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Protein

TLC domain-containing protein 2

Gene

TLCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
TLC domain-containing protein 2
Gene namesi
Name:TLCD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:33522. TLCD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405795.

Polymorphism and mutation databases

BioMutaiTLCD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264TLC domain-containing protein 2PRO_0000328990Add
BLAST

Proteomic databases

EPDiA6NGC4.
PaxDbiA6NGC4.
PeptideAtlasiA6NGC4.
PRIDEiA6NGC4.

PTM databases

iPTMnetiA6NGC4.
PhosphoSiteiA6NGC4.

Expressioni

Gene expression databases

BgeeiA6NGC4.
CleanExiHS_TLCD2.
GenevisibleiA6NGC4. HS.

Organism-specific databases

HPAiHPA046063.

Interactioni

Protein-protein interaction databases

BioGridi608350. 3 interactions.
IntActiA6NGC4. 2 interactions.
STRINGi9606.ENSP00000331965.

Structurei

3D structure databases

ProteinModelPortaliA6NGC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 227194TLCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TLCD family.Curated
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4474. Eukaryota.
ENOG410Z5I9. LUCA.
GeneTreeiENSGT00520000055611.
HOGENOMiHOG000015396.
HOVERGENiHBG108573.
InParanoidiA6NGC4.
OMAiNRWKWRN.
OrthoDBiEOG7CK37S.
PhylomeDBiA6NGC4.
TreeFamiTF315115.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NGC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTGLLVAG ASFLAFRGLH WGLRRLPTPE SAARDRWQWW NLCVSLAHSL
60 70 80 90 100
LSGTGALLGL SLYPQMAADP IHGHPRWALV LVAVSVGYFL ADGADLLWNQ
110 120 130 140 150
TLGKTWDLLC HHLVVVSCLS TAVLSGHYVG FSMVSLLLEL NSACLHLRKL
160 170 180 190 200
LLLSRQAPSL AFSVTSWASL ATLALFRLVP LGWMSLWLFR QHHQVPLALV
210 220 230 240 250
TLGGIGLVTV GIMSIILGIR ILVNDVLQSR PHPPSPGHEK TRGTRTRRDN
260
GPVTSNSSTL SLKD
Length:264
Mass (Da):28,733
Last modified:July 22, 2008 - v3
Checksum:iE2B4B93612BCC33A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130343 Genomic DNA. No translation available.
CCDSiCCDS45567.1.
RefSeqiNP_001157879.1. NM_001164407.1.
UniGeneiHs.531005.

Genome annotation databases

EnsembliENST00000330676; ENSP00000331965; ENSG00000185561.
ENST00000611774; ENSP00000479301; ENSG00000275246.
GeneIDi727910.
KEGGihsa:727910.
UCSCiuc021tnh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130343 Genomic DNA. No translation available.
CCDSiCCDS45567.1.
RefSeqiNP_001157879.1. NM_001164407.1.
UniGeneiHs.531005.

3D structure databases

ProteinModelPortaliA6NGC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608350. 3 interactions.
IntActiA6NGC4. 2 interactions.
STRINGi9606.ENSP00000331965.

PTM databases

iPTMnetiA6NGC4.
PhosphoSiteiA6NGC4.

Polymorphism and mutation databases

BioMutaiTLCD2.

Proteomic databases

EPDiA6NGC4.
PaxDbiA6NGC4.
PeptideAtlasiA6NGC4.
PRIDEiA6NGC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330676; ENSP00000331965; ENSG00000185561.
ENST00000611774; ENSP00000479301; ENSG00000275246.
GeneIDi727910.
KEGGihsa:727910.
UCSCiuc021tnh.2. human.

Organism-specific databases

CTDi727910.
GeneCardsiTLCD2.
HGNCiHGNC:33522. TLCD2.
HPAiHPA046063.
neXtProtiNX_A6NGC4.
PharmGKBiPA162405795.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4474. Eukaryota.
ENOG410Z5I9. LUCA.
GeneTreeiENSGT00520000055611.
HOGENOMiHOG000015396.
HOVERGENiHBG108573.
InParanoidiA6NGC4.
OMAiNRWKWRN.
OrthoDBiEOG7CK37S.
PhylomeDBiA6NGC4.
TreeFamiTF315115.

Miscellaneous databases

ChiTaRSiTLCD2. human.
GenomeRNAii727910.
PROiA6NGC4.

Gene expression databases

BgeeiA6NGC4.
CleanExiHS_TLCD2.
GenevisibleiA6NGC4. HS.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTLCD2_HUMAN
AccessioniPrimary (citable) accession number: A6NGC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 22, 2008
Last modified: July 6, 2016
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.