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A6NFQ7

- DPRX_HUMAN

UniProt

A6NFQ7 - DPRX_HUMAN

Protein

Divergent paired-related homeobox

Gene

DPRX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Putative transcription factor.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi16 – 7560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Divergent paired-related homeobox
    Gene namesi
    Name:DPRX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:32166. DPRX.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671957.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191Divergent paired-related homeoboxPRO_0000311326Add
    BLAST

    Proteomic databases

    PaxDbiA6NFQ7.
    PRIDEiA6NFQ7.

    Expressioni

    Gene expression databases

    CleanExiHS_DPRX.
    GenevestigatoriA6NFQ7.

    Organism-specific databases

    HPAiHPA043682.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000365838.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NFQ7.
    SMRiA6NFQ7. Positions 18-73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG279221.
    HOGENOMiHOG000112264.
    InParanoidiA6NFQ7.
    OMAiHRKRTMF.
    OrthoDBiEOG7S7SFW.
    PhylomeDBiA6NFQ7.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NFQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGSEDLRKG KDQMHSHRKR TMFTKKQLED LNILFNENPY PNPSLQKEMA    50
    SKIDIHPTVL QVWFKNHRAK LKKAKCKHIH QKQETPQPPI PEGGVSTSVG 100
    LRNADTLPRL PNAAHPIGLV YTGHRVPSFQ LILYPNLKVP ANDFIGHRIV 150
    HFGCCRDPNI YCLYPILESQ VCAPSFHSGS PACSSNQSRE R 191
    Length:191
    Mass (Da):21,648
    Last modified:July 24, 2007 - v1
    Checksum:iD804219AD5A69066
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC011487 Genomic DNA. No translation available.
    CCDSiCCDS33103.1.
    RefSeqiNP_001012746.1. NM_001012728.1.
    UniGeneiHs.579941.

    Genome annotation databases

    EnsembliENST00000376650; ENSP00000365838; ENSG00000204595.
    GeneIDi503834.
    KEGGihsa:503834.
    UCSCiuc002qcf.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC011487 Genomic DNA. No translation available.
    CCDSi CCDS33103.1.
    RefSeqi NP_001012746.1. NM_001012728.1.
    UniGenei Hs.579941.

    3D structure databases

    ProteinModelPortali A6NFQ7.
    SMRi A6NFQ7. Positions 18-73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000365838.

    Proteomic databases

    PaxDbi A6NFQ7.
    PRIDEi A6NFQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376650 ; ENSP00000365838 ; ENSG00000204595 .
    GeneIDi 503834.
    KEGGi hsa:503834.
    UCSCi uc002qcf.1. human.

    Organism-specific databases

    CTDi 503834.
    GeneCardsi GC19P054136.
    HGNCi HGNC:32166. DPRX.
    HPAi HPA043682.
    MIMi 611165. gene.
    neXtProti NX_A6NFQ7.
    PharmGKBi PA142671957.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279221.
    HOGENOMi HOG000112264.
    InParanoidi A6NFQ7.
    OMAi HRKRTMF.
    OrthoDBi EOG7S7SFW.
    PhylomeDBi A6NFQ7.

    Miscellaneous databases

    NextBioi 112038.
    PROi A6NFQ7.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_DPRX.
    Genevestigatori A6NFQ7.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line."
      Booth H.A., Holland P.W.H.
      Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiDPRX_HUMAN
    AccessioniPrimary (citable) accession number: A6NFQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3