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Protein

Divergent paired-related homeobox

Gene

DPRX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi16 – 7560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Divergent paired-related homeobox
Gene namesi
Name:DPRX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32166. DPRX.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671957.

Polymorphism and mutation databases

BioMutaiDPRX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191Divergent paired-related homeoboxPRO_0000311326Add
BLAST

Proteomic databases

PaxDbiA6NFQ7.
PRIDEiA6NFQ7.

Expressioni

Gene expression databases

CleanExiHS_DPRX.

Organism-specific databases

HPAiHPA043682.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365838.

Structurei

3D structure databases

ProteinModelPortaliA6NFQ7.
SMRiA6NFQ7. Positions 18-73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG279221.
GeneTreeiENSGT00640000091698.
HOGENOMiHOG000112264.
InParanoidiA6NFQ7.
OMAiHRKRTMF.
OrthoDBiEOG7S7SFW.
PhylomeDBiA6NFQ7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NFQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSEDLRKG KDQMHSHRKR TMFTKKQLED LNILFNENPY PNPSLQKEMA
60 70 80 90 100
SKIDIHPTVL QVWFKNHRAK LKKAKCKHIH QKQETPQPPI PEGGVSTSVG
110 120 130 140 150
LRNADTLPRL PNAAHPIGLV YTGHRVPSFQ LILYPNLKVP ANDFIGHRIV
160 170 180 190
HFGCCRDPNI YCLYPILESQ VCAPSFHSGS PACSSNQSRE R
Length:191
Mass (Da):21,648
Last modified:July 24, 2007 - v1
Checksum:iD804219AD5A69066
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011487 Genomic DNA. No translation available.
CCDSiCCDS33103.1.
RefSeqiNP_001012746.1. NM_001012728.1.
UniGeneiHs.579941.

Genome annotation databases

EnsembliENST00000376650; ENSP00000365838; ENSG00000204595.
GeneIDi503834.
KEGGihsa:503834.
UCSCiuc002qcf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011487 Genomic DNA. No translation available.
CCDSiCCDS33103.1.
RefSeqiNP_001012746.1. NM_001012728.1.
UniGeneiHs.579941.

3D structure databases

ProteinModelPortaliA6NFQ7.
SMRiA6NFQ7. Positions 18-73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365838.

Polymorphism and mutation databases

BioMutaiDPRX.

Proteomic databases

PaxDbiA6NFQ7.
PRIDEiA6NFQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376650; ENSP00000365838; ENSG00000204595.
GeneIDi503834.
KEGGihsa:503834.
UCSCiuc002qcf.1. human.

Organism-specific databases

CTDi503834.
GeneCardsiGC19P054136.
HGNCiHGNC:32166. DPRX.
HPAiHPA043682.
MIMi611165. gene.
neXtProtiNX_A6NFQ7.
PharmGKBiPA142671957.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279221.
GeneTreeiENSGT00640000091698.
HOGENOMiHOG000112264.
InParanoidiA6NFQ7.
OMAiHRKRTMF.
OrthoDBiEOG7S7SFW.
PhylomeDBiA6NFQ7.

Miscellaneous databases

GenomeRNAii503834.
NextBioi112038.
PROiA6NFQ7.
SOURCEiSearch...

Gene expression databases

CleanExiHS_DPRX.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line."
    Booth H.A., Holland P.W.H.
    Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiDPRX_HUMAN
AccessioniPrimary (citable) accession number: A6NFQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.