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A6NFU0

- F187A_HUMAN

UniProt

A6NFU0 - F187A_HUMAN

Protein

Ig-like V-type domain-containing protein FAM187A

Gene

FAM187A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig-like V-type domain-containing protein FAM187A
    Gene namesi
    Name:FAM187A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:35153. FAM187A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 413396Ig-like V-type domain-containing protein FAM187APRO_0000340654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi289 ↔ 345PROSITE-ProRule annotation
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiA6NFU0.
    PRIDEiA6NFU0.

    Expressioni

    Gene expression databases

    GenevestigatoriA6NFU0.

    Organism-specific databases

    HPAiHPA022794.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NFU0.
    SMRiA6NFU0. Positions 46-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 376359ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini398 – 41316CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini267 – 36195Ig-like V-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi398 – 40811Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAM187 family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72316.
    HOGENOMiHOG000155662.
    HOVERGENiHBG108742.
    InParanoidiA6NFU0.
    OMAiSMRVFID.
    OrthoDBiEOG751NFT.
    PhylomeDBiA6NFU0.
    TreeFamiTF332178.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6NFU0-1 [UniParc]FASTAAdd to Basket

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    MHLALTTVLL WAWGLQAFEI VEKENIFQRT PCPAFLMFEN AAYLADMSFE    50
    LPCHCKPEEV PAVVWFYQKH LGSSHTKVLT DFDGRVLTEA AQVRVGSDML 100
    TRFSIRMFSL LVFRAQSEDS GLYFCGTRKG DYFYAYDVDI QNSEGMVATF 150
    QDKGQEPFAD EYYGHLHVFT TFWEWTPCDR CGVRGEQWRI GLCYLQSPDL 200
    SPRYLKAVPD VVSCGSRAVP RKLRTKARDH TPEVLVRSCL VPCEKTKTIR 250
    EGVLAIINYV SKVGSRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW 300
    DKDRQHLYRT QYLKGVNRSM RVFIDHGNQL HIRFTQLDDR GIYYCWRQGV 350
    LVAGFRLGVT SHGHYPASFS DPETRSAVEL TLIGYLLITA VFVTIHFCRC 400
    CCYLFHCCPS FSP 413
    Length:413
    Mass (Da):47,349
    Last modified:July 24, 2007 - v1
    Checksum:i580178965D3F9631
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC015936 Genomic DNA. No translation available.
    UniGeneiHs.743398.

    Genome annotation databases

    EnsembliENST00000331733; ENSP00000329499; ENSG00000214447.
    ENST00000412523; ENSP00000391869; ENSG00000214447.
    UCSCiuc002ihp.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC015936 Genomic DNA. No translation available.
    UniGenei Hs.743398.

    3D structure databases

    ProteinModelPortali A6NFU0.
    SMRi A6NFU0. Positions 46-131.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi A6NFU0.
    PRIDEi A6NFU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331733 ; ENSP00000329499 ; ENSG00000214447 .
    ENST00000412523 ; ENSP00000391869 ; ENSG00000214447 .
    UCSCi uc002ihp.1. human.

    Organism-specific databases

    GeneCardsi GC17P042979.
    HGNCi HGNC:35153. FAM187A.
    HPAi HPA022794.
    neXtProti NX_A6NFU0.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72316.
    HOGENOMi HOG000155662.
    HOVERGENi HBG108742.
    InParanoidi A6NFU0.
    OMAi SMRVFID.
    OrthoDBi EOG751NFT.
    PhylomeDBi A6NFU0.
    TreeFami TF332178.

    Miscellaneous databases

    GenomeRNAii 388389.
    PROi A6NFU0.

    Gene expression databases

    Genevestigatori A6NFU0.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiF187A_HUMAN
    AccessioniPrimary (citable) accession number: A6NFU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3