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A6NET4

- OR5K3_HUMAN

UniProt

A6NET4 - OR5K3_HUMAN

Protein

Olfactory receptor 5K3

Gene

OR5K3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5K3
    Gene namesi
    Name:OR5K3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:31290. OR5K3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134984948.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Olfactory receptor 5K3PRO_0000310455Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiA6NET4.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5K3.
    GenevestigatoriA6NET4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000373194.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NET4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 5610CytoplasmicSequence Analysis
    Topological domaini78 – 9720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 14325CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 19632ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23518CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 32131CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44330.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiA6NET4.
    KOiK04257.
    OMAiRITLYEC.
    OrthoDBiEOG7DFXCK.
    PhylomeDBiA6NET4.
    TreeFamiTF352737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NET4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKENHSLIA EFILTGFTYH PKLKTVLFVV FFAIYLITMV GNIGLVALIY    50
    IEQRLHTPMY IFLGNLVLMD SCCSSAITPK MLENFFSEDK RITLYECMAQ 100
    FYFLCLAETT DCFLLAAMAY DCYVAICNPL QYHTMMSKTL CIQMTAGAYL 150
    AGNLHPMIEV EFLLRLTFCG SHQINHFFCD VLPLYRLSCI NPYINELVLF 200
    ILAGSIQIFT IVLVSYFYIL FTIFTMKSKE GRGKALSTCA SHFLSVSIFC 250
    DSLLFMYARP GAVNEGDKDI PVAIFYTLVI PLLNPFIYSL RNKEVINIMK 300
    KIMKKRKFCH ILKQMSSPLA T 321
    Length:321
    Mass (Da):36,711
    Last modified:July 24, 2007 - v1
    Checksum:i812EDD08376360A7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441G → D.
    Corresponds to variant rs13068323 [ dbSNP | Ensembl ].
    VAR_037044

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC108730 Genomic DNA. No translation available.
    CCDSiCCDS33803.1.
    RefSeqiNP_001005516.1. NM_001005516.1.
    UniGeneiHs.554709.

    Genome annotation databases

    EnsembliENST00000383695; ENSP00000373194; ENSG00000206536.
    GeneIDi403277.
    KEGGihsa:403277.
    UCSCiuc011bgw.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC108730 Genomic DNA. No translation available.
    CCDSi CCDS33803.1.
    RefSeqi NP_001005516.1. NM_001005516.1.
    UniGenei Hs.554709.

    3D structure databases

    ProteinModelPortali A6NET4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000373194.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi A6NET4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383695 ; ENSP00000373194 ; ENSG00000206536 .
    GeneIDi 403277.
    KEGGi hsa:403277.
    UCSCi uc011bgw.2. human.

    Organism-specific databases

    CTDi 403277.
    GeneCardsi GC03P098110.
    HGNCi HGNC:31290. OR5K3.
    neXtProti NX_A6NET4.
    PharmGKBi PA134984948.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44330.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi A6NET4.
    KOi K04257.
    OMAi RITLYEC.
    OrthoDBi EOG7DFXCK.
    PhylomeDBi A6NET4.
    TreeFami TF352737.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GenomeRNAii 403277.
    NextBioi 107709.
    PROi A6NET4.

    Gene expression databases

    CleanExi HS_OR5K3.
    Genevestigatori A6NET4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiOR5K3_HUMAN
    AccessioniPrimary (citable) accession number: A6NET4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3