A6NFC5 (TM235_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 235

Gene names

Name:

TMEM235

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential. Endoplasmic reticulum Probable.
Developmental stage	Not detected before gestational days 53-54. Expressed in the eye at gestational week 10. Ref.3
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family.
Sequence caution	The sequence EAW89517.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW tight junction Inferred from electronic annotation. Source: InterPro
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NFC5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NFC5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     64-91: GQNGCIPLVDPFASESLDVSTSVQHLIL → V

Isoform 3 (identifier: A6NFC5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     65-137: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 223	195	Transmembrane protein 235		PRO_0000406902
Regions
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential
Amino acid modifications
	Glycosylation	41	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	64 – 91	28	GQNGC…QHLIL → V in isoform 2.		VSP_040887
	Alternative sequence	65 – 137	73	Missing in isoform 3.		VSP_040888

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 566E4D43388B9DDF	FASTA	223	23,360
	10 20 30 40 50 60 MARLGALLLA AALGALLSFA LLAAAVASDY WYILEVADAG NGSAWPGRAE LLSSHSGLWR 70 80 90 100 110 120 ICEGQNGCIP LVDPFASESL DVSTSVQHLI LLHRAVIVVL PLSLVLLVCG WICGLLSSLA 130 140 150 160 170 180 QSVSLLLFTG CYFLLGSVLT LAGVSIYISY SHLAFAETVQ QYGPQHMQGV RVSFGWSMAL 190 200 210 220 AWGSCALEAF SGTLLLSAAW TLSLSPPICG HLSPQQVGGR GGD
	Isoform 2 [UniParc]. Checksum: 0F6A9607A17CC3CA	FASTA	196	20,537
	10 20 30 40 50 60 MARLGALLLA AALGALLSFA LLAAAVASDY WYILEVADAG NGSAWPGRAE LLSSHSGLWR 70 80 90 100 110 120 ICEVLHRAVI VVLPLSLVLL VCGWICGLLS SLAQSVSLLL FTGCYFLLGS VLTLAGVSIY 130 140 150 160 170 180 ISYSHLAFAE TVQQYGPQHM QGVRVSFGWS MALAWGSCAL EAFSGTLLLS AAWTLSLSPP 190 ICGHLSPQQV GGRGGD
	Isoform 3 [UniParc]. Checksum: 7AF7F8AB86A4606C	FASTA	150	15,624
	10 20 30 40 50 60 MARLGALLLA AALGALLSFA LLAAAVASDY WYILEVADAG NGSAWPGRAE LLSSHSGLWR 70 80 90 100 110 120 ICEGVLTLAG VSIYISYSHL AFAETVQQYG PQHMQGVRVS FGWSMALAWG SCALEAFSGT 130 140 150 LLLSAAWTLS LSPPICGHLS PQQVGGRGGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-223 (ISOFORM 2).
[3]	"The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members." Maher G.J., Hilton E.N., Urquhart J.E., Davidson A.E., Spencer H.L., Black G.C., Manson F.D. FEBS Lett. 585:2187-2192(2011) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC087645 Genomic DNA. No translation available. CH471099 Genomic DNA. Translation: EAW89517.1. Sequence problems. BC042066 mRNA. No translation available. BM907084 mRNA. No translation available.
IPI	IPI00976859. IPI00982730. IPI01009682.
RefSeq	NP_001191139.1. NM_001204210.1. NP_001191140.1. NM_001204211.1. NP_001191141.1. NM_001204212.1.
UniGene	Hs.632228.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374946; ENSP00000364084; ENSG00000204278. ENST00000421688; ENSP00000402790; ENSG00000204278. ENST00000550981; ENSP00000447766; ENSG00000204278. ENST00000551068; ENSP00000446514; ENSG00000204278. ENST00000586400; ENSP00000466793; ENSG00000204278.
GeneID	283999.
KEGG	hsa:283999.
UCSC	uc002jvk.3. human. uc010dhm.2. human. uc021ued.1. human.
Organism-specific databases
CTD	283999.
GeneCards	GC17P076228.
HGNC	HGNC:27563. TMEM235.
HPA	HPA053939.
neXtProt	NX_A6NFC5.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG317431.
HOVERGEN	HBG076521.
OrthoDB	EOG4DZ1X5.
Gene expression databases
Bgee	A6NFC5.
Genevestigator	A6NFC5.
Family and domain databases
InterPro	IPR006187. Claudin. [Graphical view]
PRINTS	PR01077. CLAUDIN.
PROSITE	PS01221. PMP22_1. False negative. PS01222. PMP22_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	283999.
NextBio	94425.

Entry information

Entry name

TM235_HUMAN

Accession

Primary (citable) accession number: A6NFC5
Secondary accession number(s): C9JRE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 42 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.