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Protein
Submitted name:

Host cell factor 1

Gene

HCFC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Host cell factor 1Imported
Gene namesi
Name:HCFC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4839. HCFC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172534.

PTM / Processingi

Proteomic databases

EPDiA6NEM2.
MaxQBiA6NEM2.
PaxDbiA6NEM2.
PeptideAtlasiA6NEM2.
PRIDEiA6NEM2.

Expressioni

Gene expression databases

BgeeiENSG00000172534.
ExpressionAtlasiA6NEM2. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiA6NEM2. 5 interactors.
STRINGi9606.ENSP00000309555.

Structurei

3D structure databases

ProteinModelPortaliA6NEM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini366 – 466Fibronectin type-IIIInterPro annotationAdd BLAST101
Domaini1842 – 1933Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini1935 – 2051Fibronectin type-IIIInterPro annotationAdd BLAST117

Keywords - Domaini

Kelch repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4152. Eukaryota.
ENOG410Y5AC. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000293192.
HOVERGENiHBG051888.
OMAiGQVCSNP.
OrthoDBiEOG091G00K7.
PhylomeDBiA6NEM2.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NEM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAVSPANL PAVLLQPRWK RVVGWSGPVP RPRHGHRAVA IKELIVVFGG
60 70 80 90 100
GNEGIVDELH VYNTATNQWF IPAVRGDIPP GCAAYGFVCD GTRLLVFGGM
110 120 130 140 150
VEYGKYSNDL YELQASRWEW KRLKAKTPKN GPPPCPRLGH SFSLVGNKCY
160 170 180 190 200
LFGGLANDSE DPKNNIPRYL NDLYILELRP GSGVVAWDIP ITYGVLPPPR
210 220 230 240 250
ESHTAVVYTE KDNKKSKLVI YGGMSGCRLG DLWTLDIDTL TWNKPSLSGV
260 270 280 290 300
APLPRSLHSA TTIGNKMYVF GGWVPLVMDD VKVATHEKEW KCTNTLACLN
310 320 330 340 350
LDTMAWETIL MDTLEDNIPR ARAGHCAVAI NTRLYIWSGR DGYRKAWNNQ
360 370 380 390 400
VCCKDLWYLE TEKPPPPARV QLVRANTNSL EVSWGAVATA DSYLLQLQKY
410 420 430 440 450
DIPATAATAT SPTPNPVPSV PANPPKSPAP AAAAPAVQPL TQVGITLLPQ
460 470 480 490 500
AAPAPPTTTT IQVLPTVPGS SISVPTAART QGVPAVLKVT GPQATTGTPL
510 520 530 540 550
VTMRPASQAG KAPVTVTSLP AGVRMVVPTQ SAQGTVIGSS PQMSGMAALA
560 570 580 590 600
AAAAATQKIP PSSAPTVLSV PAGTTIVKTM AVTPGTTTLP ATVKVASSPV
610 620 630 640 650
MVSNPATRML KTAAAQVGTS VSSATNTSTR PIITVHKSGT VTVAQQAQVV
660 670 680 690 700
TTVVGGVTKT ITLVKSPISV PGGSALISNL GKVMSVVQTK PVQTSAVTGQ
710 720 730 740 750
ASTGPVTQII QTKGPLPAGT ILKLVTSADG KPTTIITTTQ ASGAGTKPTI
760 770 780 790 800
LGISSVSPST TKPGTTTIIK TIPMSAIITQ AGATGVTSSP GIKSPITIIT
810 820 830 840 850
TKVMTSGTGA PAKIITAVPK IATGHGQQGV TQVVLKGAPG QPGTILRTVP
860 870 880 890 900
MGGVRLVTPV TVSAVKPAVT TLVVKGTTGV TTLGTVTGTV STSLAGAGGH
910 920 930 940 950
STSASLATPI TTLGTIATLS SQVINPTAIT VSAAQTTLTA AGGLTTPTIT
960 970 980 990 1000
MQPVSQPTQV TLITAPSGVE AQPVHDLPVS ILASPTTEQP TATVTIADSG
1010 1020 1030 1040 1050
QGDVQPGTVT LVCSNPPCET HETGTTNTAT TTVVANLGGH PQPTQVQFVC
1060 1070 1080 1090 1100
DRQEAAASLV TSTVGQQNGS VVRVCSNPPC ETHETGTTNT ATTATSNMAG
1110 1120 1130 1140 1150
QHGCSNPPCE THETGTTNTA TTAMSSVGAN HQRDARRACA AGTPAVIRIS
1160 1170 1180 1190 1200
VATGALEAAQ GSKSQCQTRQ TSATSTTMTV MATGAPCSAG PLLGPSMARE
1210 1220 1230 1240 1250
PGGRSPAFVQ LAPLSSKVRL SSPSIKDLPA GRHSHAVSTA AMTRSSVGAG
1260 1270 1280 1290 1300
EPRMAPVCES LQGGSPSTTV TVTALEALLC PSATVTQVCS NPPCETHETG
1310 1320 1330 1340 1350
TTNTATTSNA GSAQRVCSNP PCETHETGTT HTATTATSNG GTGQPEGGQQ
1360 1370 1380 1390 1400
PPAGRPCETH QTTSTGTTMS VSVGALLPDA TSSHRTVESG LEVAAAPSVT
1410 1420 1430 1440 1450
PQAGTALLAP FPTQRVCSNP PCETHETGTT HTATTVTSNM SSNQDPPPAA
1460 1470 1480 1490 1500
SDQGEVESTQ GDSVNITSSS AITTTVSSTL TRAVTTVTQS TPVPGPSVPK
1510 1520 1530 1540 1550
ISSMTETAPR ALTTEVPIPA KITVTIANTE TSDMPFSAVD ILQPPEELQV
1560 1570 1580 1590 1600
SPGPRQQLPP RQLLQSASTA LMGESAEVLS ASQTPELPAA VDLSSTGEPS
1610 1620 1630 1640 1650
SGQESAGSAV VATVVVQPPP PTQSEVDQLS LPQELMAEAQ AGTTTLMVTG
1660 1670 1680 1690 1700
LTPEELAVTA AAEAAAQAAA TEEAQALAIQ AVLQAAQQAV MAGTGEPMDT
1710 1720 1730 1740 1750
SEAAATVTQA ELGHLSAEGQ EGQATTIPIV LTQQELAALV QQQQLQEAQA
1760 1770 1780 1790 1800
QQQHHHLPTE ALAPADSLND PAIESNCLNE LAGTVPSTVA LLPSTATESL
1810 1820 1830 1840 1850
APSNTFVAPQ PVVVASPAKL QAAATLTEVA NGIESLGVKP DLPPPPSKAP
1860 1870 1880 1890 1900
MKKENQWFDV GVIKGTNVMV THYFLPPDDA VPSDDDLGTV PDYNQLKKQE
1910 1920 1930 1940 1950
LQPGTAYKFR VAGINACGRG PFSEISAFKT CLPGFPGAPC AIKISKSPDG
1960 1970 1980 1990 2000
AHLTWEPPSV TSGKIIEYSV YLAIQSSQAG GELKSSTPAQ LAFMRVYCGP
2010 2020 2030 2040 2050
SPSCLVQSSS LSNAHIDYTT KPAIIFRIAA RNEKGYGPAT QVRWLQETSK
2060 2070 2080
DSSGTKPANK RPMSSPEMKS APKKSKADGQ
Length:2,080
Mass (Da):213,476
Last modified:January 15, 2008 - v2
Checksum:iFD74143032C7E9D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52112 Genomic DNA. No translation available.
RefSeqiXP_006724878.1. XM_006724815.2.
UniGeneiHs.83634.

