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A6NEM2

- A6NEM2_HUMAN

UniProt

A6NEM2 - A6NEM2_HUMAN

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Protein
Submitted name:

HCF N-terminal chain 5

Gene
HCFC1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
HCF N-terminal chain 5Imported
Gene namesi
Name:HCFC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:4839. HCFC1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiA6NEM2.
PRIDEiA6NEM2.

Expressioni

Gene expression databases

ArrayExpressiA6NEM2.
BgeeiA6NEM2.

Structurei

3D structure databases

ProteinModelPortaliA6NEM2.
SMRiA6NEM2. Positions 360-400, 1856-2055.

Family & Domainsi

Keywords - Domaini

Kelch repeatSAAS annotations

Phylogenomic databases

HOGENOMiHOG000293192.
HOVERGENiHBG051888.
KOiK14966.
OMAiNGHNEMA.
OrthoDBiEOG790G05.
PhylomeDBiA6NEM2.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NEM2-1 [UniParc]FASTAAdd to Basket

« Hide

MASAVSPANL PAVLLQPRWK RVVGWSGPVP RPRHGHRAVA IKELIVVFGG     50
GNEGIVDELH VYNTATNQWF IPAVRGDIPP GCAAYGFVCD GTRLLVFGGM 100
VEYGKYSNDL YELQASRWEW KRLKAKTPKN GPPPCPRLGH SFSLVGNKCY 150
LFGGLANDSE DPKNNIPRYL NDLYILELRP GSGVVAWDIP ITYGVLPPPR 200
ESHTAVVYTE KDNKKSKLVI YGGMSGCRLG DLWTLDIDTL TWNKPSLSGV 250
APLPRSLHSA TTIGNKMYVF GGWVPLVMDD VKVATHEKEW KCTNTLACLN 300
LDTMAWETIL MDTLEDNIPR ARAGHCAVAI NTRLYIWSGR DGYRKAWNNQ 350
VCCKDLWYLE TEKPPPPARV QLVRANTNSL EVSWGAVATA DSYLLQLQKY 400
DIPATAATAT SPTPNPVPSV PANPPKSPAP AAAAPAVQPL TQVGITLLPQ 450
AAPAPPTTTT IQVLPTVPGS SISVPTAART QGVPAVLKVT GPQATTGTPL 500
VTMRPASQAG KAPVTVTSLP AGVRMVVPTQ SAQGTVIGSS PQMSGMAALA 550
AAAAATQKIP PSSAPTVLSV PAGTTIVKTM AVTPGTTTLP ATVKVASSPV 600
MVSNPATRML KTAAAQVGTS VSSATNTSTR PIITVHKSGT VTVAQQAQVV 650
TTVVGGVTKT ITLVKSPISV PGGSALISNL GKVMSVVQTK PVQTSAVTGQ 700
ASTGPVTQII QTKGPLPAGT ILKLVTSADG KPTTIITTTQ ASGAGTKPTI 750
LGISSVSPST TKPGTTTIIK TIPMSAIITQ AGATGVTSSP GIKSPITIIT 800
TKVMTSGTGA PAKIITAVPK IATGHGQQGV TQVVLKGAPG QPGTILRTVP 850
MGGVRLVTPV TVSAVKPAVT TLVVKGTTGV TTLGTVTGTV STSLAGAGGH 900
STSASLATPI TTLGTIATLS SQVINPTAIT VSAAQTTLTA AGGLTTPTIT 950
MQPVSQPTQV TLITAPSGVE AQPVHDLPVS ILASPTTEQP TATVTIADSG 1000
QGDVQPGTVT LVCSNPPCET HETGTTNTAT TTVVANLGGH PQPTQVQFVC 1050
DRQEAAASLV TSTVGQQNGS VVRVCSNPPC ETHETGTTNT ATTATSNMAG 1100
QHGCSNPPCE THETGTTNTA TTAMSSVGAN HQRDARRACA AGTPAVIRIS 1150
VATGALEAAQ GSKSQCQTRQ TSATSTTMTV MATGAPCSAG PLLGPSMARE 1200
PGGRSPAFVQ LAPLSSKVRL SSPSIKDLPA GRHSHAVSTA AMTRSSVGAG 1250
EPRMAPVCES LQGGSPSTTV TVTALEALLC PSATVTQVCS NPPCETHETG 1300
