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Protein

Olfactory receptor 5K3

Gene

OR5K3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32029-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5K3
Gene namesi
Name:OR5K3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31290. OR5K3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 56CytoplasmicSequence analysis10
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 97ExtracellularSequence analysisAdd BLAST20
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 143CytoplasmicSequence analysisAdd BLAST25
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 196ExtracellularSequence analysisAdd BLAST32
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 235CytoplasmicSequence analysisAdd BLAST18
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 321CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000206536.
PharmGKBiPA134984948.

Polymorphism and mutation databases

BioMutaiOR5K3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104551 – 321Olfactory receptor 5K3Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NET4.
PRIDEiA6NET4.

Expressioni

Gene expression databases

CleanExiHS_OR5K3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000373194.

Structurei

3D structure databases

ProteinModelPortaliA6NET4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9MS. Eukaryota.
ENOG41116R8. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NET4.
KOiK04257.
OMAiIQMTAGA.
OrthoDBiEOG091G0AZH.
PhylomeDBiA6NET4.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NET4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKENHSLIA EFILTGFTYH PKLKTVLFVV FFAIYLITMV GNIGLVALIY
60 70 80 90 100
IEQRLHTPMY IFLGNLVLMD SCCSSAITPK MLENFFSEDK RITLYECMAQ
110 120 130 140 150
FYFLCLAETT DCFLLAAMAY DCYVAICNPL QYHTMMSKTL CIQMTAGAYL
160 170 180 190 200
AGNLHPMIEV EFLLRLTFCG SHQINHFFCD VLPLYRLSCI NPYINELVLF
210 220 230 240 250
ILAGSIQIFT IVLVSYFYIL FTIFTMKSKE GRGKALSTCA SHFLSVSIFC
260 270 280 290 300
DSLLFMYARP GAVNEGDKDI PVAIFYTLVI PLLNPFIYSL RNKEVINIMK
310 320
KIMKKRKFCH ILKQMSSPLA T
Length:321
Mass (Da):36,711
Last modified:July 24, 2007 - v1
Checksum:i812EDD08376360A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03704444G → D.Corresponds to variant rs13068323dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108730 Genomic DNA. No translation available.
CCDSiCCDS33803.1.
RefSeqiNP_001005516.1. NM_001005516.1.
UniGeneiHs.554709.

Genome annotation databases

EnsembliENST00000383695; ENSP00000373194; ENSG00000206536.
GeneIDi403277.
KEGGihsa:403277.
UCSCiuc011bgw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108730 Genomic DNA. No translation available.
CCDSiCCDS33803.1.
RefSeqiNP_001005516.1. NM_001005516.1.
UniGeneiHs.554709.

3D structure databases

ProteinModelPortaliA6NET4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000373194.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5K3.

Proteomic databases

PaxDbiA6NET4.
PRIDEiA6NET4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383695; ENSP00000373194; ENSG00000206536.
GeneIDi403277.
KEGGihsa:403277.
UCSCiuc011bgw.2. human.

Organism-specific databases

CTDi403277.
GeneCardsiOR5K3.
HGNCiHGNC:31290. OR5K3.
neXtProtiNX_A6NET4.
OpenTargetsiENSG00000206536.
PharmGKBiPA134984948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9MS. Eukaryota.
ENOG41116R8. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NET4.
KOiK04257.
OMAiIQMTAGA.
OrthoDBiEOG091G0AZH.
PhylomeDBiA6NET4.
TreeFamiTF352737.

Enzyme and pathway databases

BioCyciZFISH:G66-32029-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii403277.
PROiA6NET4.

Gene expression databases

CleanExiHS_OR5K3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5K3_HUMAN
AccessioniPrimary (citable) accession number: A6NET4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.