Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A6NGR9

- MROH6_HUMAN

UniProt

A6NGR9 - MROH6_HUMAN

Protein

Maestro heat-like repeat-containing protein family member 6

Gene

MROH6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Maestro heat-like repeat-containing protein family member 6
    Gene namesi
    Name:MROH6
    Synonyms:C8orf73
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:27814. MROH6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672336.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 719719Maestro heat-like repeat-containing protein family member 6PRO_0000320922Add
    BLAST

    Proteomic databases

    MaxQBiA6NGR9.
    PaxDbiA6NGR9.
    PRIDEiA6NGR9.

    PTM databases

    PhosphoSiteiA6NGR9.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NGR9.
    BgeeiA6NGR9.
    CleanExiHS_C8orf73.
    GenevestigatoriA6NGR9.

    Interactioni

    Protein-protein interaction databases

    BioGridi567998. 2 interactions.
    STRINGi9606.ENSP00000381857.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NGR9.
    SMRiA6NGR9. Positions 377-513, 596-650.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati356 – 39338HEAT 1Add
    BLAST
    Repeati397 – 43438HEAT 2Add
    BLAST
    Repeati436 – 47338HEAT 3Add
    BLAST
    Repeati477 – 51438HEAT 4Add
    BLAST
    Repeati527 – 56337HEAT 5Add
    BLAST
    Repeati594 – 63138HEAT 6Add
    BLAST
    Repeati633 – 67442HEAT 7Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi340 – 539200Leu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 7 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG129847.
    HOGENOMiHOG000111620.
    InParanoidiA6NGR9.
    OMAiALYTAAC.
    OrthoDBiEOG7ZSHSJ.
    PhylomeDBiA6NGR9.
    TreeFamiTF343191.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    A6NGR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV    50
    KPEAEPQTQA LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP 100
    QSSWEEGVLA DLALYTAACL EEAGFAGTQA TVLTLSSALE ARGERLEDQV 150
    HALVRGLLAQ VPSLAEGRPW RAALRVLSAL ALEHARDVVC ALLPRSLPAD 200
    RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA ATRALGEMLA 250
    VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH 300
    ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM 350
    VAHADHHLRG LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE 400
    VILERLLTWQ GDPEPTVRWL GLLGLGHLAL NRRKVRHVST LLPALLGALG 450
    EGDARLVGAA LGALRRLLLR PRAPVRLLSA ELGPRLPPLL DDTRDSIRAS 500
    AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH DPSRDAAESS 550
    EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL 600
    SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ 650
    SDPKPAVAAA AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS 700
    PFQRRSVAGR WGCSGPRRA 719
    Length:719
    Mass (Da):77,186
    Last modified:February 26, 2008 - v2
    Checksum:iE934473EF64302AC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971H → Q.
    Corresponds to variant rs4873803 [ dbSNP | Ensembl ].
    VAR_039305
    Natural varianti132 – 1321V → A.
    Corresponds to variant rs4874153 [ dbSNP | Ensembl ].
    VAR_039306
    Natural varianti134 – 1341T → I.
    Corresponds to variant rs10866911 [ dbSNP | Ensembl ].
    VAR_039307
    Natural varianti619 – 6191A → T.
    Corresponds to variant rs13255489 [ dbSNP | Ensembl ].
    VAR_061595

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067930 Genomic DNA. No translation available.
    CCDSiCCDS47928.1.
    RefSeqiNP_001094348.1. NM_001100878.1.
    UniGeneiHs.531406.

    Genome annotation databases

    EnsembliENST00000398882; ENSP00000381857; ENSG00000204839.
    GeneIDi642475.
    KEGGihsa:642475.
    UCSCiuc010mff.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067930 Genomic DNA. No translation available.
    CCDSi CCDS47928.1.
    RefSeqi NP_001094348.1. NM_001100878.1.
    UniGenei Hs.531406.

    3D structure databases

    ProteinModelPortali A6NGR9.
    SMRi A6NGR9. Positions 377-513, 596-650.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 567998. 2 interactions.
    STRINGi 9606.ENSP00000381857.

    PTM databases

    PhosphoSitei A6NGR9.

    Proteomic databases

    MaxQBi A6NGR9.
    PaxDbi A6NGR9.
    PRIDEi A6NGR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398882 ; ENSP00000381857 ; ENSG00000204839 .
    GeneIDi 642475.
    KEGGi hsa:642475.
    UCSCi uc010mff.3. human.

    Organism-specific databases

    CTDi 642475.
    GeneCardsi GC08M144650.
    HGNCi HGNC:27814. MROH6.
    neXtProti NX_A6NGR9.
    PharmGKBi PA142672336.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG129847.
    HOGENOMi HOG000111620.
    InParanoidi A6NGR9.
    OMAi ALYTAAC.
    OrthoDBi EOG7ZSHSJ.
    PhylomeDBi A6NGR9.
    TreeFami TF343191.

    Miscellaneous databases

    GenomeRNAii 642475.
    NextBioi 113817.

    Gene expression databases

    ArrayExpressi A6NGR9.
    Bgeei A6NGR9.
    CleanExi HS_C8orf73.
    Genevestigatori A6NGR9.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    ProtoNeti Search...

    Entry informationi

    Entry nameiMROH6_HUMAN
    AccessioniPrimary (citable) accession number: A6NGR9
    Secondary accession number(s): A8MWB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3