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Protein

Olfactory receptor 6C6

Gene

OR6C6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C6
Gene namesi
Name:OR6C6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:31293. OR6C6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini46 – 6318CytoplasmicSequence analysisAdd
BLAST
Transmembranei64 – 8421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini85 – 9511ExtracellularSequence analysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini117 – 14125CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19937ExtracellularSequence analysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 31424CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937223.

Polymorphism and mutation databases

BioMutaiOR6C6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 6C6PRO_0000310457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NF89.
PRIDEiA6NF89.

PTM databases

iPTMnetiA6NF89.

Expressioni

Gene expression databases

CleanExiHS_OR6C6.

Organism-specific databases

HPAiHPA051090.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351211.

Structurei

3D structure databases

ProteinModelPortaliA6NF89.
SMRiA6NF89. Positions 28-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJ6. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NF89.
KOiK04257.
OMAiKTIDHFM.
OrthoDBiEOG7KH9K8.
PhylomeDBiA6NF89.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NF89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKSMEIEF ILLGLTDDPQ LQIVIFLFLF LNYTLSLMGN LIIIILTLLD
60 70 80 90 100
PRLKTPMYFF LRNFSFLEVI FTTVCIPRFL ITIVTRDKTI SYNNCATQLF
110 120 130 140 150
FILLPGVTEF YLLAAMSYDR YVAICKPLHY PIIMSSKVCY QLVLSSWVTG
160 170 180 190 200
FLIIFPPLVM GLKLDFCASK TIDHFMCETS PILQISCTDT HVLELMSFTL
210 220 230 240 250
AVVTLVVTLV LVILSYTCII KTILKFSSAQ QRNKAFSTCT SHMIVVSMTY
260 270 280 290 300
GSCIFMYIKP SAKERVTVSK GVALLYTSIA PLLNPFIYTL RNQQVKEVFW
310
DVLQKNLCFS KRPF
Length:314
Mass (Da):35,963
Last modified:July 24, 2007 - v1
Checksum:i6779A4F9B12D1279
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901T → I.
Corresponds to variant rs11171402 [ dbSNP | Ensembl ].
VAR_037048

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA. No translation available.
CCDSiCCDS31817.1.
RefSeqiNP_001005493.1. NM_001005493.1.
UniGeneiHs.554555.

Genome annotation databases

EnsembliENST00000358433; ENSP00000351211; ENSG00000188324.
GeneIDi283365.
KEGGihsa:283365.
UCSCiuc010sph.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA. No translation available.
CCDSiCCDS31817.1.
RefSeqiNP_001005493.1. NM_001005493.1.
UniGeneiHs.554555.

3D structure databases

ProteinModelPortaliA6NF89.
SMRiA6NF89. Positions 28-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351211.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NF89.

Polymorphism and mutation databases

BioMutaiOR6C6.

Proteomic databases

PaxDbiA6NF89.
PRIDEiA6NF89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358433; ENSP00000351211; ENSG00000188324.
GeneIDi283365.
KEGGihsa:283365.
UCSCiuc010sph.2. human.

Organism-specific databases

CTDi283365.
GeneCardsiOR6C6.
HGNCiHGNC:31293. OR6C6.
HPAiHPA051090.
neXtProtiNX_A6NF89.
PharmGKBiPA134937223.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJ6. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NF89.
KOiK04257.
OMAiKTIDHFM.
OrthoDBiEOG7KH9K8.
PhylomeDBiA6NF89.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii283365.
PROiA6NF89.

Gene expression databases

CleanExiHS_OR6C6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR6C6_HUMAN
AccessioniPrimary (citable) accession number: A6NF89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.