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Protein

RNA binding protein fox-1 homolog 3

Gene

RBFOX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein that regulates alternative splicing events.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 3
Alternative name(s):
Fox-1 homolog C
Gene namesi
Name:RBFOX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:27097. RBFOX3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312RNA binding protein fox-1 homolog 3PRO_0000349207Add
BLAST

Proteomic databases

PaxDbiA6NFN3.
PRIDEiA6NFN3.

PTM databases

iPTMnetiA6NFN3.
PhosphoSiteiA6NFN3.

Expressioni

Gene expression databases

BgeeiENSG00000167281.
ExpressionAtlasiA6NFN3. baseline and differential.

Organism-specific databases

HPAiHPA030790.

Interactioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei100 – 1001Interaction with RNABy similarity
Sitei108 – 1081Interaction with RNABy similarity
Sitei109 – 1091Interaction with RNABy similarity
Sitei133 – 1331Interaction with RNABy similarity
Sitei138 – 1381Interaction with RNABy similarity
Sitei142 – 1421Interaction with RNABy similarity
Sitei166 – 1661Interaction with RNABy similarity
Sitei176 – 1761Interaction with RNABy similarity

Protein-protein interaction databases

BioGridi127004. 6 interactions.
STRINGi9606.ENSP00000393262.

Structurei

3D structure databases

ProteinModelPortaliA6NFN3.
SMRiA6NFN3. Positions 98-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 17576RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 4037Pro-richAdd
BLAST
Compositional biasi277 – 2826Poly-Ala

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOGENOMiHOG000230971.
HOVERGENiHBG000044.
InParanoidiA6NFN3.
KOiK14946.
PhylomeDBiA6NFN3.
TreeFamiTF315942.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NFN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQPYPPAQY PPPPQNGIPA EYAPPPPHPT QDYSGQTPVP TEHGMTLYTP
60 70 80 90 100
AQTHPEQPGS EASTQPIAGT QTVPQTDEAA QTDSQPLHPS DPTEKQQPKR
110 120 130 140 150
LHVSNIPFRF RDPDLRQMFG QFGKILDVEI IFNERGSKGF GFVTFETSSD
160 170 180 190 200
ADRAREKLNG TIVEGRKIEV NNATARVMTN KKTGNPYTNG WKLNPVVGAV
210 220 230 240 250
YGPEFYAVTG FPYPTTGTAV AYRGAHLRGR GRAVYNTFRA APPPPPIPTY
260 270 280 290 300
GAVVYQDGFY GAEIYGGYAA YRYAQPAAAA AAYSDSYGRV YAAADPYHHT
310
IGPAATYSIG TM
Length:312
Mass (Da):33,873
Last modified:February 8, 2011 - v4
Checksum:i62D564F8A7862862
GO
Isoform 2 (identifier: A6NFN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: M → MVRSPGPPSPGCQS

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):35,123
Checksum:i53ECD61C4CC86F5B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei312 – 3121M → MVRSPGPPSPGCQS in isoform 2. 1 PublicationVSP_056241

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293617 mRNA. Translation: BAG57077.1.
AK293905 mRNA. Translation: BAG57290.1.
AC020689 Genomic DNA. No translation available.
AC021534 Genomic DNA. No translation available.
AC027824 Genomic DNA. No translation available.
AC055858 Genomic DNA. No translation available.
AC073624 Genomic DNA. No translation available.
AC142247 Genomic DNA. No translation available.
CCDSiCCDS45805.1. [A6NFN3-1]
RefSeqiNP_001076044.1. NM_001082575.2. [A6NFN3-1]
UniGeneiHs.135229.
Hs.574437.

Genome annotation databases

EnsembliENST00000580155; ENSP00000463653; ENSG00000167281. [A6NFN3-1]
ENST00000584778; ENSP00000462007; ENSG00000167281. [A6NFN3-2]
GeneIDi146713.
KEGGihsa:146713.
UCSCiuc010dhs.5. human. [A6NFN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293617 mRNA. Translation: BAG57077.1.
AK293905 mRNA. Translation: BAG57290.1.
AC020689 Genomic DNA. No translation available.
AC021534 Genomic DNA. No translation available.
AC027824 Genomic DNA. No translation available.
AC055858 Genomic DNA. No translation available.
AC073624 Genomic DNA. No translation available.
AC142247 Genomic DNA. No translation available.
CCDSiCCDS45805.1. [A6NFN3-1]
RefSeqiNP_001076044.1. NM_001082575.2. [A6NFN3-1]
UniGeneiHs.135229.
Hs.574437.

3D structure databases

ProteinModelPortaliA6NFN3.
SMRiA6NFN3. Positions 98-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127004. 6 interactions.
STRINGi9606.ENSP00000393262.

PTM databases

iPTMnetiA6NFN3.
PhosphoSiteiA6NFN3.

Proteomic databases

PaxDbiA6NFN3.
PRIDEiA6NFN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000580155; ENSP00000463653; ENSG00000167281. [A6NFN3-1]
ENST00000584778; ENSP00000462007; ENSG00000167281. [A6NFN3-2]
GeneIDi146713.
KEGGihsa:146713.
UCSCiuc010dhs.5. human. [A6NFN3-1]

Organism-specific databases

CTDi146713.
GeneCardsiRBFOX3.
HGNCiHGNC:27097. RBFOX3.
HPAiHPA030790.
neXtProtiNX_A6NFN3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOGENOMiHOG000230971.
HOVERGENiHBG000044.
InParanoidiA6NFN3.
KOiK14946.
PhylomeDBiA6NFN3.
TreeFamiTF315942.

Miscellaneous databases

ChiTaRSiRBFOX3. human.
GenomeRNAii146713.
PROiA6NFN3.

Gene expression databases

BgeeiENSG00000167281.
ExpressionAtlasiA6NFN3. baseline and differential.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFOX3_HUMAN
AccessioniPrimary (citable) accession number: A6NFN3
Secondary accession number(s): B4DEG6, B4DF29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 8, 2011
Last modified: September 7, 2016
This is version 74 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.