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A6NFQ7

- DPRX_HUMAN

UniProt

A6NFQ7 - DPRX_HUMAN

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Protein

Divergent paired-related homeobox

Gene
DPRX
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative transcription factor By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi16 – 7560HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Divergent paired-related homeobox
Gene namesi
Name:DPRX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:32166. DPRX.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191Divergent paired-related homeoboxPRO_0000311326Add
BLAST

Proteomic databases

PaxDbiA6NFQ7.
PRIDEiA6NFQ7.

Expressioni

Gene expression databases

CleanExiHS_DPRX.
GenevestigatoriA6NFQ7.

Organism-specific databases

HPAiHPA043682.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365838.

Structurei

3D structure databases

ProteinModelPortaliA6NFQ7.
SMRiA6NFQ7. Positions 18-73.

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG279221.
HOGENOMiHOG000112264.
InParanoidiA6NFQ7.
OMAiHRKRTMF.
OrthoDBiEOG7S7SFW.
PhylomeDBiA6NFQ7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NFQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MPGSEDLRKG KDQMHSHRKR TMFTKKQLED LNILFNENPY PNPSLQKEMA    50
SKIDIHPTVL QVWFKNHRAK LKKAKCKHIH QKQETPQPPI PEGGVSTSVG 100
LRNADTLPRL PNAAHPIGLV YTGHRVPSFQ LILYPNLKVP ANDFIGHRIV 150
HFGCCRDPNI YCLYPILESQ VCAPSFHSGS PACSSNQSRE R 191
Length:191
Mass (Da):21,648
Last modified:July 24, 2007 - v1
Checksum:iD804219AD5A69066
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011487 Genomic DNA. No translation available.
CCDSiCCDS33103.1.
RefSeqiNP_001012746.1. NM_001012728.1.
UniGeneiHs.579941.

Genome annotation databases

EnsembliENST00000376650; ENSP00000365838; ENSG00000204595.
GeneIDi503834.
KEGGihsa:503834.
UCSCiuc002qcf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011487 Genomic DNA. No translation available.
CCDSi CCDS33103.1.
RefSeqi NP_001012746.1. NM_001012728.1.
UniGenei Hs.579941.

3D structure databases

ProteinModelPortali A6NFQ7.
SMRi A6NFQ7. Positions 18-73.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000365838.

Proteomic databases

PaxDbi A6NFQ7.
PRIDEi A6NFQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376650 ; ENSP00000365838 ; ENSG00000204595 .
GeneIDi 503834.
KEGGi hsa:503834.
UCSCi uc002qcf.1. human.

Organism-specific databases

CTDi 503834.
GeneCardsi GC19P054136.
HGNCi HGNC:32166. DPRX.
HPAi HPA043682.
MIMi 611165. gene.
neXtProti NX_A6NFQ7.
PharmGKBi PA142671957.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279221.
HOGENOMi HOG000112264.
InParanoidi A6NFQ7.
OMAi HRKRTMF.
OrthoDBi EOG7S7SFW.
PhylomeDBi A6NFQ7.

Miscellaneous databases

NextBioi 112038.
PROi A6NFQ7.
SOURCEi Search...

Gene expression databases

CleanExi HS_DPRX.
Genevestigatori A6NFQ7.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line."
    Booth H.A., Holland P.W.H.
    Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiDPRX_HUMAN
AccessioniPrimary (citable) accession number: A6NFQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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