ID   DPRX_HUMAN              Reviewed;         191 AA.
AC   A6NFQ7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 114.
DE   RecName: Full=Divergent paired-related homeobox {ECO:0000305};
GN   Name=DPRX {ECO:0000312|HGNC:HGNC:32166};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=17005330; DOI=10.1016/j.gene.2006.07.034;
RA   Booth H.A., Holland P.W.H.;
RT   "Annotation, nomenclature and evolution of four novel homeobox genes
RT   expressed in the human germ line.";
RL   Gene 387:7-14(2007).
RN   [3]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=27412763; DOI=10.1038/srep28995;
RA   Madissoon E., Jouhilahti E.M., Vesterlund L., Toehoenen V., Krjutskov K.,
RA   Petropoulos S., Einarsdottir E., Linnarsson S., Lanner F., Maansson R.,
RA   Hovatta O., Buerglin T.R., Katayama S., Kere J.;
RT   "Characterization and target genes of nine human PRD-like homeobox domain
RT   genes expressed exclusively in early embryos.";
RL   Sci. Rep. 6:28995-28995(2016).
CC   -!- FUNCTION: Transcription factor that acts as a repressor.
CC       {ECO:0000269|PubMed:27412763}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in single blastomeres from 8-cell stage
CC       embryos. {ECO:0000269|PubMed:27412763}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; AC011487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS33103.1; -.
DR   RefSeq; NP_001012746.1; NM_001012728.1.
DR   RefSeq; XP_011525313.1; XM_011527011.2.
DR   RefSeq; XP_011525314.1; XM_011527012.2.
DR   AlphaFoldDB; A6NFQ7; -.
DR   SMR; A6NFQ7; -.
DR   STRING; 9606.ENSP00000365838; -.
DR   GlyGen; A6NFQ7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; A6NFQ7; -.
DR   PhosphoSitePlus; A6NFQ7; -.
DR   BioMuta; DPRX; -.
DR   EPD; A6NFQ7; -.
DR   PaxDb; 9606-ENSP00000365838; -.
DR   Antibodypedia; 49837; 48 antibodies from 12 providers.
DR   DNASU; 503834; -.
DR   Ensembl; ENST00000376650.2; ENSP00000365838.1; ENSG00000204595.3.
DR   Ensembl; ENST00000710707.1; ENSP00000518423.1; ENSG00000204595.3.
DR   GeneID; 503834; -.
DR   KEGG; hsa:503834; -.
DR   MANE-Select; ENST00000376650.2; ENSP00000365838.1; NM_001012728.2; NP_001012746.1.
DR   UCSC; uc002qcf.1; human.
DR   AGR; HGNC:32166; -.
DR   CTD; 503834; -.
DR   DisGeNET; 503834; -.
DR   GeneCards; DPRX; -.
DR   HGNC; HGNC:32166; DPRX.
DR   HPA; ENSG00000204595; Tissue enhanced (placenta, skeletal muscle).
DR   MIM; 611165; gene.
DR   neXtProt; NX_A6NFQ7; -.
DR   PharmGKB; PA142671957; -.
DR   VEuPathDB; HostDB:ENSG00000204595; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00640000091698; -.
DR   HOGENOM; CLU_135951_0_0_1; -.
DR   InParanoid; A6NFQ7; -.
DR   OMA; RTMFTKK; -.
DR   OrthoDB; 4732592at2759; -.
DR   PhylomeDB; A6NFQ7; -.
DR   SignaLink; A6NFQ7; -.
DR   BioGRID-ORCS; 503834; 9 hits in 1159 CRISPR screens.
DR   ChiTaRS; DPRX; human.
DR   GenomeRNAi; 503834; -.
DR   Pharos; A6NFQ7; Tdark.
DR   PRO; PR:A6NFQ7; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NFQ7; Protein.
DR   Bgee; ENSG00000204595; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 36 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   PANTHER; PTHR45793:SF15; DIVERGENT PAIRED-RELATED HOMEOBOX; 1.
DR   PANTHER; PTHR45793; HOMEOBOX PROTEIN; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..191
FT                   /note="Divergent paired-related homeobox"
FT                   /id="PRO_0000311326"
FT   DNA_BIND        16..75
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   191 AA;  21648 MW;  D804219AD5A69066 CRC64;
     MPGSEDLRKG KDQMHSHRKR TMFTKKQLED LNILFNENPY PNPSLQKEMA SKIDIHPTVL
     QVWFKNHRAK LKKAKCKHIH QKQETPQPPI PEGGVSTSVG LRNADTLPRL PNAAHPIGLV
     YTGHRVPSFQ LILYPNLKVP ANDFIGHRIV HFGCCRDPNI YCLYPILESQ VCAPSFHSGS
     PACSSNQSRE R
//