TTNTATTSNA GSAQRVCSNP PCETHETGTT HTATTATSNG GTGQPEGGQQ 1350
PPAGRPCETH QTTSTGTTMS VSVGALLPDA TSSHRTVESG LEVAAAPSVT 1400
PQAGTALLAP FPTQRVCSNP PCETHETGTT HTATTVTSNM SSNQDPPPAA 1450
SDQGEVESTQ GDSVNITSSS AITTTVSSTL TRAVTTVTQS TPVPGPSVPK 1500
ISSMTETAPR ALTTEVPIPA KITVTIANTE TSDMPFSAVD ILQPPEELQV 1550
SPGPRQQLPP RQLLQSASTA LMGESAEVLS ASQTPELPAA VDLSSTGEPS 1600
SGQESAGSAV VATVVVQPPP PTQSEVDQLS LPQELMAEAQ AGTTTLMVTG 1650
LTPEELAVTA AAEAAAQAAA TEEAQALAIQ AVLQAAQQAV MAGTGEPMDT 1700
SEAAATVTQA ELGHLSAEGQ EGQATTIPIV LTQQELAALV QQQQLQEAQA 1750
QQQHHHLPTE ALAPADSLND PAIESNCLNE LAGTVPSTVA LLPSTATESL 1800
APSNTFVAPQ PVVVASPAKL QAAATLTEVA NGIESLGVKP DLPPPPSKAP 1850
MKKENQWFDV GVIKGTNVMV THYFLPPDDA VPSDDDLGTV PDYNQLKKQE 1900
LQPGTAYKFR VAGINACGRG PFSEISAFKT CLPGFPGAPC AIKISKSPDG 1950
AHLTWEPPSV TSGKIIEYSV YLAIQSSQAG GELKSSTPAQ LAFMRVYCGP 2000
SPSCLVQSSS LSNAHIDYTT KPAIIFRIAA RNEKGYGPAT QVRWLQETSK 2050
DSSGTKPANK RPMSSPEMKS APKKSKADGQ 2080
Length:2,080
Mass (Da):213,476
Last modified:January 15, 2008 - v2
Checksum:iFD74143032C7E9D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52112 Genomic DNA. No translation available.
RefSeqiXP_006724878.1. XM_006724815.1.
UniGeneiHs.83634.

Genome annotation databases

EnsembliENST00000369984; ENSP00000359001; ENSG00000172534.
GeneIDi3054.
KEGGihsa:3054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52112 Genomic DNA. No translation available.
RefSeqi XP_006724878.1. XM_006724815.1.
UniGenei Hs.83634.

3D structure databases

ProteinModelPortali A6NEM2.
SMRi A6NEM2. Positions 360-400, 1856-2055.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi A6NEM2.
PRIDEi A6NEM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369984 ; ENSP00000359001 ; ENSG00000172534 .
GeneIDi 3054.
KEGGi hsa:3054.

Organism-specific databases

CTDi 3054.
HGNCi HGNC:4839. HCFC1.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000293192.
HOVERGENi HBG051888.
KOi K14966.
OMAi NGHNEMA.
OrthoDBi EOG790G05.
PhylomeDBi A6NEM2.

Miscellaneous databases

ChiTaRSi HCFC1. human.
NextBioi 35462505.

Gene expression databases

ArrayExpressi A6NEM2.
Bgeei A6NEM2.

Family and domain databases

Gene3Di 2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF01344. Kelch_1. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiA6NEM2_HUMAN
AccessioniPrimary (citable) accession number: A6NEM2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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