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Protein

Putative zinc finger and SCAN domain-containing protein 5C

Gene

ZSCAN5CP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri356 – 37823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger and SCAN domain-containing protein 5CImported
Alternative name(s):
Zinc finger and SCAN domain-containing protein 5C pseudogeneImported
Gene namesi
Name:ZSCAN5CPImported
Synonyms:ZSCAN5C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34294. ZSCAN5CP.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162411044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Putative zinc finger and SCAN domain-containing protein 5CPRO_0000332170Add
BLAST

Proteomic databases

EPDiA6NGD5.
PaxDbiA6NGD5.
PRIDEiA6NGD5.

PTM databases

iPTMnetiA6NGD5.
PhosphoSiteiA6NGD5.

Expressioni

Gene expression databases

BgeeiA6NGD5.

Organism-specific databases

HPAiHPA041263.
HPA043123.
HPA046836.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365443.

Structurei

3D structure databases

ProteinModelPortaliA6NGD5.
SMRiA6NGD5. Positions 40-97, 355-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12683SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri356 – 37823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00710000106788.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiA6NGD5.
OMAiATQLGNH.
OrthoDBiEOG78PV8X.
PhylomeDBiA6NGD5.
TreeFamiTF341155.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NGD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANCTSSWS LGESCNSPGS EPPQSMPSPA TQLGNHDSDP ETCHVNFRMF
60 70 80 90 100
SCPKESDPIQ ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL
110 120 130 140 150
QVLVMMNGVQ SCKDLEDLLR NNRRPKKWSV VSFLGKEYLM QESDVEMAEA
160 170 180 190 200
PASVRDDPRH VSSQRTSSVN QMCPEEGQAS QELQTLPRVP ALFRRQEEDF
210 220 230 240 250
LLPETTVMKG DPKALRPKPT LEKDLEEDRE ENPGLTSPEP QLPNSPTGVV
260 270 280 290 300
GAKEGKEPQK RASVENVDAD TPSACVVERE ASTHSGSRGD ALNLRGLKRS
310 320 330 340 350
KPDATSISQE EPQGEATPVG NRESPGQAEI NPVHSPGPAG PVSHPSGQEV
360 370 380 390 400
KELLPFACEV CGKRFKYRGK LAVHTRSHTG ERLFQCNLCG KRFMQRIGLQ
410 420 430 440 450
FHQRTHTGER PYTCDICQKQ FTQKSYLKCH KRSHTGEKPF ECKDCKKVFT
460 470 480 490
YKANLKEHQR IHSGEKPHKC SKCPRAFGRP ATLRRHQKTH REATSQ
Length:496
Mass (Da):55,729
Last modified:July 24, 2007 - v1
Checksum:iE677765AEDE42466
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241Q → R.
Corresponds to variant rs10419548 [ dbSNP | Ensembl ].
VAR_052927
Natural varianti181 – 1811Q → R.
Corresponds to variant rs4801690 [ dbSNP | Ensembl ].
VAR_042970
Natural varianti197 – 1971E → D.
Corresponds to variant rs12979551 [ dbSNP | Ensembl ].
VAR_042971
Natural varianti259 – 2591Q → K.
Corresponds to variant rs1865102 [ dbSNP | Ensembl ].
VAR_052928

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011506 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000376267; ENSP00000365443; ENSG00000204532.
ENST00000534327; ENSP00000435234; ENSG00000204532.
UCSCiuc061dec.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011506 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA6NGD5.
SMRiA6NGD5. Positions 40-97, 355-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365443.

PTM databases

iPTMnetiA6NGD5.
PhosphoSiteiA6NGD5.

Proteomic databases

EPDiA6NGD5.
PaxDbiA6NGD5.
PRIDEiA6NGD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376267; ENSP00000365443; ENSG00000204532.
ENST00000534327; ENSP00000435234; ENSG00000204532.
UCSCiuc061dec.1. human.

Organism-specific databases

GeneCardsiZSCAN5C.
HGNCiHGNC:34294. ZSCAN5CP.
HPAiHPA041263.
HPA043123.
HPA046836.
neXtProtiNX_A6NGD5.
PharmGKBiPA162411044.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00710000106788.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiA6NGD5.
OMAiATQLGNH.
OrthoDBiEOG78PV8X.
PhylomeDBiA6NGD5.
TreeFamiTF341155.

Miscellaneous databases

PROiA6NGD5.

Gene expression databases

BgeeiA6NGD5.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZSA5C_HUMAN
AccessioniPrimary (citable) accession number: A6NGD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.