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A6NET4 (OR5K3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5K3
Gene names
Name:OR5K3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Olfactory receptor 5K3
PRO_0000310455

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 5610Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 9720Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 14325Cytoplasmic Potential
Transmembrane144 – 16421Helical; Name=4; Potential
Topological domain165 – 19632Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23518Cytoplasmic Potential
Transmembrane236 – 25621Helical; Name=6; Potential
Topological domain257 – 26913Extracellular Potential
Transmembrane270 – 29021Helical; Name=7; Potential
Topological domain291 – 32131Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 179 By similarity

Natural variations

Natural variant441G → D.
Corresponds to variant rs13068323 [ dbSNP | Ensembl ].
VAR_037044

Sequences

Sequence LengthMass (Da)Tools
A6NET4 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 812EDD08376360A7

FASTA32136,711
        10         20         30         40         50         60 
MNKENHSLIA EFILTGFTYH PKLKTVLFVV FFAIYLITMV GNIGLVALIY IEQRLHTPMY 

        70         80         90        100        110        120 
IFLGNLVLMD SCCSSAITPK MLENFFSEDK RITLYECMAQ FYFLCLAETT DCFLLAAMAY 

       130        140        150        160        170        180 
DCYVAICNPL QYHTMMSKTL CIQMTAGAYL AGNLHPMIEV EFLLRLTFCG SHQINHFFCD 

       190        200        210        220        230        240 
VLPLYRLSCI NPYINELVLF ILAGSIQIFT IVLVSYFYIL FTIFTMKSKE GRGKALSTCA 

       250        260        270        280        290        300 
SHFLSVSIFC DSLLFMYARP GAVNEGDKDI PVAIFYTLVI PLLNPFIYSL RNKEVINIMK 

       310        320 
KIMKKRKFCH ILKQMSSPLA T 

« Hide

References

[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC108730 Genomic DNA. No translation available.
CCDSCCDS33803.1.
RefSeqNP_001005516.1. NM_001005516.1.
UniGeneHs.554709.

3D structure databases

ProteinModelPortalA6NET4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000373194.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEA6NET4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000383695; ENSP00000373194; ENSG00000206536.
GeneID403277.
KEGGhsa:403277.
UCSCuc011bgw.2. human.

Organism-specific databases

CTD403277.
GeneCardsGC03P098110.
HGNCHGNC:31290. OR5K3.
neXtProtNX_A6NET4.
PharmGKBPA134984948.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44330.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidA6NET4.
KOK04257.
OMARITLYEC.
OrthoDBEOG7DFXCK.
PhylomeDBA6NET4.
TreeFamTF352737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5K3.
GenevestigatorA6NET4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi403277.
NextBio107709.
PROA6NET4.

Entry information

Entry nameOR5K3_HUMAN
AccessionPrimary (citable) accession number: A6NET4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries