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Protein

Oocyte-expressed protein homolog

Gene

OOEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Oocyte-expressed protein homolog
Alternative name(s):
KH homology domain-containing protein 2
Oocyte- and embryo-specific protein 19
Short name:
hOEP19
Gene namesi
Name:OOEP
Synonyms:C6orf156, KHDC2, OEP19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000203907.9.
HGNCiHGNC:21382. OOEP.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203907.
PharmGKBiPA162398414.

Polymorphism and mutation databases

BioMutaiOOEP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288021 – 149Oocyte-expressed protein homologAdd BLAST149

Proteomic databases

PaxDbiA6NGQ2.
PRIDEiA6NGQ2.

Expressioni

Gene expression databases

BgeeiENSG00000203907.
CleanExiHS_OOEP.
ExpressionAtlasiA6NGQ2. baseline and differential.
GenevisibleiA6NGQ2. HS.

Organism-specific databases

HPAiHPA055165.

Interactioni

Subunit structurei

Component of the SCMC which also includes at least KHDC3L, NLRP5 and TLE6.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000359384.

Structurei

3D structure databases

ProteinModelPortaliA6NGQ2.
SMRiA6NGQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 110KH; atypicalAdd BLAST62

Domaini

Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.

Sequence similaritiesi

Belongs to the KHDC1 family.Curated

Phylogenomic databases

eggNOGiENOG410IYS7. Eukaryota.
ENOG4111410. LUCA.
GeneTreeiENSGT00560000077310.
HOGENOMiHOG000037927.
HOVERGENiHBG108215.
InParanoidiA6NGQ2.
OMAiRIRPWWF.
OrthoDBiEOG091G0RFW.
PhylomeDBiA6NGQ2.
TreeFamiTF338690.

Family and domain databases

CDDicd12795. FILIA_N_like. 1 hit.
InterProiView protein in InterPro
IPR031952. MOEP19_KH-like.
PfamiView protein in Pfam
PF16005. MOEP19. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NGQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDDAGAAES QRGKQTPAHS LEQLRRLPLP PPQIRIRPWW FPVQELRDPL
60 70 80 90 100
VFYLEAWLAD ELFGPDRAII PEMEWTSQAL LTVDIVDSGN LVEITVFGRP
110 120 130 140
RVQNRVKSML LCLAWFHREH RARAEKMKHL EKNLKAHASD PHSPQDPVA
Length:149
Mass (Da):17,170
Last modified:October 5, 2010 - v3
Checksum:iE7C726FB46909404
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04252318A → T. Corresponds to variant dbSNP:rs2280286Ensembl.1
Natural variantiVAR_04252492V → A1 PublicationCorresponds to variant dbSNP:rs496530Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU290647 mRNA. Translation: ABX84389.1.
AC019205 Genomic DNA. No translation available.
CCDSiCCDS47451.1.
RefSeqiNP_001073976.1. NM_001080507.2.
UniGeneiHs.671212.

Genome annotation databases

EnsembliENST00000370359; ENSP00000359384; ENSG00000203907.
GeneIDi441161.
KEGGihsa:441161.
UCSCiuc003pgu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOOEP_HUMAN
AccessioniPrimary (citable) accession number: A6NGQ2
Secondary accession number(s): A6NIN5, A9UIB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 5, 2010
Last modified: September 27, 2017
This is version 72 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families