Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6NFQ7 (DPRX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Divergent paired-related homeobox
Gene names
Name:DPRX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative transcription factor By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Divergent paired-related homeobox
PRO_0000311326

Regions

DNA binding16 – 7560Homeobox

Sequences

Sequence LengthMass (Da)Tools
A6NFQ7 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: D804219AD5A69066

FASTA19121,648
        10         20         30         40         50         60 
MPGSEDLRKG KDQMHSHRKR TMFTKKQLED LNILFNENPY PNPSLQKEMA SKIDIHPTVL 

        70         80         90        100        110        120 
QVWFKNHRAK LKKAKCKHIH QKQETPQPPI PEGGVSTSVG LRNADTLPRL PNAAHPIGLV 

       130        140        150        160        170        180 
YTGHRVPSFQ LILYPNLKVP ANDFIGHRIV HFGCCRDPNI YCLYPILESQ VCAPSFHSGS 

       190 
PACSSNQSRE R 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line."
Booth H.A., Holland P.W.H.
Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC011487 Genomic DNA. No translation available.
CCDSCCDS33103.1.
RefSeqNP_001012746.1. NM_001012728.1.
UniGeneHs.579941.

3D structure databases

ProteinModelPortalA6NFQ7.
SMRA6NFQ7. Positions 18-73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000365838.

Proteomic databases

PaxDbA6NFQ7.
PRIDEA6NFQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376650; ENSP00000365838; ENSG00000204595.
GeneID503834.
KEGGhsa:503834.
UCSCuc002qcf.1. human.

Organism-specific databases

CTD503834.
GeneCardsGC19P054136.
HGNCHGNC:32166. DPRX.
HPAHPA043682.
MIM611165. gene.
neXtProtNX_A6NFQ7.
PharmGKBPA142671957.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279221.
HOGENOMHOG000112264.
InParanoidA6NFQ7.
OMAHRKRTMF.
OrthoDBEOG7S7SFW.
PhylomeDBA6NFQ7.

Gene expression databases

CleanExHS_DPRX.
GenevestigatorA6NFQ7.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio112038.
PROA6NFQ7.
SOURCESearch...

Entry information

Entry nameDPRX_HUMAN
AccessionPrimary (citable) accession number: A6NFQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM