Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6NFU0 (F187A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig-like V-type domain-containing protein FAM187A
Gene names
Name:FAM187A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the FAM187 family.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 413396Ig-like V-type domain-containing protein FAM187A
PRO_0000340654

Regions

Topological domain18 – 376359Extracellular Potential
Transmembrane377 – 39721Helical; Potential
Topological domain398 – 41316Cytoplasmic Potential
Domain267 – 36195Ig-like V-type
Compositional bias398 – 40811Cys-rich

Amino acid modifications

Glycosylation3171N-linked (GlcNAc...) Potential
Disulfide bond289 ↔ 345 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6NFU0 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 580178965D3F9631

FASTA41347,349
        10         20         30         40         50         60 
MHLALTTVLL WAWGLQAFEI VEKENIFQRT PCPAFLMFEN AAYLADMSFE LPCHCKPEEV 

        70         80         90        100        110        120 
PAVVWFYQKH LGSSHTKVLT DFDGRVLTEA AQVRVGSDML TRFSIRMFSL LVFRAQSEDS 

       130        140        150        160        170        180 
GLYFCGTRKG DYFYAYDVDI QNSEGMVATF QDKGQEPFAD EYYGHLHVFT TFWEWTPCDR 

       190        200        210        220        230        240 
CGVRGEQWRI GLCYLQSPDL SPRYLKAVPD VVSCGSRAVP RKLRTKARDH TPEVLVRSCL 

       250        260        270        280        290        300 
VPCEKTKTIR EGVLAIINYV SKVGSRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW 

       310        320        330        340        350        360 
DKDRQHLYRT QYLKGVNRSM RVFIDHGNQL HIRFTQLDDR GIYYCWRQGV LVAGFRLGVT 

       370        380        390        400        410 
SHGHYPASFS DPETRSAVEL TLIGYLLITA VFVTIHFCRC CCYLFHCCPS FSP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC015936 Genomic DNA. No translation available.
UniGeneHs.743398.

3D structure databases

ProteinModelPortalA6NFU0.
SMRA6NFU0. Positions 44-130, 277-359.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbA6NFU0.
PRIDEA6NFU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331733; ENSP00000329499; ENSG00000214447.
ENST00000412523; ENSP00000391869; ENSG00000214447.
KEGGhsa:388389.
UCSCuc002ihp.1. human.

Organism-specific databases

CTD388389.
GeneCardsGC17P042979.
HGNCHGNC:35153. FAM187A.
HPAHPA022794.
neXtProtNX_A6NFU0.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72316.
HOGENOMHOG000155662.
HOVERGENHBG108742.
InParanoidA6NFU0.
OMASMRVFID.
OrthoDBEOG751NFT.
PhylomeDBA6NFU0.
TreeFamTF332178.

Gene expression databases

GenevestigatorA6NFU0.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi388389.
PROA6NFU0.

Entry information

Entry nameF187A_HUMAN
AccessionPrimary (citable) accession number: A6NFU0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM