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A6NGK3

- GAG10_HUMAN

UniProt

A6NGK3 - GAG10_HUMAN

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Protein
G antigen 10
Gene
GAGE10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 10
Short name:
GAGE-10
Gene namesi
Name:GAGE10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:30968. GAGE10.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116G antigen 10
PRO_0000337202Add
BLAST

Proteomic databases

PaxDbiA6NGK3.
PRIDEiA6NGK3.

PTM databases

PhosphoSiteiA6NGK3.

Expressioni

Gene expression databases

BgeeiA6NGK3.
GenevestigatoriA6NGK3.

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385415.

Structurei

3D structure databases

ProteinModelPortaliA6NGK3.

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.

Phylogenomic databases

eggNOGiNOG293879.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiA6NGK3.
OMAiMEPLEVI.
OrthoDBiEOG7XM316.
PhylomeDBiA6NGK3.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NGK3-1 [UniParc]FASTAAdd to Basket

« Hide

MSWRGRSTYR SRPRLYVEPP EMIGPMLPEQ FSDEVEPATP EEGEPATQRQ    50
DPAAAQEGED EGASAGQGPK PEADSQEQVH PKTGCECGDG PDGQEMGLPN 100
PEEVKRPEEG EKQSQC 116
Length:116
Mass (Da):12,651
Last modified:July 24, 2007 - v1
Checksum:i155BC5F36E0EEB17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235097 Genomic DNA. No translation available.
CCDSiCCDS43938.1.

Genome annotation databases

EnsembliENST00000407599; ENSP00000385415; ENSG00000215274.
KEGGihsa:102724473.
UCSCiuc010nir.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235097 Genomic DNA. No translation available.
CCDSi CCDS43938.1.

3D structure databases

ProteinModelPortali A6NGK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000385415.

PTM databases

PhosphoSitei A6NGK3.

Proteomic databases

PaxDbi A6NGK3.
PRIDEi A6NGK3.

Protocols and materials databases

DNASUi 643832.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000407599 ; ENSP00000385415 ; ENSG00000215274 .
KEGGi hsa:102724473.
UCSCi uc010nir.1. human.

Organism-specific databases

CTDi 102724473.
GeneCardsi GC0XP049160.
HGNCi HGNC:30968. GAGE10.
HPAi HPA043232.
MIMi 300737. gene.
neXtProti NX_A6NGK3.
PharmGKBi PA145148765.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293879.
HOGENOMi HOG000237345.
HOVERGENi HBG056227.
InParanoidi A6NGK3.
OMAi MEPLEVI.
OrthoDBi EOG7XM316.
PhylomeDBi A6NGK3.
TreeFami TF340669.

Miscellaneous databases

ChiTaRSi GAGE10. human.
GenomeRNAii 643832.
NextBioi 115437.
PROi A6NGK3.
SOURCEi Search...

Gene expression databases

Bgeei A6NGK3.
Genevestigatori A6NGK3.

Family and domain databases

InterProi IPR008625. GAGE.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGAG10_HUMAN
AccessioniPrimary (citable) accession number: A6NGK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. 1 Publication presented a new GAGE gene nomenclature based on the identified genes and their products.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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