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Protein

Ig-like V-type domain-containing protein FAM187A

Gene

FAM187A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Ig-like V-type domain-containing protein FAM187A
Gene namesi
Name:FAM187A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:35153. FAM187A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 376ExtracellularSequence analysisAdd BLAST359
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 413CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000034065418 – 413Ig-like V-type domain-containing protein FAM187AAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi289 ↔ 345PROSITE-ProRule annotation
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NFU0.
PRIDEiA6NFU0.

Expressioni

Gene expression databases

GenevisibleiA6NFU0. HS.

Organism-specific databases

HPAiHPA022794.

Structurei

3D structure databases

ProteinModelPortaliA6NFU0.
SMRiA6NFU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 361Ig-like V-typeAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi398 – 408Cys-richAdd BLAST11

Sequence similaritiesi

Belongs to the FAM187 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE2U. Eukaryota.
ENOG410XNRD. LUCA.
GeneTreeiENSGT00390000004038.
HOGENOMiHOG000155662.
HOVERGENiHBG108742.
InParanoidiA6NFU0.
OMAiSMRVFID.
OrthoDBiEOG091G07MV.
PhylomeDBiA6NFU0.
TreeFamiTF332178.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NFU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLALTTVLL WAWGLQAFEI VEKENIFQRT PCPAFLMFEN AAYLADMSFE
60 70 80 90 100
LPCHCKPEEV PAVVWFYQKH LGSSHTKVLT DFDGRVLTEA AQVRVGSDML
110 120 130 140 150
TRFSIRMFSL LVFRAQSEDS GLYFCGTRKG DYFYAYDVDI QNSEGMVATF
160 170 180 190 200
QDKGQEPFAD EYYGHLHVFT TFWEWTPCDR CGVRGEQWRI GLCYLQSPDL
210 220 230 240 250
SPRYLKAVPD VVSCGSRAVP RKLRTKARDH TPEVLVRSCL VPCEKTKTIR
260 270 280 290 300
EGVLAIINYV SKVGSRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW
310 320 330 340 350
DKDRQHLYRT QYLKGVNRSM RVFIDHGNQL HIRFTQLDDR GIYYCWRQGV
360 370 380 390 400
LVAGFRLGVT SHGHYPASFS DPETRSAVEL TLIGYLLITA VFVTIHFCRC
410
CCYLFHCCPS FSP
Length:413
Mass (Da):47,349
Last modified:July 24, 2007 - v1
Checksum:i580178965D3F9631
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015936 Genomic DNA. No translation available.
UniGeneiHs.743398.

Genome annotation databases

EnsembliENST00000331733; ENSP00000329499; ENSG00000214447.
UCSCiuc002ihp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015936 Genomic DNA. No translation available.
UniGeneiHs.743398.

3D structure databases

ProteinModelPortaliA6NFU0.
SMRiA6NFU0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA6NFU0.
PRIDEiA6NFU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331733; ENSP00000329499; ENSG00000214447.
UCSCiuc002ihp.2. human.

Organism-specific databases

GeneCardsiFAM187A.
HGNCiHGNC:35153. FAM187A.
HPAiHPA022794.
neXtProtiNX_A6NFU0.
OpenTargetsiENSG00000214447.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE2U. Eukaryota.
ENOG410XNRD. LUCA.
GeneTreeiENSGT00390000004038.
HOGENOMiHOG000155662.
HOVERGENiHBG108742.
InParanoidiA6NFU0.
OMAiSMRVFID.
OrthoDBiEOG091G07MV.
PhylomeDBiA6NFU0.
TreeFamiTF332178.

Miscellaneous databases

PROiA6NFU0.

Gene expression databases

GenevisibleiA6NFU0. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF187A_HUMAN
AccessioniPrimary (citable) accession number: A6NFU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.