Genome annotation databases

EnsembliENST00000369984; ENSP00000359001; ENSG00000172534.
GeneIDi3054.
UCSCiuc065cab.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52112 Genomic DNA. No translation available.
RefSeqiXP_006724878.1. XM_006724815.2.
UniGeneiHs.83634.

3D structure databases

ProteinModelPortaliA6NEM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NEM2. 5 interactors.
STRINGi9606.ENSP00000309555.

Proteomic databases

EPDiA6NEM2.
MaxQBiA6NEM2.
PaxDbiA6NEM2.
PeptideAtlasiA6NEM2.
PRIDEiA6NEM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369984; ENSP00000359001; ENSG00000172534.
GeneIDi3054.
UCSCiuc065cab.1. human.

Organism-specific databases

CTDi3054.
HGNCiHGNC:4839. HCFC1.
OpenTargetsiENSG00000172534.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4152. Eukaryota.
ENOG410Y5AC. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000293192.
HOVERGENiHBG051888.
OMAiGQVCSNP.
OrthoDBiEOG091G00K7.
PhylomeDBiA6NEM2.

Miscellaneous databases

ChiTaRSiHCFC1. human.
GenomeRNAii3054.

Gene expression databases

BgeeiENSG00000172534.
ExpressionAtlasiA6NEM2. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6NEM2_HUMAN
AccessioniPrimary (citable) accession number: A6NEM2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.