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Protein

Fatty acid-binding protein 12

Gene

FABP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in lipid transport.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Fatty acidBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein 12
Gene namesi
Name:FABP12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:34524. FABP12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719513.

Polymorphism and mutation databases

BioMutaiFABP12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Fatty acid-binding protein 12PRO_0000342881Add
BLAST

Proteomic databases

PaxDbiA6NFH5.
PRIDEiA6NFH5.

PTM databases

iPTMnetiA6NFH5.
PhosphoSiteiA6NFH5.

Expressioni

Tissue specificityi

Expressed in a number of retinoblastoma cell lines.1 Publication

Developmental stagei

Not detected in fetal tissues.1 Publication

Gene expression databases

BgeeiA6NFH5.
ExpressionAtlasiA6NFH5. baseline and differential.

Organism-specific databases

HPAiHPA044041.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353650.

Structurei

3D structure databases

ProteinModelPortaliA6NFH5.
SMRiA6NFH5. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiA6NFH5.
OMAiWDGKENT.
PhylomeDBiA6NFH5.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031261. FABP12.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF76. PTHR11955:SF76. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NFH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDQLQGTWK SISCENSEDY MKELGIGRAS RKLGRLAKPT VTISTDGDVI
60 70 80 90 100
TIKTKSIFKN NEISFKLGEE FEEITPGGHK TKSKVTLDKE SLIQVQDWDG
110 120 130 140
KETTITRKLV DGKMVVESTV NSVICTRTYE KVSSNSVSNS
Length:140
Mass (Da):15,565
Last modified:July 1, 2008 - v2
Checksum:i0231973A7A7F260B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU733650 mRNA. Translation: ACI03640.1.
AC023644 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87093.1.
BC146973 mRNA. Translation: AAI46974.1.
BC146981 mRNA. Translation: AAI46982.1.
AX785170 mRNA. No translation available.
AX785174 mRNA. No translation available.
CCDSiCCDS47882.1.
RefSeqiNP_001098751.1. NM_001105281.1.
XP_005251342.1. XM_005251285.3.
XP_006716528.1. XM_006716465.2.
XP_011515877.1. XM_011517575.1.
XP_011515878.1. XM_011517576.1.
XP_011515879.1. XM_011517577.1.
UniGeneiHs.586370.

Genome annotation databases

EnsembliENST00000360464; ENSP00000353650; ENSG00000197416.
GeneIDi646486.
KEGGihsa:646486.
UCSCiuc011lfp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU733650 mRNA. Translation: ACI03640.1.
AC023644 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87093.1.
BC146973 mRNA. Translation: AAI46974.1.
BC146981 mRNA. Translation: AAI46982.1.
AX785170 mRNA. No translation available.
AX785174 mRNA. No translation available.
CCDSiCCDS47882.1.
RefSeqiNP_001098751.1. NM_001105281.1.
XP_005251342.1. XM_005251285.3.
XP_006716528.1. XM_006716465.2.
XP_011515877.1. XM_011517575.1.
XP_011515878.1. XM_011517576.1.
XP_011515879.1. XM_011517577.1.
UniGeneiHs.586370.

3D structure databases

ProteinModelPortaliA6NFH5.
SMRiA6NFH5. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353650.

PTM databases

iPTMnetiA6NFH5.
PhosphoSiteiA6NFH5.

Polymorphism and mutation databases

BioMutaiFABP12.

Proteomic databases

PaxDbiA6NFH5.
PRIDEiA6NFH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360464; ENSP00000353650; ENSG00000197416.
GeneIDi646486.
KEGGihsa:646486.
UCSCiuc011lfp.3. human.

Organism-specific databases

CTDi646486.
GeneCardsiFABP12.
HGNCiHGNC:34524. FABP12.
HPAiHPA044041.
neXtProtiNX_A6NFH5.
PharmGKBiPA164719513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiA6NFH5.
OMAiWDGKENT.
PhylomeDBiA6NFH5.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-HSA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

GenomeRNAii646486.
PROiA6NFH5.

Gene expression databases

BgeeiA6NFH5.
ExpressionAtlasiA6NFH5. baseline and differential.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031261. FABP12.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF76. PTHR11955:SF76. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis."
    Liu R.Z., Li X., Godbout R.
    Genomics 92:436-445(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Retinoblastoma.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Regulation of human fatty acid binding protein."
    Xiao Y.
    Patent number WO03050280, 19-JUN-2003
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-140.

Entry informationi

Entry nameiFBP12_HUMAN
AccessioniPrimary (citable) accession number: A6NFH5
Secondary accession number(s): B7SUN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.