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Protein

EF-hand calcium-binding domain-containing protein 10

Gene

EFCAB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33314-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 10
Gene namesi
Name:EFCAB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:34531. EFCAB10.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003406801 – 127EF-hand calcium-binding domain-containing protein 10Add BLAST127

Proteomic databases

PaxDbiA6NFE3.
PRIDEiA6NFE3.

Expressioni

Gene expression databases

BgeeiENSG00000185055.
ExpressionAtlasiA6NFE3. baseline and differential.

Organism-specific databases

HPAiHPA019751.

Structurei

3D structure databases

ProteinModelPortaliA6NFE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 98EF-handPROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 1 EF-hand domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J0UR. Eukaryota.
ENOG4111UE3. LUCA.
GeneTreeiENSGT00390000010932.
HOGENOMiHOG000006545.
HOVERGENiHBG108708.
InParanoidiA6NFE3.
PhylomeDBiA6NFE3.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NFE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSSRELQA AEYLEKHQIK EVVSYLTSAL LFFRPEKPKE YLISLLERLR
60 70 80 90 100
IAKVTGVAFP FFMDNSNIVA MFEMMDSSGR GTISFVQYKE ALKTLGLCTE
110 120
DEDLQDDGHK ITLDKFKEEV NKRMKEI
Length:127
Mass (Da):14,721
Last modified:January 15, 2008 - v2
Checksum:i82EC94BBE8F1C84B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073073 Genomic DNA. No translation available.
BC105284 mRNA. No translation available.
UniGeneiHs.719432.

Genome annotation databases

EnsembliENST00000480514; ENSP00000418678; ENSG00000185055.
UCSCiuc003vdb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073073 Genomic DNA. No translation available.
BC105284 mRNA. No translation available.
UniGeneiHs.719432.

3D structure databases

ProteinModelPortaliA6NFE3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA6NFE3.
PRIDEiA6NFE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000480514; ENSP00000418678; ENSG00000185055.
UCSCiuc003vdb.4. human.

Organism-specific databases

GeneCardsiEFCAB10.
HGNCiHGNC:34531. EFCAB10.
HPAiHPA019751.
neXtProtiNX_A6NFE3.
OpenTargetsiENSG00000185055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0UR. Eukaryota.
ENOG4111UE3. LUCA.
GeneTreeiENSGT00390000010932.
HOGENOMiHOG000006545.
HOVERGENiHBG108708.
InParanoidiA6NFE3.
PhylomeDBiA6NFE3.

Enzyme and pathway databases

BioCyciZFISH:G66-33314-MONOMER.

Miscellaneous databases

ChiTaRSiEFCAB10. human.
PROiA6NFE3.

Gene expression databases

BgeeiENSG00000185055.
ExpressionAtlasiA6NFE3. baseline and differential.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFC10_HUMAN
AccessioniPrimary (citable) accession number: A6NFE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.