OR6C6

Functionⁱ

Odorant receptor.Curated

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 6C6
Gene namesⁱ	Name:OR6C6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

HGNCⁱ	HGNC:31293. OR6C6.

HGNCⁱ

HGNC:31293. OR6C6.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	Length	Description	Actions
Topological domainⁱ	1 – 24	24	ExtracellularSequence analysis	Add BLAST
Transmembraneⁱ	25 – 45	21	Helical; Name=1Sequence analysis	Add BLAST
Topological domainⁱ	46 – 63	18	CytoplasmicSequence analysis	Add BLAST
Transmembraneⁱ	64 – 84	21	Helical; Name=2Sequence analysis	Add BLAST
Topological domainⁱ	85 – 95	11	ExtracellularSequence analysis	Add BLAST
Transmembraneⁱ	96 – 116	21	Helical; Name=3Sequence analysis	Add BLAST
Topological domainⁱ	117 – 141	25	CytoplasmicSequence analysis	Add BLAST
Transmembraneⁱ	142 – 162	21	Helical; Name=4Sequence analysis	Add BLAST
Topological domainⁱ	163 – 199	37	ExtracellularSequence analysis	Add BLAST
Transmembraneⁱ	200 – 220	21	Helical; Name=5Sequence analysis	Add BLAST
Topological domainⁱ	221 – 237	17	CytoplasmicSequence analysis	Add BLAST
Transmembraneⁱ	238 – 258	21	Helical; Name=6Sequence analysis	Add BLAST
Topological domainⁱ	259 – 269	11	ExtracellularSequence analysis	Add BLAST
Transmembraneⁱ	270 – 290	21	Helical; Name=7Sequence analysis	Add BLAST
Topological domainⁱ	291 – 314	24	CytoplasmicSequence analysis	Add BLAST

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA134937223.

PharmGKBⁱ

PA134937223.

Polymorphism and mutation databases

BioMutaⁱ	OR6C6.

BioMutaⁱ

OR6C6.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 314	314	Olfactory receptor 6C6		PRO_0000310457	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Glycosylationⁱ	3 – 3	1	N-linked (GlcNAc...)Sequence analysis
Disulfide bondⁱ	95 ↔ 177		PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00521

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	A6NF89.
PRIDEⁱ	A6NF89.

PTM databases

iPTMnetⁱ	A6NF89.
PhosphoSiteⁱ	A6NF89.

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_OR6C6.

CleanExⁱ

HS_OR6C6.

Organism-specific databases

HPAⁱ	HPA051090.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000351211.

STRINGⁱ

9606.ENSP00000351211.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NF89.
SMRⁱ	A6NF89. Positions 28-314.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFJ6. Eukaryota. ENOG41120HT. LUCA.
GeneTreeⁱ	ENSGT00760000118790.
HOGENOMⁱ	HOG000041364.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	A6NF89.
KOⁱ	K04257.
OMAⁱ	KTIDHFM.
OrthoDBⁱ	EOG091G0F9F.
PhylomeDBⁱ	A6NF89.
TreeFamⁱ	TF336833.

Family and domain databases

InterProⁱ	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

A6NF89-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKNKSMEIEF ILLGLTDDPQ LQIVIFLFLF LNYTLSLMGN LIIIILTLLD 
        60         70         80         90        100
PRLKTPMYFF LRNFSFLEVI FTTVCIPRFL ITIVTRDKTI SYNNCATQLF 
       110        120        130        140        150
FILLPGVTEF YLLAAMSYDR YVAICKPLHY PIIMSSKVCY QLVLSSWVTG 
       160        170        180        190        200
FLIIFPPLVM GLKLDFCASK TIDHFMCETS PILQISCTDT HVLELMSFTL 
       210        220        230        240        250
AVVTLVVTLV LVILSYTCII KTILKFSSAQ QRNKAFSTCT SHMIVVSMTY 
       260        270        280        290        300
GSCIFMYIKP SAKERVTVSK GVALLYTSIA PLLNPFIYTL RNQQVKEVFW 
       310 
DVLQKNLCFS KRPF

Length:314

Mass (Da):35,963

Last modified:July 24, 2007 - v1

Checksum:ⁱ6779A4F9B12D1279

GO

Natural variant

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Natural variantⁱ	190 – 190	1	T → I. Corresponds to variant rs11171402 [ dbSNP \| Ensembl ].		VAR_037048

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC122684 Genomic DNA. No translation available.
CCDSⁱ	CCDS31817.1.
RefSeqⁱ	NP_001005493.1. NM_001005493.1.
UniGeneⁱ	Hs.554555.

Genome annotation databases

Ensemblⁱ	ENST00000358433; ENSP00000351211; ENSG00000188324.
GeneIDⁱ	283365.
KEGGⁱ	hsa:283365.
UCSCⁱ	uc010sph.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC122684 Genomic DNA. No translation available.
CCDSⁱ	CCDS31817.1.
RefSeqⁱ	NP_001005493.1. NM_001005493.1.
UniGeneⁱ	Hs.554555.

3D structure databases

ProteinModelPortalⁱ	A6NF89.
SMRⁱ	A6NF89. Positions 28-314.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000351211.

STRINGⁱ

9606.ENSP00000351211.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	A6NF89.
PhosphoSiteⁱ	A6NF89.

Polymorphism and mutation databases

BioMutaⁱ	OR6C6.

BioMutaⁱ

OR6C6.

Proteomic databases

PaxDbⁱ	A6NF89.
PRIDEⁱ	A6NF89.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000358433; ENSP00000351211; ENSG00000188324.
GeneIDⁱ	283365.
KEGGⁱ	hsa:283365.
UCSCⁱ	uc010sph.2. human.

Organism-specific databases

CTDⁱ	283365.
GeneCardsⁱ	OR6C6.
HGNCⁱ	HGNC:31293. OR6C6.
HPAⁱ	HPA051090.
neXtProtⁱ	NX_A6NF89.
PharmGKBⁱ	PA134937223.
GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFJ6. Eukaryota. ENOG41120HT. LUCA.
GeneTreeⁱ	ENSGT00760000118790.
HOGENOMⁱ	HOG000041364.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	A6NF89.
KOⁱ	K04257.
OMAⁱ	KTIDHFM.
OrthoDBⁱ	EOG091G0F9F.
PhylomeDBⁱ	A6NF89.
TreeFamⁱ	TF336833.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAiⁱ	283365.
PROⁱ	A6NF89.

Gene expression databases

CleanExⁱ	HS_OR6C6.

CleanExⁱ

HS_OR6C6.

Family and domain databases

InterProⁱ	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

OR6C6_HUMAN

Accessionⁱ

Primary (citable) accession number: A6NF89

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	July 24, 2007
Last modified:	September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A6NF89 (OR6C6_HUMAN)

UniProt

A6NF89 - OR6C6_HUMAN

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Olfactory receptor 6C6

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>Provides links to various web resources that are relevant for a specific protein.</p><p><a href='../manual/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