A6NFQ7 (DPRX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Divergent paired-related homeobox

Gene names

Name:

DPRX

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative transcription factor By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Divergent paired-related homeobox		PRO_0000311326
Regions
	DNA binding	16 – 75	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	A6NFQ7 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: D804219AD5A69066	FASTA	191	21,648
	10 20 30 40 50 60 MPGSEDLRKG KDQMHSHRKR TMFTKKQLED LNILFNENPY PNPSLQKEMA SKIDIHPTVL 70 80 90 100 110 120 QVWFKNHRAK LKKAKCKHIH QKQETPQPPI PEGGVSTSVG LRNADTLPRL PNAAHPIGLV 130 140 150 160 170 180 YTGHRVPSFQ LILYPNLKVP ANDFIGHRIV HFGCCRDPNI YCLYPILESQ VCAPSFHSGS 190 PACSSNQSRE R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line." Booth H.A., Holland P.W.H. Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC011487 Genomic DNA. No translation available.
IPI	IPI00556337.
RefSeq	NP_001012746.1. NM_001012728.1.
UniGene	Hs.579941.
3D structure databases
ProteinModelPortal	A6NFQ7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000365838.
Proteomic databases
PaxDb	A6NFQ7.
PRIDE	A6NFQ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376650; ENSP00000365838; ENSG00000204595.
GeneID	503834.
KEGG	hsa:503834.
UCSC	uc002qcf.1. human.
Organism-specific databases
CTD	503834.
GeneCards	GC19P054136.
HGNC	HGNC:32166. DPRX.
HPA	HPA043682.
MIM	611165. gene.
neXtProt	NX_A6NFQ7.
PharmGKB	PA142671957.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279221.
HOGENOM	HOG000112264.
InParanoid	A6NFQ7.
OMA	IVHFGCC.
OrthoDB	EOG47WNPP.
Gene expression databases
CleanEx	HS_DPRX.
Genevestigator	A6NFQ7.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	112038.
SOURCE	Search...

Entry information

Entry name

DPRX_HUMAN

Accession

Primary (citable) accession number: A6NFQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.