A6NFN4 (A6NFN4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Uncharacterized protein Ensembl ENSP00000368776

Submitted name:
cDNA FLJ55878, highly similar to NEDD8-activating enzyme E1 regulatory subunit EMBL BAH12735.1

Gene names

Name:

NAE1 Ensembl ENSP00000368776

Organism

Homo sapiens (Human) Ensembl ENSP00000368776

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6NFN4 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: F3732BF1F365C633	FASTA	528	59,420
	10 20 30 40 50 60 MDAQQTKTNE ARLWGDHGQE ALESAHVCLI NATATGTEIL KNLVLPGIGS FTIIDGNQVS 70 80 90 100 110 120 GEDAGNNFFL QRSSIGKNRA EAAMEFLQEL NSDVSGSFVE ESPENLLDND PSFFCRFTVV 130 140 150 160 170 180 VATQLPESTS LRLADVLWNS QIPLLICRTY GLVGYMRIII KEHPVIESHP DNALEDLRLD 190 200 210 220 230 240 KPFPELREHF QSYDLDHMEK KDHSHTPWIV IIAKYLAQWY SETNGRIPKT YKEKEDFRDL 250 260 270 280 290 300 IRQGILKNEN GAPEDEENFE EAIKNVNTAL NTTQIPSSIE DIFNDDRCIN ITKQTPSFWI 310 320 330 340 350 360 LARALKEFVA KEGQGNLPVR GTIPDMIADS GKYIKLQNVY REKAKKDAAA VGNHVAKLLQ 370 380 390 400 410 420 SIGQAPESIS EKELKLLCSN SAFLRVVRCR SLAEEYGLDT INKDEIISSM DNPDNEIVLY 430 440 450 460 470 480 LMLRAVDRFH KQQGRYPGVS NYQVEEDIGK LKSCLTGFLQ EYGLSVMVKD DYVHEFCRYG 490 500 510 520 AAEPHTIAAF LGGAAAQEVI KIITKQFVIF NNTYIYSGMS QTSATFQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC044802 Genomic DNA. No translation available. AK298159 mRNA. Translation: BAH12735.1.
IPI	IPI00604676.
RefSeq	NP_001018169.1. NM_001018159.1.
UniGene	Hs.460978.
3D structure databases
ProteinModelPortal	A6NFN4.
SMR	A6NFN4. Positions 4-528.
ModBase	Search...
Protein-protein interaction databases
STRING	A6NFN4.
Proteomic databases
PRIDE	A6NFN4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379463; ENSP00000368776; ENSG00000159593.
GeneID	8883.
KEGG	hsa:8883.
Organism-specific databases
CTD	8883.
HGNC	HGNC:621. NAE1.
PharmGKB	PA162396730.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG079761.
Gene expression databases
Bgee	A6NFN4.
Family and domain databases
InterPro	IPR009036. Molybdenum_cofac_synth_MoeB. IPR016040. NAD(P)-bd_dom. IPR000594. ThiF_NAD_FAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 3 hits.
KO	K04532.
Pfam	PF00899. ThiF. 1 hit. [Graphical view]
SUPFAM	SSF69572. MoeB. 1 hit.
ProtoNet	Search...
Other
NextBio	33357.

Entry information

Entry name

A6NFN4_HUMAN

Accession

Primary (citable) accession number: A6NFN4

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.