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Protein

Major facilitator superfamily domain-containing protein 2B

Gene

MFSD2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 2B
Gene namesi
Name:MFSD2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:37207. MFSD2B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Transmembranei459 – 47921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165696804.

Polymorphism and mutation databases

BioMutaiMFSD2B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Major facilitator superfamily domain-containing protein 2BPRO_0000341260Add
BLAST

Proteomic databases

PaxDbiA6NFX1.
PeptideAtlasiA6NFX1.
PRIDEiA6NFX1.

PTM databases

iPTMnetiA6NFX1.
PhosphoSiteiA6NFX1.

Expressioni

Gene expression databases

BgeeiA6NFX1.
ExpressionAtlasiA6NFX1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385527.

Structurei

3D structure databases

ProteinModelPortaliA6NFX1.
SMRiA6NFX1. Positions 39-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4830. Eukaryota.
COG2211. LUCA.
GeneTreeiENSGT00390000005318.
HOGENOMiHOG000294186.
HOVERGENiHBG080097.
InParanoidiA6NFX1.
OrthoDBiEOG7QRQTT.
PhylomeDBiA6NFX1.
TreeFamiTF331194.

Family and domain databases

InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NFX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPAPAAK GSPQPEPHAP EPGPGSAKRG REDSRAGRLS FCTKVCYGIG
60 70 80 90 100
GVPNQIASSA TAFYLQLFLL DIAQIPAAQV SLVLFGGKVS GAAADPVAGF
110 120 130 140 150
FINRSQRTGS GRLMPWVLGC TPFIALAYFF LWFLPPFTSL RGLWYTTFYC
160 170 180 190 200
LFQALATFFQ VPYTALTMLL TPCPRERDSA TAYRMTVEMA GTLMGATVHG
210 220 230 240 250
LIVSGAHRPH RCEATATPGP VTVSPNAAHL YCIAAAVVVV TYPVCISLLC
260 270 280 290 300
LGVKERPDPS APASGPGLSF LAGLSLTTRH PPYLKLVISF LFISAAVQVE
310 320 330 340 350
QSYLVLFCTH ASQLHDHVQG LVLTVLVSAV LSTPLWEWVL QRFGKKTSAF
360 370 380 390 400
GIFAMVPFAI LLAAVPTAPV AYVVAFVSGV SIAVSLLLPW SMLPDVVDDF
410 420 430 440 450
QLQHRHGPGL ETIFYSSYVF FTKLSGACAL GISTLSLEFS GYKAGVCKQA
460 470 480 490
EEVVVTLKVL IGAVPTCMIL AGLCILMVGS TPKTPSRDAS SRLSLRR
Length:497
Mass (Da):52,964
Last modified:June 15, 2010 - v3
Checksum:iE87AC394084517D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104665 Genomic DNA. No translation available.
BX357394 mRNA. No translation available.
CCDSiCCDS46228.1.
RefSeqiNP_001073942.1. NM_001080473.1.
UniGeneiHs.407482.

Genome annotation databases

EnsembliENST00000406420; ENSP00000385527; ENSG00000205639.
GeneIDi388931.
KEGGihsa:388931.
UCSCiuc032ngs.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104665 Genomic DNA. No translation available.
BX357394 mRNA. No translation available.
CCDSiCCDS46228.1.
RefSeqiNP_001073942.1. NM_001080473.1.
UniGeneiHs.407482.

3D structure databases

ProteinModelPortaliA6NFX1.
SMRiA6NFX1. Positions 39-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000385527.

PTM databases

iPTMnetiA6NFX1.
PhosphoSiteiA6NFX1.

Polymorphism and mutation databases

BioMutaiMFSD2B.

Proteomic databases

PaxDbiA6NFX1.
PeptideAtlasiA6NFX1.
PRIDEiA6NFX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000406420; ENSP00000385527; ENSG00000205639.
GeneIDi388931.
KEGGihsa:388931.
UCSCiuc032ngs.2. human.

Organism-specific databases

CTDi388931.
GeneCardsiMFSD2B.
HGNCiHGNC:37207. MFSD2B.
neXtProtiNX_A6NFX1.
PharmGKBiPA165696804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4830. Eukaryota.
COG2211. LUCA.
GeneTreeiENSGT00390000005318.
HOGENOMiHOG000294186.
HOVERGENiHBG080097.
InParanoidiA6NFX1.
OrthoDBiEOG7QRQTT.
PhylomeDBiA6NFX1.
TreeFamiTF331194.

Miscellaneous databases

GenomeRNAii388931.
PROiA6NFX1.

Gene expression databases

BgeeiA6NFX1.
ExpressionAtlasiA6NFX1. baseline and differential.

Family and domain databases

InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-271.
    Tissue: Placenta.
  3. "Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis."
    Angers M., Uldry M., Kong D., Gimble J.M., Jetten A.M.
    Biochem. J. 416:347-355(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMFS2B_HUMAN
AccessioniPrimary (citable) accession number: A6NFX1
Secondary accession number(s): B5MC32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 15, 2010
Last modified: July 6, 2016
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.