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A6NGE7

- URAD_HUMAN

UniProt

A6NGE7 - URAD_HUMAN

Protein

Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Gene

URAD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Protein uncertaini
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.Curated

    Catalytic activityi

    5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Proton donorSequence Analysis
    Binding sitei68 – 681Substrate; via carbonyl oxygenSequence Analysis

    GO - Molecular functioni

    1. carboxy-lyase activity Source: UniProtKB

    GO - Biological processi

    1. allantoin biosynthetic process Source: InterPro
    2. purine nucleobase metabolic process Source: UniProtKB-KW
    3. urate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Purine metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00394; UER00652.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (EC:4.1.1.97)
    Short name:
    OHCU decarboxylase
    Alternative name(s):
    Parahox neighbor
    Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
    Gene namesi
    Name:URAD
    Synonyms:PRHOXNB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:17785. URAD.

    Subcellular locationi

    Peroxisome Curated

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671135.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 173173Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylasePRO_0000315240Add
    BLAST

    Proteomic databases

    PaxDbiA6NGE7.
    PRIDEiA6NGE7.

    PTM databases

    PhosphoSiteiA6NGE7.

    Expressioni

    Tissue specificityi

    Apparently not expressed.

    Gene expression databases

    CleanExiHS_PRHOXNB.
    GenevestigatoriA6NGE7.

    Organism-specific databases

    HPAiHPA038972.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333490.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NGE7.
    SMRiA6NGE7. Positions 2-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 885Substrate bindingSequence Analysis
    Regioni119 – 1235Substrate bindingSequence Analysis

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi171 – 1733Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Belongs to the OHCU decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG3195.
    HOGENOMiHOG000251764.
    HOVERGENiHBG108651.
    InParanoidiA6NGE7.
    KOiK13485.
    OMAiKEGILRC.
    OrthoDBiEOG7GFB6D.
    PhylomeDBiA6NGE7.
    TreeFamiTF323276.

    Family and domain databases

    Gene3Di1.10.3330.10. 1 hit.
    InterProiIPR018020. OHCU_decarboxylase.
    IPR017580. OHCU_decarboxylase-1.
    [Graphical view]
    PfamiPF09349. OHCU_decarbox. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03164. UHCUDC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6NGE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIEKVNSMD LGEFVDVFGN ATERCPLIAA AVWSQRPFSD LEDLEKHFFA    50
    FIDALAQSGQ EGILRCHPDL AGSELQRGTL TAESQREQSG AGLRSLGADE 100
    RLRLAELNAQ YRARFGFPFV LAARFSDRTA VPRELARRLL CPSAQELRTA 150
    LGEVKKIGSL RLADLLRADP AKL 173
    Length:173
    Mass (Da):19,130
    Last modified:January 15, 2008 - v2
    Checksum:i521C44BEF163077C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571Q → P.
    Corresponds to variant rs3897926 [ dbSNP | Ensembl ].
    VAR_053987

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591024 Genomic DNA. No translation available.
    CCDSiCCDS45020.1.
    RefSeqiNP_001099047.1. NM_001105577.1.
    UniGeneiHs.705356.

    Genome annotation databases

    EnsembliENST00000332715; ENSP00000333490; ENSG00000183463.
    GeneIDi646625.
    KEGGihsa:646625.
    UCSCiuc010aan.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591024 Genomic DNA. No translation available.
    CCDSi CCDS45020.1.
    RefSeqi NP_001099047.1. NM_001105577.1.
    UniGenei Hs.705356.

    3D structure databases

    ProteinModelPortali A6NGE7.
    SMRi A6NGE7. Positions 2-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333490.

    PTM databases

    PhosphoSitei A6NGE7.

    Proteomic databases

    PaxDbi A6NGE7.
    PRIDEi A6NGE7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332715 ; ENSP00000333490 ; ENSG00000183463 .
    GeneIDi 646625.
    KEGGi hsa:646625.
    UCSCi uc010aan.1. human.

    Organism-specific databases

    CTDi 646625.
    GeneCardsi GC13M028555.
    HGNCi HGNC:17785. URAD.
    HPAi HPA038972.
    MIMi 615804. gene.
    neXtProti NX_A6NGE7.
    PharmGKBi PA142671135.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3195.
    HOGENOMi HOG000251764.
    HOVERGENi HBG108651.
    InParanoidi A6NGE7.
    KOi K13485.
    OMAi KEGILRC.
    OrthoDBi EOG7GFB6D.
    PhylomeDBi A6NGE7.
    TreeFami TF323276.

    Enzyme and pathway databases

    UniPathwayi UPA00394 ; UER00652 .

    Miscellaneous databases

    NextBioi 119115.
    PROi A6NGE7.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_PRHOXNB.
    Genevestigatori A6NGE7.

    Family and domain databases

    Gene3Di 1.10.3330.10. 1 hit.
    InterProi IPR018020. OHCU_decarboxylase.
    IPR017580. OHCU_decarboxylase-1.
    [Graphical view ]
    Pfami PF09349. OHCU_decarbox. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03164. UHCUDC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes."
      Ramazzina I., Folli C., Secchi A., Berni R., Percudani R.
      Nat. Chem. Biol. 2:144-148(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiURAD_HUMAN
    AccessioniPrimary (citable) accession number: A6NGE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. In primates the genes coding for the enzymes for the degradation of uric acid were inactivated and converted to pseudogenes (PubMed:16462750).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3