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Protein

G antigen 10

Gene

GAGE10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 10
Short name:
GAGE-10
Gene namesi
Name:GAGE10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000215274.5
HGNCiHGNC:30968 GAGE10
MIMi300737 gene
neXtProtiNX_A6NGK3

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148765

Polymorphism and mutation databases

BioMutaiGAGE10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003372021 – 116G antigen 10Add BLAST116

Proteomic databases

MaxQBiA6NGK3
PaxDbiA6NGK3
PRIDEiA6NGK3
ProteomicsDBi1135

PTM databases

iPTMnetiA6NGK3
PhosphoSitePlusiA6NGK3

Expressioni

Gene expression databases

BgeeiENSG00000215274
GenevisibleiA6NGK3 HS

Organism-specific databases

HPAiHPA043232

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiA6NGK3, 2 interactors
STRINGi9606.ENSP00000385415

Structurei

3D structure databases

ProteinModelPortaliA6NGK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiA6NGK3
OrthoDBiEOG091G0UGV
PhylomeDBiA6NGK3
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

A6NGK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR SRPRLYVEPP EMIGPMLPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGED EGASAGQGPK PEADSQEQVH PKTGCECGDG PDGQEMGLPN
110
PEEVKRPEEG EKQSQC
Length:116
Mass (Da):12,651
Last modified:July 24, 2007 - v1
Checksum:i155BC5F36E0EEB17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235097 Genomic DNA No translation available.
CCDSiCCDS78483.1

Genome annotation databases

EnsembliENST00000407599; ENSP00000385415; ENSG00000215274
UCSCiuc033ede.2 human

Similar proteinsi

Entry informationi

Entry nameiGAG10_HUMAN
AccessioniPrimary (citable) accession number: A6NGK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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