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Protein

Zinc finger protein 316

Gene

ZNF316

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri345 – 367C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 512C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST28
Zinc fingeri691 – 713C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri747 – 769C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 797C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri803 – 825C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri831 – 853C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri859 – 881C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri887 – 909C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri915 – 937C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33167-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 316
Gene namesi
Name:ZNF316
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13843. ZNF316.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003489422 – 1004Zinc finger protein 316Add BLAST1003

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphothreonineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA6NFI3.
MaxQBiA6NFI3.
PRIDEiA6NFI3.

PTM databases

iPTMnetiA6NFI3.
PhosphoSitePlusiA6NFI3.

Expressioni

Gene expression databases

ExpressionAtlasiA6NFI3. baseline and differential.
GenevisibleiA6NFI3. HS.

Interactioni

Protein-protein interaction databases

BioGridi133162. 11 interactors.
IntActiA6NFI3. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA6NFI3.
SMRiA6NFI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 229KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri345 – 367C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 512C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST28
Zinc fingeri691 – 713C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri747 – 769C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 797C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri803 – 825C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri831 – 853C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri859 – 881C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri887 – 909C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri915 – 937C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00810000125587.
HOVERGENiHBG018163.
InParanoidiA6NFI3.
KOiK09228.
OMAiTSFGSEH.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NFI3.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NFI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALHTTPDS PAAQLERAED GSECDPDQEE EEEEEEKGEE VQEVEEEEEE
60 70 80 90 100
IVVEEEEEGV AEVVQDAQVE AVAEVEVEAD VEEEDVKEVL AEEECPALGT
110 120 130 140 150
QERLSRGGDA KSPVLQEKGL QASRAPATPR DEDLEEEEEE EEDEDEDDLL
160 170 180 190 200
TAGCQELVTF EDVAVYFSLE EWERLEADQR GLYQEVMQEN YGILVSLGYP
210 220 230 240 250
IPKPDLIFRL EQGEEPWVPD SPRPEEGDIV TGVYTGAWFW TDDIEDHEEE
260 270 280 290 300
DDEDFLAEVA EEENEPPGLW SAAYGVGDVP GTWGPDDSDS AQTPEGWGPD
310 320 330 340 350
PGGLGVLADG SEAKPFLPGR EPGANLLSPW AFPAAVAPPA GRPETTCDVC
360 370 380 390 400
GKVFPHRSRL AKHQRYHAAV KPFGCEECGK GFVYRSHLAI HQRTHTGEKP
410 420 430 440 450
FPCPDCGKRF VYKSHLVTHR RIHTGERPYR CAFCGAGFGR RSYLVTHQRT
460 470 480 490 500
HTGERPYPCS HCGRSFSQSS ALARHQAVHT ADRPHCCPDC GQAFRLRADF
510 520 530 540 550
QRHRRGGGCA EAGGDGPRRE PGETAAAAGP EDTDPGPEGS EVGEADGEAE
560 570 580 590 600
AAAEEREEAA VAAPTPSGKV DPAPERRFLE LGNGLGEGEG PSSHPLGFHF
610 620 630 640 650
PVHPKSWLHP DSFPILGLPD FRERLPVDGR PLPAPLGGPL SLVEGTGLAC
660 670 680 690 700
DPFGGGGAAG GGGGLRAFGP AIGGLLAEPA PAALAEEESP WICSDCGKTF
710 720 730 740 750
GRRAALAKHQ RYHAGERPHR CADCGKSFVY GSHLARHRRT HTGERPFPCP
760 770 780 790 800
ECGARFARGS HLAAHVRGHT GEKPFVCGVC GAGFSRRAHL TAHGRAHTGE
810 820 830 840 850
RPYACGECGR RFGQSAALTR HQWAHAEEKP HRCPDCGKGF GHSSDFKRHR
860 870 880 890 900
RTHTGEKPFR CADCGRGFAQ RSNLAKHRRG HTGERPFPCP ECGKRFSQRS
910 920 930 940 950
VLVTHQRTHT GERPYACANC GRRFSQSSHL LTHMKTHRGA TAAPGSGSAP
960 970 980 990 1000
APAPKPEAAA KGPSSAGPGE RGSALLEFAG GTSFGSEHQA AFAGPSGAYR

EGVL
Length:1,004
Mass (Da):108,437
Last modified:July 24, 2007 - v1
Checksum:i1BF2A63E5461AA98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073343 Genomic DNA. No translation available.
CCDSiCCDS75563.1.
RefSeqiNP_001265488.1. NM_001278559.1.
XP_006715693.1. XM_006715630.3.
UniGeneiHs.112668.
Hs.720748.
Hs.720750.

Genome annotation databases

EnsembliENST00000382252; ENSP00000477706; ENSG00000205903.
GeneIDi100131017.
KEGGihsa:100131017.
UCSCiuc021zzj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073343 Genomic DNA. No translation available.
CCDSiCCDS75563.1.
RefSeqiNP_001265488.1. NM_001278559.1.
XP_006715693.1. XM_006715630.3.
UniGeneiHs.112668.
Hs.720748.
Hs.720750.

3D structure databases

ProteinModelPortaliA6NFI3.
SMRiA6NFI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133162. 11 interactors.
IntActiA6NFI3. 1 interactor.

PTM databases

iPTMnetiA6NFI3.
PhosphoSitePlusiA6NFI3.

Proteomic databases

EPDiA6NFI3.
MaxQBiA6NFI3.
PRIDEiA6NFI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382252; ENSP00000477706; ENSG00000205903.
GeneIDi100131017.
KEGGihsa:100131017.
UCSCiuc021zzj.3. human.

Organism-specific databases

CTDi100131017.
GeneCardsiZNF316.
HGNCiHGNC:13843. ZNF316.
neXtProtiNX_A6NFI3.
OpenTargetsiENSG00000205903.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00810000125587.
HOVERGENiHBG018163.
InParanoidiA6NFI3.
KOiK09228.
OMAiTSFGSEH.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NFI3.

Enzyme and pathway databases

BioCyciZFISH:G66-33167-MONOMER.

Miscellaneous databases

GenomeRNAii100131017.
PROiA6NFI3.

Gene expression databases

ExpressionAtlasiA6NFI3. baseline and differential.
GenevisibleiA6NFI3. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN316_HUMAN
AccessioniPrimary (citable) accession number: A6NFI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.