OR6C6

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: InterPro

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 6C6
Gene namesⁱ	Name:OR6C6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31293. OR6C6.

HGNCⁱ

HGNC:31293. OR6C6.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 24	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	25 – 45	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	46 – 63	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	64 – 84	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	85 – 95	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	96 – 116	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	117 – 141	CytoplasmicSequence analysisAdd BLAST	25
Transmembraneⁱ	142 – 162	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	163 – 199	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	200 – 220	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	221 – 237	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	238 – 258	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	259 – 269	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	270 – 290	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	291 – 314	CytoplasmicSequence analysisAdd BLAST	24

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA134937223.

PharmGKBⁱ

PA134937223.

Polymorphism and mutation databases

BioMutaⁱ	OR6C6.

BioMutaⁱ

OR6C6.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000310457	1 – 314	Olfactory receptor 6C6Add BLAST		314

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	3	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	95 ↔ 177	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	A6NF89.
PRIDEⁱ	A6NF89.

PTM databases

iPTMnetⁱ	A6NF89.
PhosphoSitePlusⁱ	A6NF89.

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_OR6C6.
ExpressionAtlasⁱ	A6NF89. baseline and differential.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051090.

HPAⁱ

HPA051090.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000351211.

STRINGⁱ

9606.ENSP00000351211.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NF89.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFJ6. Eukaryota. ENOG41120HT. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118790.
HOGENOMⁱ	HOG000041364.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	A6NF89.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	KTIDHFM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F9F.
PhylomeDBⁱ	A6NF89.
TreeFamⁱ	TF336833.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A6NF89-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKNKSMEIEF ILLGLTDDPQ LQIVIFLFLF LNYTLSLMGN LIIIILTLLD 
        60         70         80         90        100
PRLKTPMYFF LRNFSFLEVI FTTVCIPRFL ITIVTRDKTI SYNNCATQLF 
       110        120        130        140        150
FILLPGVTEF YLLAAMSYDR YVAICKPLHY PIIMSSKVCY QLVLSSWVTG 
       160        170        180        190        200
FLIIFPPLVM GLKLDFCASK TIDHFMCETS PILQISCTDT HVLELMSFTL 
       210        220        230        240        250
AVVTLVVTLV LVILSYTCII KTILKFSSAQ QRNKAFSTCT SHMIVVSMTY 
       260        270        280        290        300
GSCIFMYIKP SAKERVTVSK GVALLYTSIA PLLNPFIYTL RNQQVKEVFW 
       310 
DVLQKNLCFS KRPF

Length:314

Mass (Da):35,963

Last modified:July 24, 2007 - v1

Checksum:ⁱ6779A4F9B12D1279

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_037048	190	T → I. Corresponds to variant dbSNP:rs11171402Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC122684 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31817.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001005493.1. NM_001005493.1.
UniGeneⁱ	Hs.554555.

Genome annotation databases

Ensemblⁱ	ENST00000358433; ENSP00000351211; ENSG00000188324.
GeneIDⁱ	283365.
KEGGⁱ	hsa:283365.
UCSC genome browser More...UCSCⁱ	uc010sph.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A6NF89	A0A126GW15	Homo sapiens (Human)	314	UniRef100_A6NF89	Cluster: Olfactory receptor 6C6	2

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A6NF89	A0A126GW15 H2R7F5 A0A1U7TQ83 UPI0001D376B9 UPI00027435AD UPI0002C63A4D UPI0003C8CB9D UPI0004BDF06B UPI0004D08886 UPI000626DD97 +8	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Tarsius syrichta (Philippine tarsier) Callithrix jacchus (White-tufted-ear marmoset) Pan paniscus (Pygmy chimpanzee) (Bonobo) Ceratotherium simum simum (southern white rhinoceros) Tupaia chinensis (Chinese tree shrew) Equus przewalskii (Przewalski's horse) (Equus caballus przewalskii) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Aotus nancymaae (Ma's night monkey) And more	314	UniRef90_A6NF89	Cluster: Olfactory receptor 6C6	19

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A6NF89	Q9Z1V0 D3ZAT2 UPI000A307175 UPI00038C069B UPI000A3198D7 UPI00042ACB57 F7F647 F6W387 G3UF67 UPI0002233516 +2118	Mus musculus (Mouse) Rattus norvegicus (Rat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Microtus ochrogaster (Prairie vole) Mus caroli (Ryukyu mouse) (Ricefield mouse) Peromyscus maniculatus bairdii (prairie deer mouse) Monodelphis domestica (Gray short-tailed opossum) Loxodonta africana (African elephant) Jaculus jaculus (Lesser Egyptian jerboa) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) And more	313	UniRef50_Q9Z1V0	Cluster: Olfactory receptor 49	2,129

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC122684 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31817.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001005493.1. NM_001005493.1.
UniGeneⁱ	Hs.554555.

3D structure databases

ProteinModelPortalⁱ	A6NF89.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000351211.

STRINGⁱ

9606.ENSP00000351211.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	A6NF89.
PhosphoSitePlusⁱ	A6NF89.

Polymorphism and mutation databases

BioMutaⁱ	OR6C6.

BioMutaⁱ

OR6C6.

Proteomic databases

PaxDbⁱ	A6NF89.
PRIDEⁱ	A6NF89.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000358433; ENSP00000351211; ENSG00000188324.
GeneIDⁱ	283365.
KEGGⁱ	hsa:283365.
UCSC genome browser More...UCSCⁱ	uc010sph.2. human.

Organism-specific databases

CTDⁱ	283365.
GeneCardsⁱ	OR6C6.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31293. OR6C6.
Human Protein Atlas More...HPAⁱ	HPA051090.
neXtProtⁱ	NX_A6NF89.
PharmGKBⁱ	PA134937223.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFJ6. Eukaryota. ENOG41120HT. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118790.
HOGENOMⁱ	HOG000041364.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	A6NF89.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	KTIDHFM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F9F.
PhylomeDBⁱ	A6NF89.
TreeFamⁱ	TF336833.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAiⁱ	283365.
Protein Ontology More...PROⁱ	PR:A6NF89.

Gene expression databases

CleanExⁱ	HS_OR6C6.
ExpressionAtlasⁱ	A6NF89. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OR6C6_HUMAN
Accessionⁱ	A6NF89Primary (citable) accession number: A6NF89
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	July 24, 2007
	Last modified:	August 30, 2017
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A6NF89 (OR6C6_HUMAN)

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Olfactory receptor 6C6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