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A6NFN2

- A6NFN2_HUMAN

UniProt

A6NFN2 - A6NFN2_HUMAN

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Protein
Submitted name: Abl interactor 1
Gene
ABI1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein tyrosine kinase activator activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Abl interactor 1Imported
    Gene namesi
    Name:ABI1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:11320. ABI1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    Complete GO annotation...

    PTM / Processingi

    Proteomic databases

    PRIDEiA6NFN2.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NFN2.
    BgeeiA6NFN2.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NFN2.
    SMRiA6NFN2. Positions 1-154, 437-504.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SH3 domain.UniRule annotation

    Keywords - Domaini

    SH3 domainUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000293213.
    HOVERGENiHBG050446.
    OMAiMPMFDDS.
    PhylomeDBiA6NFN2.

    Family and domain databases

    InterProiIPR028457. ABI.
    IPR028456. ABI1.
    IPR012849. Abl-interactor_HHR_dom.
    IPR001452. SH3_domain.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR10460. PTHR10460. 1 hit.
    PTHR10460:SF2. PTHR10460:SF2. 1 hit.
    PfamiPF07815. Abi_HHR. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NFN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET    50
    KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH 100
    KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG 150
    HGVKKWHKII HGNNQPARTG TLSRTNPPTQ KPPSPPMSGR GTLGRNTPYK 200
    TLEPVKPPTV PNDYMTSPAR LGSQHSPGRT ASLNQRPRTH SGSSGGSGSR 250
    ENSGSSSIGI PIAVPTPSPP TIGPENISVP PPSGAPPAPP LAPLLPVSTV 300
    IAAPGSAPGS QYGTMTRQIS RHNSTTSSTS SGGYRRTPSV TAQFSAQPHV 350
    NGGPLYSQNS ISIAPPPPPM PQLTPQIPLT GFVARVQENI ADSPTPPPPP 400
    PPDDIPMFDD SPPPPPPPPV DYEDEEAAVV QYNDPYADGD PAWAPKNYIE 450
    KVVAIYDYTK DKDDELSFME GAIIYVIKKN DDGWYEGVCN RVTGLFPGNY 500
    VESIMHYTD 509
    Length:509
    Mass (Da):55,260
    Last modified:January 15, 2008 - v2
    Checksum:iC835E45FBF66BC9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL139404 Genomic DNA. No translation available.
    AL390961 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000355394; ENSP00000347555; ENSG00000136754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL139404 Genomic DNA. No translation available.
    AL390961 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A6NFN2.
    SMRi A6NFN2. Positions 1-154, 437-504.
    ModBasei Search...

    Proteomic databases

    PRIDEi A6NFN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355394 ; ENSP00000347555 ; ENSG00000136754 .

    Organism-specific databases

    HGNCi HGNC:11320. ABI1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000293213.
    HOVERGENi HBG050446.
    OMAi MPMFDDS.
    PhylomeDBi A6NFN2.

    Miscellaneous databases

    ChiTaRSi ABI1. human.
    NextBioi 35462525.

    Gene expression databases

    ArrayExpressi A6NFN2.
    Bgeei A6NFN2.

    Family and domain databases

    InterProi IPR028457. ABI.
    IPR028456. ABI1.
    IPR012849. Abl-interactor_HHR_dom.
    IPR001452. SH3_domain.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR10460. PTHR10460. 1 hit.
    PTHR10460:SF2. PTHR10460:SF2. 1 hit.
    Pfami PF07815. Abi_HHR. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
    10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiA6NFN2_HUMAN
    AccessioniPrimary (citable) accession number: A6NFN2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 24, 2007
    Last sequence update: January 15, 2008
    Last modified: June 11, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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