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A6NET4

- OR5K3_HUMAN

UniProt

A6NET4 - OR5K3_HUMAN

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Protein

Olfactory receptor 5K3

Gene

OR5K3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5K3
Gene namesi
Name:OR5K3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:31290. OR5K3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984948.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 5K3PRO_0000310455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA6NET4.

Expressioni

Gene expression databases

CleanExiHS_OR5K3.
GenevestigatoriA6NET4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000373194.

Structurei

3D structure databases

ProteinModelPortaliA6NET4.
SMRiA6NET4. Positions 109-140.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini47 – 5610CytoplasmicSequence Analysis
Topological domaini78 – 9720ExtracellularSequence AnalysisAdd
BLAST
Topological domaini119 – 14325CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini165 – 19632ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23518CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini257 – 26913ExtracellularSequence AnalysisAdd
BLAST
Topological domaini291 – 32131CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44330.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NET4.
KOiK04257.
OMAiRITLYEC.
OrthoDBiEOG7DFXCK.
PhylomeDBiA6NET4.
TreeFamiTF352737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NET4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKENHSLIA EFILTGFTYH PKLKTVLFVV FFAIYLITMV GNIGLVALIY
60 70 80 90 100
IEQRLHTPMY IFLGNLVLMD SCCSSAITPK MLENFFSEDK RITLYECMAQ
110 120 130 140 150
FYFLCLAETT DCFLLAAMAY DCYVAICNPL QYHTMMSKTL CIQMTAGAYL
160 170 180 190 200
AGNLHPMIEV EFLLRLTFCG SHQINHFFCD VLPLYRLSCI NPYINELVLF
210 220 230 240 250
ILAGSIQIFT IVLVSYFYIL FTIFTMKSKE GRGKALSTCA SHFLSVSIFC
260 270 280 290 300
DSLLFMYARP GAVNEGDKDI PVAIFYTLVI PLLNPFIYSL RNKEVINIMK
310 320
KIMKKRKFCH ILKQMSSPLA T
Length:321
Mass (Da):36,711
Last modified:July 24, 2007 - v1
Checksum:i812EDD08376360A7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441G → D.
Corresponds to variant rs13068323 [ dbSNP | Ensembl ].
VAR_037044

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC108730 Genomic DNA. No translation available.
CCDSiCCDS33803.1.
RefSeqiNP_001005516.1. NM_001005516.1.
UniGeneiHs.554709.

Genome annotation databases

EnsembliENST00000383695; ENSP00000373194; ENSG00000206536.
GeneIDi403277.
KEGGihsa:403277.
UCSCiuc011bgw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC108730 Genomic DNA. No translation available.
CCDSi CCDS33803.1.
RefSeqi NP_001005516.1. NM_001005516.1.
UniGenei Hs.554709.

3D structure databases

ProteinModelPortali A6NET4.
SMRi A6NET4. Positions 109-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000373194.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi A6NET4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000383695 ; ENSP00000373194 ; ENSG00000206536 .
GeneIDi 403277.
KEGGi hsa:403277.
UCSCi uc011bgw.2. human.

Organism-specific databases

CTDi 403277.
GeneCardsi GC03P098110.
HGNCi HGNC:31290. OR5K3.
neXtProti NX_A6NET4.
PharmGKBi PA134984948.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44330.
GeneTreei ENSGT00550000074564.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi A6NET4.
KOi K04257.
OMAi RITLYEC.
OrthoDBi EOG7DFXCK.
PhylomeDBi A6NET4.
TreeFami TF352737.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 403277.
NextBioi 107709.
PROi A6NET4.

Gene expression databases

CleanExi HS_OR5K3.
Genevestigatori A6NET4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR5K3_HUMAN
AccessioniPrimary (citable) accession number: A6NET4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3