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Protein

DDB1- and CUL4-associated factor 8-like protein 1

Gene

DCAF8L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32643-MONOMER.
SignaLinkiA6NGE4.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 8-like protein 1
Alternative name(s):
WD repeat-containing protein 42B
Gene namesi
Name:DCAF8L1
Synonyms:WDR42B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:31810. DCAF8L1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi139425.
OpenTargetsiENSG00000226372.
PharmGKBiPA165756552.

Polymorphism and mutation databases

BioMutaiDCAF8L1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148201 – 600DDB1- and CUL4-associated factor 8-like protein 1Add BLAST600

Proteomic databases

MaxQBiA6NGE4.
PaxDbiA6NGE4.
PRIDEiA6NGE4.

PTM databases

iPTMnetiA6NGE4.
PhosphoSitePlusiA6NGE4.

Expressioni

Gene expression databases

BgeeiENSG00000226372.
CleanExiHS_WDR42B.

Organism-specific databases

HPAiHPA043787.

Interactioni

Protein-protein interaction databases

BioGridi126567. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA6NGE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati194 – 233WD 1Add BLAST40
Repeati237 – 278WD 2Add BLAST42
Repeati284 – 324WD 3Add BLAST41
Repeati332 – 372WD 4Add BLAST41
Repeati388 – 427WD 5Add BLAST40
Repeati435 – 475WD 6Add BLAST41
Repeati479 – 518WD 7Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 115Glu-richAdd BLAST43

Sequence similaritiesi

Belongs to the WD repeat DCAF8 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000243561.
HOVERGENiHBG053807.
InParanoidiA6NGE4.
OMAiISMNPAN.
OrthoDBiEOG091G056C.
PhylomeDBiA6NGE4.
TreeFamiTF326071.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NGE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQEGSTGG LPDLVTESLF SSPEEQSGVA AVTAASSDIE MAATEPSTGD
60 70 80 90 100
GGDTRDGGFL NDASTENQNT DSESSSEDVE LESMGEGLFG YPLVGEETER
110 120 130 140 150
EEEEEEMEEE GEEEEQPRMC PRCGGTNHDQ CLLDEDQALE EWISSETSAL
160 170 180 190 200
PRSRWQVLTA LRQRQLGSSA RFVYEACGAR TFVQRFRLQY LLGSHAGSVS
210 220 230 240 250
TIHFNQRGTR LASSGDDLRV IVWDWVRQKP VLNFESGHDI NVIQAKFFPN
260 270 280 290 300
CGDSTLAMCG HDGQVRVAEL INASYCENTK RVAKHRGPAH ELALEPDSPY
310 320 330 340 350
KFLTSGEDAV VFTIDLRQDR PASKVVVTRE NDKKVGLYTI SMNPANIYQF
360 370 380 390 400
AVGGHDQFVR IYDQRRIDKK ENNGVLKKFT PHHLVYCDFP TNITCVVYSH
410 420 430 440 450
DGTELLASYN DEDIYLFNSS LSDGAQYVKR YKGHRNNDTI KCVNFYGPRS
460 470 480 490 500
EFVVSGSDCG HVFFWEKSSS QIIQFMEGDR GDIVNCLEPH PYLPVLATSG
510 520 530 540 550
LDQHVRIWTP TAKTATELTG LKDVIKKNKQ ERDEDNLNYT DSFDNRMLRF
560 570 580 590 600
FVRHLLQRAH QPGWRDHGAE FPDEEELDES SSTSDTSEEE GQDRVQCIPS
Length:600
Mass (Da):67,373
Last modified:July 24, 2007 - v1
Checksum:iDB74F2E7A625C6C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038060549R → W.Corresponds to variant rs12388557dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128123 mRNA. Translation: BAG54633.1.
AC004553 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW99044.1.
CCDSiCCDS35222.1.
RefSeqiNP_001017930.1. NM_001017930.1.
UniGeneiHs.447365.

Genome annotation databases

EnsembliENST00000441525; ENSP00000405222; ENSG00000226372.
GeneIDi139425.
KEGGihsa:139425.
UCSCiuc004dbx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128123 mRNA. Translation: BAG54633.1.
AC004553 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW99044.1.
CCDSiCCDS35222.1.
RefSeqiNP_001017930.1. NM_001017930.1.
UniGeneiHs.447365.

3D structure databases

ProteinModelPortaliA6NGE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126567. 1 interactor.

PTM databases

iPTMnetiA6NGE4.
PhosphoSitePlusiA6NGE4.

Polymorphism and mutation databases

BioMutaiDCAF8L1.

Proteomic databases

MaxQBiA6NGE4.
PaxDbiA6NGE4.
PRIDEiA6NGE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000441525; ENSP00000405222; ENSG00000226372.
GeneIDi139425.
KEGGihsa:139425.
UCSCiuc004dbx.2. human.

Organism-specific databases

CTDi139425.
DisGeNETi139425.
GeneCardsiDCAF8L1.
HGNCiHGNC:31810. DCAF8L1.
HPAiHPA043787.
neXtProtiNX_A6NGE4.
OpenTargetsiENSG00000226372.
PharmGKBiPA165756552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000243561.
HOVERGENiHBG053807.
InParanoidiA6NGE4.
OMAiISMNPAN.
OrthoDBiEOG091G056C.
PhylomeDBiA6NGE4.
TreeFamiTF326071.

Enzyme and pathway databases

BioCyciZFISH:G66-32643-MONOMER.
SignaLinkiA6NGE4.

Miscellaneous databases

GenomeRNAii139425.
PROiA6NGE4.

Gene expression databases

BgeeiENSG00000226372.
CleanExiHS_WDR42B.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDC8L1_HUMAN
AccessioniPrimary (citable) accession number: A6NGE4
Secondary accession number(s): B3KXX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.