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A6NGE7

- URAD_HUMAN

UniProt

A6NGE7 - URAD_HUMAN

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Protein

Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Gene
URAD, PRHOXNB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein uncertaini

Functioni

Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin Reviewed prediction.

Catalytic activityi

5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton donor Reviewed prediction
Binding sitei68 – 681Substrate; via carbonyl oxygen Reviewed prediction

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB

GO - Biological processi

  1. allantoin biosynthetic process Source: InterPro
  2. purine nucleobase metabolic process Source: UniProtKB-KW
  3. urate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

UniPathwayiUPA00394; UER00652.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (EC:4.1.1.97)
Short name:
OHCU decarboxylase
Alternative name(s):
Parahox neighbor
Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
Gene namesi
Name:URAD
Synonyms:PRHOXNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:17785. URAD.

Subcellular locationi

Peroxisome Reviewed prediction

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylasePRO_0000315240Add
BLAST

Proteomic databases

PaxDbiA6NGE7.
PRIDEiA6NGE7.

PTM databases

PhosphoSiteiA6NGE7.

Expressioni

Tissue specificityi

Apparently not expressed.1 Publication

Gene expression databases

CleanExiHS_PRHOXNB.
GenevestigatoriA6NGE7.

Organism-specific databases

HPAiHPA038972.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333490.

Structurei

3D structure databases

ProteinModelPortaliA6NGE7.
SMRiA6NGE7. Positions 2-162.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 885Substrate binding Reviewed prediction
Regioni119 – 1235Substrate binding Reviewed prediction

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi171 – 1733Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3195.
HOGENOMiHOG000251764.
HOVERGENiHBG108651.
InParanoidiA6NGE7.
KOiK13485.
OMAiKEGILRC.
OrthoDBiEOG7GFB6D.
PhylomeDBiA6NGE7.
TreeFamiTF323276.

Family and domain databases

Gene3Di1.10.3330.10. 1 hit.
InterProiIPR018020. OHCU_decarboxylase.
IPR017580. OHCU_decarboxylase-1.
[Graphical view]
PfamiPF09349. OHCU_decarbox. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03164. UHCUDC. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NGE7-1 [UniParc]FASTAAdd to Basket

« Hide

MDIEKVNSMD LGEFVDVFGN ATERCPLIAA AVWSQRPFSD LEDLEKHFFA    50
FIDALAQSGQ EGILRCHPDL AGSELQRGTL TAESQREQSG AGLRSLGADE 100
RLRLAELNAQ YRARFGFPFV LAARFSDRTA VPRELARRLL CPSAQELRTA 150
LGEVKKIGSL RLADLLRADP AKL 173
Length:173
Mass (Da):19,130
Last modified:January 15, 2008 - v2
Checksum:i521C44BEF163077C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571Q → P.
Corresponds to variant rs3897926 [ dbSNP | Ensembl ].
VAR_053987

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591024 Genomic DNA. No translation available.
CCDSiCCDS45020.1.
RefSeqiNP_001099047.1. NM_001105577.1.
UniGeneiHs.705356.

Genome annotation databases

EnsembliENST00000332715; ENSP00000333490; ENSG00000183463.
GeneIDi646625.
KEGGihsa:646625.
UCSCiuc010aan.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591024 Genomic DNA. No translation available.
CCDSi CCDS45020.1.
RefSeqi NP_001099047.1. NM_001105577.1.
UniGenei Hs.705356.

3D structure databases

ProteinModelPortali A6NGE7.
SMRi A6NGE7. Positions 2-162.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000333490.

PTM databases

PhosphoSitei A6NGE7.

Proteomic databases

PaxDbi A6NGE7.
PRIDEi A6NGE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332715 ; ENSP00000333490 ; ENSG00000183463 .
GeneIDi 646625.
KEGGi hsa:646625.
UCSCi uc010aan.1. human.

Organism-specific databases

CTDi 646625.
GeneCardsi GC13M028555.
HGNCi HGNC:17785. URAD.
HPAi HPA038972.
MIMi 615804. gene.
neXtProti NX_A6NGE7.
PharmGKBi PA142671135.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3195.
HOGENOMi HOG000251764.
HOVERGENi HBG108651.
InParanoidi A6NGE7.
KOi K13485.
OMAi KEGILRC.
OrthoDBi EOG7GFB6D.
PhylomeDBi A6NGE7.
TreeFami TF323276.

Enzyme and pathway databases

UniPathwayi UPA00394 ; UER00652 .

Miscellaneous databases

NextBioi 119115.
PROi A6NGE7.
SOURCEi Search...

Gene expression databases

CleanExi HS_PRHOXNB.
Genevestigatori A6NGE7.

Family and domain databases

Gene3Di 1.10.3330.10. 1 hit.
InterProi IPR018020. OHCU_decarboxylase.
IPR017580. OHCU_decarboxylase-1.
[Graphical view ]
Pfami PF09349. OHCU_decarbox. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03164. UHCUDC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes."
    Ramazzina I., Folli C., Secchi A., Berni R., Percudani R.
    Nat. Chem. Biol. 2:144-148(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF TISSUE SPECIFICITY.

Entry informationi

Entry nameiURAD_HUMAN
AccessioniPrimary (citable) accession number: A6NGE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. In primates the genes coding for the enzymes for the degradation of uric acid were inactivated and converted to pseudogenes (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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