 160 170 180 EEAGFAGTQA TVLTLSSALE ARGERLEDQV HALVRGLLAQ VPSLAEGRPW RAALRVLSAL 190 200 210 220 230 240 ALEHARDVVC ALLPRSLPAD RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA 250 260 270 280 290 300 ATRALGEMLA VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH 310 320 330 340 350 360 ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM VAHADHHLRG 370 380 390 400 410 420 LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE VILERLLTWQ GDPEPTVRWL 430 440 450 460 470 480 GLLGLGHLAL NRRKVRHVST LLPALLGALG EGDARLVGAA LGALRRLLLR PRAPVRLLSA 490 500 510 520 530 540 ELGPRLPPLL DDTRDSIRAS AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH 550 560 570 580 590 600 DPSRDAAESS EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL 610 620 630 640 650 660 SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ SDPKPAVAAA 670 680 690 700 710 AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS PFQRRSVAGR WGCSGPRRA

References

[1]

"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC067930 Genomic DNA. No translation available.
IPI	IPI00741030.
RefSeq	NP_001094348.1. NM_001100878.1.
UniGene	Hs.531406.
3D structure databases
ProteinModelPortal	A6NGR9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381857.
PTM databases
PhosphoSite	A6NGR9.
Proteomic databases
PaxDb	A6NGR9.
PRIDE	A6NGR9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398882; ENSP00000381857; ENSG00000204839.
GeneID	642475.
KEGG	hsa:642475.
UCSC	uc010mff.3. human.
Organism-specific databases
CTD	642475.
GeneCards	GC08M144649.
HGNC	HGNC:27814. MROH6.
neXtProt	NX_A6NGR9.
PharmGKB	PA142672336.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG129847.
HOGENOM	HOG000111620.
InParanoid	A6NGR9.
OMA	QSSWEEG.
OrthoDB	EOG4VX250.
Gene expression databases
ArrayExpress	A6NGR9.
Bgee	A6NGR9.
CleanEx	HS_C8orf73.
Genevestigator	A6NGR9.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	642475.
NextBio	113817.

Entry information

Entry name

MROH6_HUMAN

Accession

Primary (citable) accession number: A6NGR9
Secondary accession number(s): A8MWB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.