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Protein

Transmembrane protein 202

Gene

TMEM202

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 202
Gene namesi
Name:TMEM202
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:33733. TMEM202.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7523HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Transmembrane protein 202PRO_0000317201Add
BLAST

Proteomic databases

PaxDbiA6NGA9.
PRIDEiA6NGA9.

PTM databases

PhosphoSiteiA6NGA9.

Expressioni

Gene expression databases

BgeeiA6NGA9.
CleanExiHS_TMEM202.
GenevestigatoriA6NGA9.

Organism-specific databases

HPAiHPA049035.

Structurei

3D structure databases

ProteinModelPortaliA6NGA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40198.
GeneTreeiENSGT00390000006869.
HOGENOMiHOG000090211.
HOVERGENiHBG094967.
InParanoidiA6NGA9.
OMAiWSHTPKP.
OrthoDBiEOG74N5HH.
PhylomeDBiA6NGA9.
TreeFamiTF337324.

Sequencei

Sequence statusi: Complete.

A6NGA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERREHLTLT FHSPEVPKIK GNRKYQRPTV PAKKHPSASM SCQRQQQLMD
60 70 80 90 100
QAHIYIRTLC GSLCSFSLLM LIAMSPLNWV QFLVIKNGLE LYAGLWTLCN
110 120 130 140 150
HELCWSHTPK PPYYLQYSRA FFLISVFTIL TGLGWLFSSW ILNRGSMTTN
160 170 180 190 200
LDLKVSMLSF ISATCLLLCL NLFVAQVHWH TRDAMESDLL WTYYLNWCSD
210 220 230 240 250
IFYMFAGIIS LLNYLTSRSP ACDENVTVIP TERSRLGVGP VTTVSPAKDE
260 270
GPRSEMESLS VREKNLPKSG LWW
Length:273
Mass (Da):31,353
Last modified:July 24, 2007 - v1
Checksum:i7912F1A665B28424
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti204 – 2041M → L.
Corresponds to variant rs16956904 [ dbSNP | Ensembl ].
VAR_051434

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079322 Genomic DNA. No translation available.
CCDSiCCDS32287.1.
RefSeqiNP_001073931.1. NM_001080462.1.
UniGeneiHs.446069.

Genome annotation databases

EnsembliENST00000341689; ENSP00000340212; ENSG00000187806.
GeneIDi338949.
KEGGihsa:338949.
UCSCiuc002auq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079322 Genomic DNA. No translation available.
CCDSiCCDS32287.1.
RefSeqiNP_001073931.1. NM_001080462.1.
UniGeneiHs.446069.

3D structure databases

ProteinModelPortaliA6NGA9.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA6NGA9.

Proteomic databases

PaxDbiA6NGA9.
PRIDEiA6NGA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341689; ENSP00000340212; ENSG00000187806.
GeneIDi338949.
KEGGihsa:338949.
UCSCiuc002auq.3. human.

Organism-specific databases

CTDi338949.
GeneCardsiGC15P072690.
HGNCiHGNC:33733. TMEM202.
HPAiHPA049035.
neXtProtiNX_A6NGA9.
PharmGKBiPA162406376.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40198.
GeneTreeiENSGT00390000006869.
HOGENOMiHOG000090211.
HOVERGENiHBG094967.
InParanoidiA6NGA9.
OMAiWSHTPKP.
OrthoDBiEOG74N5HH.
PhylomeDBiA6NGA9.
TreeFamiTF337324.

Miscellaneous databases

GenomeRNAii338949.
NextBioi97199.
PROiA6NGA9.

Gene expression databases

BgeeiA6NGA9.
CleanExiHS_TMEM202.
GenevestigatoriA6NGA9.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTM202_HUMAN
AccessioniPrimary (citable) accession number: A6NGA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.