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Protein

IgLON family member 5

Gene

IGLON5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
IgLON family member 5
Gene namesi
Name:IGLON5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142549.9.
HGNCiHGNC:34550. IGLON5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi402665.
OpenTargetsiENSG00000142549.
PharmGKBiPA164720915.

Polymorphism and mutation databases

BioMutaiIGLON5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000033230131 – 336IgLON family member 5Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi54 ↔ 112
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 195
Disulfide bondi238 ↔ 291
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiA6NGN9.
PaxDbiA6NGN9.
PRIDEiA6NGN9.

PTM databases

iPTMnetiA6NGN9.
PhosphoSitePlusiA6NGN9.

Expressioni

Gene expression databases

BgeeiENSG00000142549.
GenevisibleiA6NGN9. HS.

Organism-specific databases

HPAiHPA041994.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000270642.

Structurei

3D structure databases

ProteinModelPortaliA6NGN9.
SMRiA6NGN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 122Ig-like C2-type 1Add BLAST90
Domaini132 – 217Ig-like C2-type 2Add BLAST86
Domaini218 – 307Ig-like C2-type 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD5S. Eukaryota.
ENOG41102WA. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
InParanoidiA6NGN9.
KOiK06773.
OMAiVTHTERK.
OrthoDBiEOG091G0B5D.
PhylomeDBiA6NGN9.
TreeFamiTF325565.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NGN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPAPGARL RLLAAAALAG LAVISRGLLS QSLEFNSPAD NYTVCEGDNA
60 70 80 90 100
TLSCFIDEHV TRVAWLNRSN ILYAGNDRWT SDPRVRLLIN TPEEFSILIT
110 120 130 140 150
EVGLGDEGLY TCSFQTRHQP YTTQVYLIVH VPARIVNISS PVTVNEGGNV
160 170 180 190 200
NLLCLAVGRP EPTVTWRQLR DGFTSEGEIL EISDIQRGQA GEYECVTHNG
210 220 230 240 250
VNSAPDSRRV LVTVNYPPTI TDVTSARTAL GRAALLRCEA MAVPPADFQW
260 270 280 290 300
YKDDRLLSSG TAEGLKVQTE RTRSMLLFAN VSARHYGNYT CRAANRLGAS
310 320 330
SASMRLLRPG SLENSAPRPP GLLALLSALG WLWWRM
Length:336
Mass (Da):36,795
Last modified:October 14, 2008 - v4
Checksum:i9C1AD42E4BDC562B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC063977 Genomic DNA. No translation available.
CR592222 mRNA. No translation available.
CCDSiCCDS46158.1.
RefSeqiNP_001094842.1. NM_001101372.1.

Genome annotation databases

EnsembliENST00000270642; ENSP00000270642; ENSG00000142549.
GeneIDi402665.
KEGGihsa:402665.
UCSCiuc002pwc.3. human.

Similar proteinsi

Entry informationi

Entry nameiIGLO5_HUMAN
AccessioniPrimary (citable) accession number: A6NGN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 14, 2008
Last modified: November 22, 2017
This is version 87 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families