ID   CC182_HUMAN             Reviewed;         153 AA.
AC   A6NF36;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 89.
DE   RecName: Full=Coiled-coil domain-containing protein 182;
GN   Name=CCDC182;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DA205423; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC005325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471109; EAW94504.1; -; Genomic_DNA.
DR   CCDS; CCDS62263.1; -.
DR   RefSeq; NP_001269473.1; NM_001282544.1.
DR   AlphaFoldDB; A6NF36; -.
DR   SMR; A6NF36; -.
DR   IntAct; A6NF36; 1.
DR   STRING; 9606.ENSP00000299415; -.
DR   BioMuta; CCDC182; -.
DR   MassIVE; A6NF36; -.
DR   MaxQB; A6NF36; -.
DR   PaxDb; 9606-ENSP00000299415; -.
DR   PeptideAtlas; A6NF36; -.
DR   Antibodypedia; 21057; 49 antibodies from 11 providers.
DR   DNASU; 101927581; -.
DR   Ensembl; ENST00000299415.3; ENSP00000299415.2; ENSG00000166329.3.
DR   GeneID; 101927581; -.
DR   KEGG; hsa:101927581; -.
DR   MANE-Select; ENST00000299415.3; ENSP00000299415.2; NM_001282544.2; NP_001269473.1.
DR   UCSC; uc032fnr.2; human.
DR   AGR; HGNC:49392; -.
DR   CTD; 101927581; -.
DR   GeneCards; CCDC182; -.
DR   HGNC; HGNC:49392; CCDC182.
DR   HPA; ENSG00000166329; Tissue enriched (testis).
DR   neXtProt; NX_A6NF36; -.
DR   OpenTargets; ENSG00000166329; -.
DR   VEuPathDB; HostDB:ENSG00000166329; -.
DR   eggNOG; ENOG502SV1I; Eukaryota.
DR   GeneTree; ENSGT00390000014787; -.
DR   HOGENOM; CLU_144243_0_0_1; -.
DR   InParanoid; A6NF36; -.
DR   OMA; YCEMSRT; -.
DR   OrthoDB; 4820434at2759; -.
DR   PhylomeDB; A6NF36; -.
DR   BioGRID-ORCS; 101927581; 6 hits in 893 CRISPR screens.
DR   GenomeRNAi; 101927581; -.
DR   Pharos; A6NF36; Tdark.
DR   PRO; PR:A6NF36; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; A6NF36; Protein.
DR   Bgee; ENSG00000166329; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 30 other cell types or tissues.
DR   GO; GO:0008585; P:female gonad development; ISS:UniProtKB.
DR   InterPro; IPR031678; DUF4715.
DR   PANTHER; PTHR37364; COILED-COIL DOMAIN-CONTAINING PROTEIN 182; 1.
DR   PANTHER; PTHR37364:SF1; COILED-COIL DOMAIN-CONTAINING PROTEIN 182; 1.
DR   Pfam; PF15835; DUF4715; 1.
DR   Genevisible; A6NF36; HS.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..153
FT                   /note="Coiled-coil domain-containing protein 182"
FT                   /id="PRO_0000329034"
FT   COILED          46..109
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17536 MW;  A80AA5055790DB52 CRC64;
     MEPLYQAGSI LMTVNTLQGK KMIESGLQSG DFSLSQSWPS CLPPPADLEI LQQKVAGVQR
     ELEDFKKEAL KSIHYLEDAF CEMNGALVQQ EEQAARVRQR LREEEDRGIV RNKVLTFLLP
     REKQLREHCK RLEDLLLDRG RDALRATKKS QAD
//