ID   CX065_HUMAN             Reviewed;         183 AA.
AC   A6NEN9;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=Uncharacterized protein CXorf65;
GN   Name=CXorf65;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AL590764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471132; EAX05320.1; -; Genomic_DNA.
DR   CCDS; CCDS35324.1; -.
DR   RefSeq; NP_001020436.1; NM_001025265.2.
DR   AlphaFoldDB; A6NEN9; -.
DR   STRING; 9606.ENSP00000363369; -.
DR   iPTMnet; A6NEN9; -.
DR   PhosphoSitePlus; A6NEN9; -.
DR   BioMuta; CXorf65; -.
DR   MassIVE; A6NEN9; -.
DR   PaxDb; 9606-ENSP00000363369; -.
DR   PeptideAtlas; A6NEN9; -.
DR   ProteomicsDB; 997; -.
DR   Antibodypedia; 67487; 5 antibodies from 5 providers.
DR   DNASU; 158830; -.
DR   Ensembl; ENST00000374251.6; ENSP00000363369.4; ENSG00000204165.6.
DR   GeneID; 158830; -.
DR   KEGG; hsa:158830; -.
DR   MANE-Select; ENST00000374251.6; ENSP00000363369.4; NM_001025265.3; NP_001020436.1.
DR   UCSC; uc011mpo.3; human.
DR   AGR; HGNC:33713; -.
DR   CTD; 158830; -.
DR   DisGeNET; 158830; -.
DR   GeneCards; CXorf65; -.
DR   HGNC; HGNC:33713; CXorf65.
DR   HPA; ENSG00000204165; Tissue enriched (testis).
DR   neXtProt; NX_A6NEN9; -.
DR   OpenTargets; ENSG00000204165; -.
DR   PharmGKB; PA164718500; -.
DR   VEuPathDB; HostDB:ENSG00000204165; -.
DR   eggNOG; ENOG502S153; Eukaryota.
DR   GeneTree; ENSGT00510000049291; -.
DR   HOGENOM; CLU_126634_0_0_1; -.
DR   InParanoid; A6NEN9; -.
DR   OMA; PGDYANK; -.
DR   OrthoDB; 1327631at2759; -.
DR   PhylomeDB; A6NEN9; -.
DR   TreeFam; TF328811; -.
DR   PathwayCommons; A6NEN9; -.
DR   SignaLink; A6NEN9; -.
DR   BioGRID-ORCS; 158830; 7 hits in 763 CRISPR screens.
DR   ChiTaRS; CXorf65; human.
DR   GenomeRNAi; 158830; -.
DR   Pharos; A6NEN9; Tdark.
DR   PRO; PR:A6NEN9; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; A6NEN9; Protein.
DR   Bgee; ENSG00000204165; Expressed in granulocyte and 87 other cell types or tissues.
DR   ExpressionAtlas; A6NEN9; baseline and differential.
DR   InterPro; IPR039471; CXorf65-like.
DR   PANTHER; PTHR33887:SF4; AB2-183; 1.
DR   PANTHER; PTHR33887; COILIN; 1.
DR   Pfam; PF15874; Il2rg; 1.
DR   Genevisible; A6NEN9; HS.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..183
FT                   /note="Uncharacterized protein CXorf65"
FT                   /id="PRO_0000346434"
FT   REGION          136..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         156
FT                   /note="R -> H (in dbSNP:rs12009522)"
FT                   /id="VAR_045896"
SQ   SEQUENCE   183 AA;  21305 MW;  CCC8209694661532 CRC64;
     MFIFIKHGDN QQFLVNTNCA VVVLLYYIRS KVKLPKTNTI DLCEQTGKMK MLFLMKPNHA
     EYASKYLTAR STYYVCKVER GPPGTRLENA YRAFVPLLKN PEPWLLVALR IQCDALERRR
     IQMLKMKEAK KVVIIEPPAS VPSKQSGRSD KKKSTRKSPT FRNRPDFRKN KGRQLNKTTK
     QKK
//