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A6NFU0

- F187A_HUMAN

UniProt

A6NFU0 - F187A_HUMAN

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Protein

Ig-like V-type domain-containing protein FAM187A

Gene

FAM187A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Ig-like V-type domain-containing protein FAM187A
Gene namesi
Name:FAM187A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:35153. FAM187A.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 413396Ig-like V-type domain-containing protein FAM187APRO_0000340654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi289 ↔ 345PROSITE-ProRule annotation
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NFU0.
PRIDEiA6NFU0.

Expressioni

Gene expression databases

ExpressionAtlasiA6NFU0. baseline.
GenevestigatoriA6NFU0.

Organism-specific databases

HPAiHPA022794.

Structurei

3D structure databases

ProteinModelPortaliA6NFU0.
SMRiA6NFU0. Positions 43-127, 275-361.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 376359ExtracellularSequence AnalysisAdd
BLAST
Topological domaini398 – 41316CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei377 – 39721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini267 – 36195Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi398 – 40811Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM187 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72316.
GeneTreeiENSGT00390000004038.
HOGENOMiHOG000155662.
HOVERGENiHBG108742.
InParanoidiA6NFU0.
OMAiSMRVFID.
OrthoDBiEOG751NFT.
PhylomeDBiA6NFU0.
TreeFamiTF332178.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NFU0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MHLALTTVLL WAWGLQAFEI VEKENIFQRT PCPAFLMFEN AAYLADMSFE
60 70 80 90 100
LPCHCKPEEV PAVVWFYQKH LGSSHTKVLT DFDGRVLTEA AQVRVGSDML
110 120 130 140 150
TRFSIRMFSL LVFRAQSEDS GLYFCGTRKG DYFYAYDVDI QNSEGMVATF
160 170 180 190 200
QDKGQEPFAD EYYGHLHVFT TFWEWTPCDR CGVRGEQWRI GLCYLQSPDL
210 220 230 240 250
SPRYLKAVPD VVSCGSRAVP RKLRTKARDH TPEVLVRSCL VPCEKTKTIR
260 270 280 290 300
EGVLAIINYV SKVGSRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW
310 320 330 340 350
DKDRQHLYRT QYLKGVNRSM RVFIDHGNQL HIRFTQLDDR GIYYCWRQGV
360 370 380 390 400
LVAGFRLGVT SHGHYPASFS DPETRSAVEL TLIGYLLITA VFVTIHFCRC
410
CCYLFHCCPS FSP
Length:413
Mass (Da):47,349
Last modified:July 24, 2007 - v1
Checksum:i580178965D3F9631
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC015936 Genomic DNA. No translation available.
UniGeneiHs.743398.

Genome annotation databases

EnsembliENST00000331733; ENSP00000329499; ENSG00000214447.
UCSCiuc002ihp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC015936 Genomic DNA. No translation available.
UniGenei Hs.743398.

3D structure databases

ProteinModelPortali A6NFU0.
SMRi A6NFU0. Positions 43-127, 275-361.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi A6NFU0.
PRIDEi A6NFU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331733 ; ENSP00000329499 ; ENSG00000214447 .
UCSCi uc002ihp.1. human.

Organism-specific databases

GeneCardsi GC17P042979.
HGNCi HGNC:35153. FAM187A.
HPAi HPA022794.
neXtProti NX_A6NFU0.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72316.
GeneTreei ENSGT00390000004038.
HOGENOMi HOG000155662.
HOVERGENi HBG108742.
InParanoidi A6NFU0.
OMAi SMRVFID.
OrthoDBi EOG751NFT.
PhylomeDBi A6NFU0.
TreeFami TF332178.

Miscellaneous databases

PROi A6NFU0.

Gene expression databases

ExpressionAtlasi A6NFU0. baseline.
Genevestigatori A6NFU0.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiF187A_HUMAN
AccessioniPrimary (citable) accession number: A6NFU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3