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Protein

IgLON family member 5

Gene

IGLON5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31447-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
IgLON family member 5
Gene namesi
Name:IGLON5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34550. IGLON5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142549.
PharmGKBiPA164720915.

Polymorphism and mutation databases

BioMutaiIGLON5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000033230131 – 336IgLON family member 5Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi54 ↔ 112PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi154 ↔ 195PROSITE-ProRule annotation
Disulfide bondi238 ↔ 291PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NGN9.
PRIDEiA6NGN9.

PTM databases

iPTMnetiA6NGN9.
PhosphoSitePlusiA6NGN9.

Expressioni

Gene expression databases

BgeeiENSG00000142549.
GenevisibleiA6NGN9. HS.

Organism-specific databases

HPAiHPA041994.
HPA048263.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000270642.

Structurei

3D structure databases

ProteinModelPortaliA6NGN9.
SMRiA6NGN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 122Ig-like C2-type 1Add BLAST90
Domaini132 – 217Ig-like C2-type 2Add BLAST86
Domaini218 – 307Ig-like C2-type 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD5S. Eukaryota.
ENOG41102WA. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
InParanoidiA6NGN9.
KOiK06773.
OMAiNGFTSEG.
OrthoDBiEOG091G0B5D.
PhylomeDBiA6NGN9.
TreeFamiTF325565.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NGN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPAPGARL RLLAAAALAG LAVISRGLLS QSLEFNSPAD NYTVCEGDNA
60 70 80 90 100
TLSCFIDEHV TRVAWLNRSN ILYAGNDRWT SDPRVRLLIN TPEEFSILIT
110 120 130 140 150
EVGLGDEGLY TCSFQTRHQP YTTQVYLIVH VPARIVNISS PVTVNEGGNV
160 170 180 190 200
NLLCLAVGRP EPTVTWRQLR DGFTSEGEIL EISDIQRGQA GEYECVTHNG
210 220 230 240 250
VNSAPDSRRV LVTVNYPPTI TDVTSARTAL GRAALLRCEA MAVPPADFQW
260 270 280 290 300
YKDDRLLSSG TAEGLKVQTE RTRSMLLFAN VSARHYGNYT CRAANRLGAS
310 320 330
SASMRLLRPG SLENSAPRPP GLLALLSALG WLWWRM
Length:336
Mass (Da):36,795
Last modified:October 14, 2008 - v4
Checksum:i9C1AD42E4BDC562B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC063977 Genomic DNA. No translation available.
CR592222 mRNA. No translation available.
CCDSiCCDS46158.1.
RefSeqiNP_001094842.1. NM_001101372.1.
UniGeneiHs.546636.

Genome annotation databases

EnsembliENST00000270642; ENSP00000270642; ENSG00000142549.
GeneIDi402665.
KEGGihsa:402665.
UCSCiuc002pwc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC063977 Genomic DNA. No translation available.
CR592222 mRNA. No translation available.
CCDSiCCDS46158.1.
RefSeqiNP_001094842.1. NM_001101372.1.
UniGeneiHs.546636.

3D structure databases

ProteinModelPortaliA6NGN9.
SMRiA6NGN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000270642.

PTM databases

iPTMnetiA6NGN9.
PhosphoSitePlusiA6NGN9.

Polymorphism and mutation databases

BioMutaiIGLON5.

Proteomic databases

PaxDbiA6NGN9.
PRIDEiA6NGN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270642; ENSP00000270642; ENSG00000142549.
GeneIDi402665.
KEGGihsa:402665.
UCSCiuc002pwc.3. human.

Organism-specific databases

CTDi402665.
GeneCardsiIGLON5.
HGNCiHGNC:34550. IGLON5.
HPAiHPA041994.
HPA048263.
neXtProtiNX_A6NGN9.
OpenTargetsiENSG00000142549.
PharmGKBiPA164720915.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KD5S. Eukaryota.
ENOG41102WA. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
InParanoidiA6NGN9.
KOiK06773.
OMAiNGFTSEG.
OrthoDBiEOG091G0B5D.
PhylomeDBiA6NGN9.
TreeFamiTF325565.

Enzyme and pathway databases

BioCyciZFISH:G66-31447-MONOMER.

Miscellaneous databases

ChiTaRSiIGLON5. human.
GenomeRNAii402665.
PROiA6NGN9.

Gene expression databases

BgeeiENSG00000142549.
GenevisibleiA6NGN9. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGLO5_HUMAN
AccessioniPrimary (citable) accession number: A6NGN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 78 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.