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Protein

WAS/WASL-interacting protein family member 3

Gene

WIPF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
WAS/WASL-interacting protein family member 3
Alternative name(s):
Corticosteroids and regional expression protein 16 homolog
Gene namesi
Name:WIPF3
Synonyms:CR16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22004. WIPF3.

Subcellular locationi

  • Cytoplasm

  • Note: In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409231.

Polymorphism and mutation databases

BioMutaiWIPF3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483WAS/WASL-interacting protein family member 3PRO_0000337997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineCombined sources
Modified residuei202 – 2021PhosphoserineCombined sources
Modified residuei383 – 3831PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA6NGB9.
PRIDEiA6NGB9.

PTM databases

iPTMnetiA6NGB9.
PhosphoSiteiA6NGB9.

Expressioni

Gene expression databases

BgeeiENSG00000122574.
CleanExiHS_WIPF3.
ExpressionAtlasiA6NGB9. baseline and differential.
GenevisibleiA6NGB9. HS.

Organism-specific databases

HPAiHPA041145.
HPA041211.

Interactioni

Subunit structurei

Interacts with WASL, and monomeric and filamentous actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi569353. 4 interactions.
IntActiA6NGB9. 2 interactions.
STRINGi9606.ENSP00000386878.

Structurei

3D structure databases

ProteinModelPortaliA6NGB9.
SMRiA6NGB9. Positions 42-74, 419-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 6218WH2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3 – 86Profilin-binding motif
Motifi11 – 166Profilin-binding motif
Motifi20 – 256Profilin-binding motif
Motifi58 – 614RLRK
Motifi424 – 44825WASP-binding motifAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi172 – 19120Poly-ProAdd
BLAST
Compositional biasi223 – 23917Poly-ProAdd
BLAST
Compositional biasi289 – 29810Poly-Pro

Domaini

The WH2 domain is found in a number of putative actin-binding proteins.By similarity
The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains.By similarity
The KLKR motif is essential for G-actin binding and for actin polymerization.By similarity

Sequence similaritiesi

Belongs to the verprolin family.Curated
Contains 1 WH2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J09R. Eukaryota.
ENOG410Y0AH. LUCA.
GeneTreeiENSGT00840000129980.
HOGENOMiHOG000090003.
HOVERGENiHBG108677.
InParanoidiA6NGB9.
KOiK19475.
OrthoDBiEOG091G0GSL.
PhylomeDBiA6NGB9.

Family and domain databases

InterProiIPR003124. WH2_dom.
[Graphical view]
PfamiPF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NGB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVPPPPPPP LPPPPPPLGA PPPPPPSAPP VSTDTSSLRR ADPKGRSALL
60 70 80 90 100
ADIQQGTRLR KVTQINDRSA PQIESSKGTN KEGGGSANTR GASTPPTLGD
110 120 130 140 150
LFAGGFPVLR PAGQRDVAGG KTGQGPGSRA PSPRLPNKTI SGPLIPPASP
160 170 180 190 200
RLGNTSEAHG AARTAPPRPN VPAPPPPTPP PPPPPLPPPL PSSSPIKTPL
210 220 230 240 250
VSPPGPLTKG NLPVVAPPVP CAPPPPPPPP PPTPPPLPPA SVLSDKAVKP
260 270 280 290 300
QLAPLHLPPI PPPLPLLPPC GYPGLKAEPA SPAQDAQEPP APPPPLPPYA
310 320 330 340 350
SCSPRASLPA PPLPGVNSSS ETPPPLPPKS PSFQAPPQKA GAQALPAPPA
360 370 380 390 400
PPGSQPFLQK KRHGRPGAGG GKLNPPPAPP ARSPTTELSS KSQQATAWTP
410 420 430 440 450
TQQPGGQLRN GSLHIIDDFE SKFTFHSVED FPPPDEYKPC QKIYPSKIPR
460 470 480
SRTPGPWLQA EAVGQSSDDI KGRNSQLSLK TLR
Length:483
Mass (Da):49,458
Last modified:June 26, 2013 - v4
Checksum:i78A600C2FE4F9CCE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti321 – 3211E → G.
Corresponds to variant rs3750092 [ dbSNP | Ensembl ].
VAR_043729

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004912 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93924.1.
BX107905 mRNA. No translation available.
CCDSiCCDS56472.1.
RefSeqiNP_001073998.2. NM_001080529.2.
UniGeneiHs.380698.

Genome annotation databases

EnsembliENST00000242140; ENSP00000242140; ENSG00000122574.
ENST00000409290; ENSP00000386878; ENSG00000122574.
GeneIDi644150.
KEGGihsa:644150.
UCSCiuc022aaz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004912 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93924.1.
BX107905 mRNA. No translation available.
CCDSiCCDS56472.1.
RefSeqiNP_001073998.2. NM_001080529.2.
UniGeneiHs.380698.

3D structure databases

ProteinModelPortaliA6NGB9.
SMRiA6NGB9. Positions 42-74, 419-460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi569353. 4 interactions.
IntActiA6NGB9. 2 interactions.
STRINGi9606.ENSP00000386878.

PTM databases

iPTMnetiA6NGB9.
PhosphoSiteiA6NGB9.

Polymorphism and mutation databases

BioMutaiWIPF3.

Proteomic databases

PaxDbiA6NGB9.
PRIDEiA6NGB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242140; ENSP00000242140; ENSG00000122574.
ENST00000409290; ENSP00000386878; ENSG00000122574.
GeneIDi644150.
KEGGihsa:644150.
UCSCiuc022aaz.1. human.

Organism-specific databases

CTDi644150.
GeneCardsiWIPF3.
H-InvDBHIX0020239.
HGNCiHGNC:22004. WIPF3.
HPAiHPA041145.
HPA041211.
MIMi612432. gene.
neXtProtiNX_A6NGB9.
PharmGKBiPA162409231.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J09R. Eukaryota.
ENOG410Y0AH. LUCA.
GeneTreeiENSGT00840000129980.
HOGENOMiHOG000090003.
HOVERGENiHBG108677.
InParanoidiA6NGB9.
KOiK19475.
OrthoDBiEOG091G0GSL.
PhylomeDBiA6NGB9.

Enzyme and pathway databases

ReactomeiR-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

ChiTaRSiWIPF3. human.
GenomeRNAii644150.
PROiA6NGB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122574.
CleanExiHS_WIPF3.
ExpressionAtlasiA6NGB9. baseline and differential.
GenevisibleiA6NGB9. HS.

Family and domain databases

InterProiIPR003124. WH2_dom.
[Graphical view]
PfamiPF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWIPF3_HUMAN
AccessioniPrimary (citable) accession number: A6NGB9
Secondary accession number(s): B8ZZV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 26, 2013
Last modified: September 7, 2016
This is version 81 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.