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Protein
Submitted name:

Septin-8

Gene

SEPT8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Septin-8Imported
Gene namesi
Name:SEPT8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16511. SEPT8.

PTM / Processingi

Proteomic databases

EPDiA6NFQ9.
MaxQBiA6NFQ9.
PaxDbiA6NFQ9.
PRIDEiA6NFQ9.

Expressioni

Gene expression databases

BgeeiA6NFQ9.
ExpressionAtlasiA6NFQ9. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiA6NFQ9. 3 interactions.
STRINGi9606.ENSP00000367991.

Structurei

3D structure databases

ProteinModelPortaliA6NFQ9.
SMRiA6NFQ9. Positions 21-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 305265Septin-type G (guanine nucleotide-binding)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili343 – 40664Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.UniRule annotationSAAS annotation
Contains septin-type G (guanine nucleotide-binding) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
KOiK16939.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NFQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV
60 70 80 90 100
GETGIGKSTL MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT
110 120 130 140 150
IVDAVGFGDQ INKDERPIVD YIDAQFENYL QEELKIRRSL FDYHDTRIHV
160 170 180 190 200
CLYFITPTGH SLKSLDLVTM KKLDSKVNII PIIAKADTIS KSELHKFKIK
210 220 230 240 250
IMGELVSNGV QIYQFPTDDE AVAEINAVMN AHLPFAVVGS TEEVKVGNKL
260 270 280 290 300
VRARQYPWGV VQVENENHCD FVKLREMLIR VNMEDLREQT HSRHYELYRR
310 320 330 340 350
CKLEEMGFQD SDGDSQPFSL QETYEAKRKE FLSELQRKEE EMRQMFVNKV
360 370 380 390 400
KETELELKEK ERELHEKFEH LKRVHQEEKR KVEEKRRELE EETNAFNRRK
410 420 430 440
AAVEALQSQA LHATSQQPLR KDKDKKKASG WSSIYSVTIP
Length:440
Mass (Da):50,928
Last modified:July 24, 2007 - v1
Checksum:i47EA668689A47D25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004775 Genomic DNA. No translation available.
KF459593 Genomic DNA. No translation available.
RefSeqiNP_001287727.1. NM_001300798.1.
UniGeneiHs.522057.

Genome annotation databases

EnsembliENST00000378701; ENSP00000367973; ENSG00000164402.
GeneIDi23176.
KEGGihsa:23176.
UCSCiuc003kxv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004775 Genomic DNA. No translation available.
KF459593 Genomic DNA. No translation available.
RefSeqiNP_001287727.1. NM_001300798.1.
UniGeneiHs.522057.

3D structure databases

ProteinModelPortaliA6NFQ9.
SMRiA6NFQ9. Positions 21-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NFQ9. 3 interactions.
STRINGi9606.ENSP00000367991.

Proteomic databases

EPDiA6NFQ9.
MaxQBiA6NFQ9.
PaxDbiA6NFQ9.
PRIDEiA6NFQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378701; ENSP00000367973; ENSG00000164402.
GeneIDi23176.
KEGGihsa:23176.
UCSCiuc003kxv.3. human.

Organism-specific databases

CTDi23176.
HGNCiHGNC:16511. SEPT8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
KOiK16939.

Miscellaneous databases

ChiTaRSiSEPT8. human.
GenomeRNAii23176.
NextBioi35462527.

Gene expression databases

BgeeiA6NFQ9.
ExpressionAtlasiA6NFQ9. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiA6NFQ9_HUMAN
AccessioniPrimary (citable) accession number: A6NFQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.