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Protein

PRAME family member 25

Gene

PRAMEF25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 25Imported
Gene namesi
Name:PRAMEF25Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000229571.6
HostDB:ENSG00000280267.3
HGNCiHGNC:49179 PRAMEF25
neXtProtiNX_A6NGN4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000229571
ENSG00000280267

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003489401 – 478PRAME family member 25Add BLAST478

Proteomic databases

PRIDEiA6NGN4

PTM databases

iPTMnetiA6NGN4
PhosphoSitePlusiA6NGN4

Expressioni

Gene expression databases

BgeeiENSG00000229571
GenevisibleiA6NGN4 HS

Structurei

3D structure databases

ProteinModelPortaliA6NGN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 126LRR 1; degenerateBy similarityAdd BLAST28
Repeati181 – 205LRR 2; degenerateBy similarityAdd BLAST25
Repeati206 – 232LRR 3; degenerateBy similarityAdd BLAST27
Repeati233 – 268LRR 4; degenerateBy similarityAdd BLAST36
Repeati269 – 294LRR 5By similarityAdd BLAST26
Repeati295 – 326LRR 6By similarityAdd BLAST32
Repeati327 – 347LRR 7By similarityAdd BLAST21
Repeati351 – 378LRR 8By similarityAdd BLAST28
Repeati379 – 403LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00760000119028
HOVERGENiHBG006326
InParanoidiA6NGN4
OMAiCGENICY
OrthoDBiEOG091G05PP

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequencei

Sequence statusi: Complete.

A6NGN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMSIRTPPR LLELAGRSVL RDQALAMSTL EELPTELFPP LFMEAFSRRR
60 70 80 90 100
CEALKLMVQA WPFRRLPLRP LIKMPCLETF QAVLNGLDAL LTHGVRPRRW
110 120 130 140 150
KLQVLDLQDV CENFWMVWSE AMARGCFLNA KRNKKPVQDC PRMRGRQPLT
160 170 180 190 200
VFVELWLKNR TLDEHLTCLL LWVKQRKDLL HLCCKKLKIL GMPFRNIRSI
210 220 230 240 250
LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLV LSHMDVSRYV
260 270 280 290 300
SPEQKKEIVT QFTTQFLKLH CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
310 320 330 340 350
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV
360 370 380 390 400
AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PISMATLENL
410 420 430 440 450
LSHTIILKNL CLELYPAPRE SYGADGTLCW SRFTQIRAEL MKRVRDLRHP
460 470
KRILFGTDYC PDCGNRSFYD LEADQYCC
Length:478
Mass (Da):55,354
Last modified:November 26, 2014 - v2
Checksum:iED86A6A6A0FD601C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245056 Genomic DNA No translation available.
CCDSiCCDS81265.1
RefSeqiNP_001293001.1, NM_001306072.1
NP_001297063.1, NM_001310134.1

Genome annotation databases

EnsembliENST00000613059; ENSP00000481973; ENSG00000276299
ENST00000614839; ENSP00000481683; ENSG00000229571
ENST00000619661; ENSP00000478309; ENSG00000229571
ENST00000632559; ENSP00000488003; ENSG00000282566
ENST00000634012; ENSP00000488324; ENSG00000282566
ENST00000635813; ENSP00000490751; ENSG00000283348
ENST00000636290; ENSP00000490779; ENSG00000283348
GeneIDi441873
645359
KEGGihsa:441873
hsa:645359
UCSCiuc057cks.1 human

Similar proteinsi

Entry informationi

Entry nameiPRA25_HUMAN
AccessioniPrimary (citable) accession number: A6NGN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 26, 2014
Last modified: March 28, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health